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    RBPMS2 RNA binding protein, mRNA processing factor 2 [ Homo sapiens (human) ]

    Gene ID: 348093, updated on 19-Sep-2024

    Summary

    Official Symbol
    RBPMS2provided by HGNC
    Official Full Name
    RNA binding protein, mRNA processing factor 2provided by HGNC
    Primary source
    HGNC:HGNC:19098
    See related
    Ensembl:ENSG00000166831 MIM:619034; AllianceGenome:HGNC:19098
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene is a member of the RNA recognition motif (RRM)-containing protein family and is involved in the development and dedifferentiation of digestive smooth muscle cells. The encoded protein functions as a homodimer and indirectly inhibits the bone morphogenetic protein pathway. [provided by RefSeq, Aug 2016]
    Expression
    Biased expression in heart (RPKM 68.7), urinary bladder (RPKM 14.2) and 8 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See RBPMS2 in Genome Data Viewer
    Location:
    15q22.31
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (64739891..64775589, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (62549148..62584861, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (65032090..65067788, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:64991763-64992599 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:64992600-64993437 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6536 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6537 Neighboring gene ornithine decarboxylase antizyme 2 Neighboring gene uncharacterized LOC124903507 Neighboring gene MPRA-validated peak2370 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65010266-65010766 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:65024140-65024787 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:65024788-65025436 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:65028357-65029336 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65034779-65035280 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:65042170-65043145 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9576 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9577 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:65055942-65056827 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65063339-65063840 Neighboring gene microRNA 1272 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:65067649-65068495 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:65068496-65069341 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:65091461-65092363 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:65097880-65098388 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:65098896-65099403 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:65100927-65101434 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:65102957-65103464 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:65103465-65103970 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65111682-65112182 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65114079-65114580 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:65116122-65116789 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9578 Neighboring gene PIF1 5'-to-3' DNA helicase Neighboring gene uncharacterized LOC124903508 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9579

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in embryonic digestive tract morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of BMP signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of smooth muscle cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of smooth muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of smooth muscle cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of smooth muscle cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of alternative mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    RNA-binding protein with multiple splicing 2
    Names
    RNA binding protein with multiple splicing 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_194272.3NP_919248.1  RNA-binding protein with multiple splicing 2

      See identical proteins and their annotated locations for NP_919248.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the protein-coding transcript.
      Source sequence(s)
      AC091582, AI274305, AK127873
      Consensus CDS
      CCDS32271.1
      UniProtKB/Swiss-Prot
      A2RRG0, Q6ZRY4
      Related
      ENSP00000300069.4, ENST00000300069.5
      Conserved Domains (1) summary
      cd12683
      Location:30105
      RRM_RBPMS2; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing 2 (RBP-MS2)

    RNA

    1. NR_138350.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC091582, AI274305, AK127873, DA564899
    2. NR_138363.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' end compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AI274305, AK127873, DA565836
    3. NR_138364.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' end compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AC100830, AI274305, AK124123
      Related
      ENST00000560606.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      64739891..64775589 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047432446.1XP_047288402.1  RNA-binding protein with multiple splicing 2 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      62549148..62584861 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054377837.1XP_054233812.1  RNA-binding protein with multiple splicing 2 isoform X1