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    TNFAIP8L3 TNF alpha induced protein 8 like 3 [ Homo sapiens (human) ]

    Gene ID: 388121, updated on 17-Jun-2024

    Summary

    Official Symbol
    TNFAIP8L3provided by HGNC
    Official Full Name
    TNF alpha induced protein 8 like 3provided by HGNC
    Primary source
    HGNC:HGNC:20620
    See related
    Ensembl:ENSG00000183578 MIM:616438; AllianceGenome:HGNC:20620
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TIPE3
    Summary
    Predicted to enable phosphatidylinositol binding activity and phosphatidylinositol transfer activity. Predicted to be involved in several processes, including inositol lipid-mediated signaling; positive regulation of intracellular signal transduction; and positive regulation of phosphatidylinositol 3-kinase activity. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in endometrium (RPKM 16.6), esophagus (RPKM 6.5) and 15 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See TNFAIP8L3 in Genome Data Viewer
    Location:
    15q21.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (51056601..51105276, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (48864239..48912949, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (51348798..51397473, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903490 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9398 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9399 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:51174366-51174535 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9400 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr15:51200473-51201214 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:51201215-51201956 Neighboring gene adaptor related protein complex 4 subunit epsilon 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:51258822-51259047 Neighboring gene DDB1 and CUL4 associated factor 13 pseudogene 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:51296421-51296666 Neighboring gene MPRA-validated peak2335 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr15:51336200-51336731 Neighboring gene MIR4713 host gene Neighboring gene Sharpr-MPRA regulatory region 8572 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:51368968-51369524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9403 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:51386125-51386855 Neighboring gene uncharacterized LOC124903491 Neighboring gene uncharacterized LOC124903492 Neighboring gene Sharpr-MPRA regulatory region 3311 Neighboring gene Sharpr-MPRA regulatory regions 2939 and 12041 Neighboring gene cytochrome P450 family 19 subfamily A member 1 Neighboring gene CYP19A1 promoter II/1.3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:51559063-51559696 Neighboring gene microRNA 4713 Neighboring gene CYP19A1 promoter I.7 Neighboring gene uncharacterized LOC124903493

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ41287

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables phosphatidylinositol binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables phosphatidylinositol transfer activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables phosphatidylinositol transfer activity TAS
    Traceable Author Statement
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intermembrane lipid transfer IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phospholipid metabolic process TAS
    Traceable Author Statement
    more info
     
    involved_in phospholipid transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    tumor necrosis factor alpha-induced protein 8-like protein 3
    Names
    TNF alpha-induced protein 8-like protein 3
    TNFAIP8-like protein 3
    tumor necrosis factor, alpha induced protein 8 like 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311175.2NP_001298104.1  tumor necrosis factor alpha-induced protein 8-like protein 3 isoform 2

      See identical proteins and their annotated locations for NP_001298104.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC073964, AK123281, CA447540, HY052681
      Consensus CDS
      CCDS81881.1
      UniProtKB/TrEMBL
      A0A1B0GTK8
      Related
      ENSP00000489743.1, ENST00000637513.2
      Conserved Domains (1) summary
      pfam05527
      Location:23201
      DUF758; Domain of unknown function (DUF758)
    2. NM_207381.4NP_997264.2  tumor necrosis factor alpha-induced protein 8-like protein 3 isoform 1

      See identical proteins and their annotated locations for NP_997264.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AY517501, CA447540
      Consensus CDS
      CCDS32241.1
      UniProtKB/Swiss-Prot
      Q5GJ75, Q6ZWD1
      Related
      ENSP00000328016.5, ENST00000327536.5
      Conserved Domains (1) summary
      pfam05527
      Location:111289
      DUF758; Domain of unknown function (DUF758)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      51056601..51105276 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      48864239..48912949 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)