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    TNFAIP8L3 TNF alpha induced protein 8 like 3 [ Homo sapiens (human) ]

    Gene ID: 388121, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TNFAIP8L3provided by HGNC
    Official Full Name
    TNF alpha induced protein 8 like 3provided by HGNC
    Primary source
    HGNC:HGNC:20620
    See related
    Ensembl:ENSG00000183578 MIM:616438; AllianceGenome:HGNC:20620
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TIPE3
    Summary
    Predicted to enable phosphatidylinositol binding activity and phosphatidylinositol transfer activity. Predicted to be involved in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process; phospholipid transport; and positive regulation of ERK1 and ERK2 cascade. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in endometrium (RPKM 16.6), esophagus (RPKM 6.5) and 15 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TNFAIP8L3 in Genome Data Viewer
    Location:
    15q21.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (51056601..51105276, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (48864239..48912949, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (51348798..51397473, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903490 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9398 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9399 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:51174366-51174535 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9400 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr15:51200473-51201214 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:51201215-51201956 Neighboring gene adaptor related protein complex 4 subunit epsilon 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:51258822-51259047 Neighboring gene DDB1 and CUL4 associated factor 13 pseudogene 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:51296421-51296666 Neighboring gene MPRA-validated peak2335 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr15:51336200-51336731 Neighboring gene MIR4713 host gene Neighboring gene Sharpr-MPRA regulatory region 8572 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:51368968-51369524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9403 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:51386125-51386855 Neighboring gene uncharacterized LOC124903491 Neighboring gene uncharacterized LOC124903492 Neighboring gene Sharpr-MPRA regulatory region 3311 Neighboring gene Sharpr-MPRA regulatory regions 2939 and 12041 Neighboring gene cytochrome P450 family 19 subfamily A member 1 Neighboring gene CYP19A1 promoter II/1.3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:51559063-51559696 Neighboring gene microRNA 4713 Neighboring gene CYP19A1 promoter I.7 Neighboring gene uncharacterized LOC124903493

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Comprehensive analysis of the prognostic and immunological roles of TIPE3 in Colon Cancer. Xia HB, et al. Asian J Surg, 2024 Mar. PMID 38071098
    2. TIPE3 protein promotes breast cancer metastasis through activating AKT and NF-κB signaling pathways. Lian K, et al. Oncotarget, 2017 Jul 25. PMID 28388580, Free PMC Article
    3. TIPE3 differentially modulates proliferation and migration of human non-small-cell lung cancer cells via distinct subcellular location. Wang G, et al. BMC Cancer, 2018 Mar 6. PMID 29510688, Free PMC Article
    4. TIPE3 hypermethylation correlates with worse prognosis and promotes tumor progression in nasopharyngeal carcinoma. Ren XY, et al. J Exp Clin Cancer Res, 2018 Sep 14. PMID 30217224, Free PMC Article
    5. TIPE3 is a regulator of cell apoptosis in glioblastoma. Yuan F, et al. Cancer Lett, 2019 Apr 1. PMID 30639532

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Down-regulated expression of TIPE3 inhibits malignant progression of non-small cell lung cancer via Wnt signaling.
      Title: Down-regulated expression of TIPE3 inhibits malignant progression of non-small cell lung cancer via Wnt signaling.
    2. Comprehensive analysis of the prognostic and immunological roles of TIPE3 in Colon Cancer.
      Title: Comprehensive analysis of the prognostic and immunological roles of TIPE3 in Colon Cancer.
    3. TIPE3 represses head and neck squamous cell carcinoma progression via triggering PGAM5 mediated mitochondria dysfunction.
      Title: TIPE3 represses head and neck squamous cell carcinoma progression via triggering PGAM5 mediated mitochondria dysfunction.
    4. TIPE3 protects mice from lipopolysaccharide-induced acute lung injury.
      Title: TIPE3 protects mice from lipopolysaccharide-induced acute lung injury.
    5. Tumor necrosis factor-alpha-inducible protein 8-like protein 3 (TIPE3): a novel prognostic factor in colorectal cancer.
      Title: Tumor necrosis factor-α-inducible protein 8-like protein 3 (TIPE3): a novel prognostic factor in colorectal cancer.
    6. Loss of TIPE3 reduced the proliferation, survival and migration of lung cancer cells through inactivation of Akt/mTOR, NF-kappaB, and STAT-3 signaling cascades.
      Title: Loss of TIPE3 reduced the proliferation, survival and migration of lung cancer cells through inactivation of Akt/mTOR, NF-κB, and STAT-3 signaling cascades.
    7. Effects of the long and short isoforms of TIPE3 on the growth and metastasis of gastric cancer.
      Title: Effects of the long and short isoforms of TIPE3 on the growth and metastasis of gastric cancer.
    8. TNFAIP8L3 is highly expressed in human cancer cells and promotes carcinogenesis. Silence of TNFAIP8L3 diminished Gastric Cancer cells migration mediated by miR-9-5p.
      Title: miR-9-5p Suppresses Malignant Biological Behaviors of Human Gastric Cancer Cells by Negative Regulation of TNFAIP8L3.
    9. TIPE3 inhibits p38 phosphorylation and blocks p38 nuclear translocation to inhibit glioblastoma cell apoptosis.
      Title: TIPE3 is a regulator of cell apoptosis in glioblastoma.
    10. In addition to replicating a previously identified genome-wide significant locus for corneal astigmatism near the PDGFRA gene, gene-based analysis identified three novel candidate genes, CLDN7, ACP2, and TNFAIP8L3, that warrant further investigation to understand their role in the pathogenesis of corneal astigmatism. (Meta-analysis)
      Title: A genome-wide association study of corneal astigmatism: The CREAM Consortium.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Common genetic variation and performance on standardized cognitive tests.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ41287

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables phosphatidylinositol binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatidylinositol transfer activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatidylinositol transfer activity TAS
    Traceable Author Statement
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in intermembrane lipid transfer IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid metabolic process TAS
    Traceable Author Statement
    more info
    		  
    involved_in phospholipid transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    tumor necrosis factor alpha-induced protein 8-like protein 3
    Names
    TNF alpha-induced protein 8-like protein 3
    TNFAIP8-like protein 3
    tumor necrosis factor, alpha induced protein 8 like 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311175.2 → NP_001298104.1  tumor necrosis factor alpha-induced protein 8-like protein 3 isoform 2

      See identical proteins and their annotated locations for NP_001298104.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC073964, AK123281, CA447540, HY052681
      Consensus CDS
      CCDS81881.1
      UniProtKB/TrEMBL
      A0A1B0GTK8
      Related
      ENSP00000489743.1, ENST00000637513.2
      Conserved Domains (1) summary
      pfam05527
      Location:23 → 201
      DUF758; Domain of unknown function (DUF758)

    2. NM_207381.4 → NP_997264.2  tumor necrosis factor alpha-induced protein 8-like protein 3 isoform 1

      See identical proteins and their annotated locations for NP_997264.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AY517501, CA447540
      Consensus CDS
      CCDS32241.1
      UniProtKB/Swiss-Prot
      Q5GJ75, Q6ZWD1
      Related
      ENSP00000328016.5, ENST00000327536.5
      Conserved Domains (1) summary
      pfam05527
      Location:111 → 289
      DUF758; Domain of unknown function (DUF758)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      51056601..51105276 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      48864239..48912949 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5GJ75.1 GenPept UniProtKB/Swiss-Prot:Q5GJ75

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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