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    KRT13 keratin 13 [ Homo sapiens (human) ]

    Gene ID: 3860, updated on 17-Jun-2024

    Summary

    Official Symbol
    KRT13provided by HGNC
    Official Full Name
    keratin 13provided by HGNC
    Primary source
    HGNC:HGNC:6415
    See related
    Ensembl:ENSG00000171401 MIM:148065; AllianceGenome:HGNC:6415
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    K13; CK13; WSN2
    Summary
    The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus. The type I cytokeratins are clustered in a region of chromosome 17q21.2. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been described. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward esophagus (RPKM 15373.8) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See KRT13 in Genome Data Viewer
    Location:
    17q21.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (41500981..41505612, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (42356534..42361165, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (39657233..39661864, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene keratin 35 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:39642150-39643103 Neighboring gene keratin 36 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:39672893-39673777 Neighboring gene keratin 15 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:39675482-39676481 Neighboring gene microRNA 6510 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:39677595-39678794 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:39683757-39684456 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:39684457-39685154 Neighboring gene keratin 19

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC3781, MGC161462

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in epithelial cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of translation in response to stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in intermediate filament cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in keratin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in keratin filament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus HDA PubMed 

    General protein information

    Preferred Names
    keratin, type I cytoskeletal 13
    Names
    CK-13
    cytokeratin 13
    keratin 13, type I

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008406.2 RefSeqGene

      Range
      5000..9631
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002274.4NP_002265.3  keratin, type I cytoskeletal 13 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) utilizes an alternate splice site in the 3' coding region, which results in a frameshift and early stop codon, compared to transcript variant 1. The encoded isoform (b) is shorter, compared to isoform a.
      Source sequence(s)
      AC019349
      Consensus CDS
      CCDS11397.1
      UniProtKB/TrEMBL
      K7ERE3
      Related
      ENSP00000336604.3, ENST00000336861.7
      Conserved Domains (1) summary
      pfam00038
      Location:103415
      Filament; Intermediate filament protein
    2. NM_153490.3NP_705694.3  keratin, type I cytoskeletal 13 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC019349
      Consensus CDS
      CCDS11396.1
      UniProtKB/Swiss-Prot
      P13646, Q53G54, Q6AZK5, Q8N240
      UniProtKB/TrEMBL
      A8K2H9
      Related
      ENSP00000246635.3, ENST00000246635.8
      Conserved Domains (1) summary
      pfam00038
      Location:103415
      Filament; Intermediate filament protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      41500981..41505612 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      42356534..42361165 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)