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    Rrm2b ribonucleotide reductase M2 B (TP53 inducible) [ Mus musculus (house mouse) ]

    Gene ID: 382985, updated on 23-May-2018

    Summary

    Official Symbol
    Rrm2bprovided by MGI
    Official Full Name
    ribonucleotide reductase M2 B (TP53 inducible)provided by MGI
    Primary source
    MGI:MGI:2155865
    See related
    Ensembl:ENSMUSG00000022292 Vega:OTTMUSG00000032790
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p53R2
    Expression
    Ubiquitous expression in bladder adult (RPKM 3.1), frontal lobe adult (RPKM 2.6) and 24 other tissues See more
    Orthologs

    Genomic context

    See Rrm2b in Genome Data Viewer
    Location:
    15; 15 B3.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (37923952..37961110, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (37853707..37890810, complement)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein S19, pseudogene 5 Neighboring gene predicted gene, 35019 Neighboring gene 60S ribosomal protein L23a pseudogene Neighboring gene ubiquitin protein ligase E3 component n-recognin 5 Neighboring gene predicted gene, 35081

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    deoxyribonucleoside triphosphate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    deoxyribonucleotide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    deoxyribonucleotide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrial DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    renal system process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion IC
    Inferred by Curator
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ribonucleoside-diphosphate reductase subunit M2 B
    Names
    TP53-inducible ribonucleotide reductase M2 B
    p53-inducible ribonucleotide reductase small subunit 2-like protein
    NP_955770.1
    XP_006520164.1
    XP_006520165.1
    XP_011243663.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357022.1NP_001343951.1  ribonucleoside-diphosphate reductase subunit M2 B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC122291
      Conserved Domains (1) summary
      cl00264
      Location:18337
      Ferritin_like; Ferritin-like superfamily of diiron-containing four-helix-bundle proteins
    2. NM_001357023.1NP_001343952.1  ribonucleoside-diphosphate reductase subunit M2 B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122291
      Conserved Domains (1) summary
      cl00264
      Location:1297
      Ferritin_like; Ferritin-like superfamily of diiron-containing four-helix-bundle proteins
    3. NM_199476.1NP_955770.1  ribonucleoside-diphosphate reductase subunit M2 B isoform 1

      See identical proteins and their annotated locations for NP_955770.1

      Status: VALIDATED

      Source sequence(s)
      BC058103
      Consensus CDS
      CCDS27437.1
      UniProtKB/Swiss-Prot
      Q6PEE3
      Related
      ENSMUSP00000022901.9, OTTMUSP00000043707, ENSMUST00000022901.15, OTTMUST00000081651
      Conserved Domains (1) summary
      cl00264
      Location:32351
      Ferritin_like; Ferritin-like superfamily of diiron-containing four-helix-bundle proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      37923952..37961110 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520102.3XP_006520165.1  ribonucleoside-diphosphate reductase subunit M2 B isoform X2

      Conserved Domains (1) summary
      cl00264
      Location:1297
      Ferritin_like; Ferritin-like superfamily of diiron-containing four-helix-bundle proteins
    2. XM_006520101.2XP_006520164.1  ribonucleoside-diphosphate reductase subunit M2 B isoform X1

      Conserved Domains (1) summary
      cl00264
      Location:18337
      Ferritin_like; Ferritin-like superfamily of diiron-containing four-helix-bundle proteins
    3. XM_011245361.2XP_011243663.1  ribonucleoside-diphosphate reductase subunit M2 B isoform X3

      Conserved Domains (1) summary
      cl00264
      Location:32194
      Ferritin_like; Ferritin-like superfamily of diiron-containing four-helix-bundle proteins
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