U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    HTR1E 5-hydroxytryptamine receptor 1E [ Homo sapiens (human) ]

    Gene ID: 3354, updated on 17-Jun-2024

    Summary

    Official Symbol
    HTR1Eprovided by HGNC
    Official Full Name
    5-hydroxytryptamine receptor 1Eprovided by HGNC
    Primary source
    HGNC:HGNC:5291
    See related
    Ensembl:ENSG00000168830 MIM:182132; AllianceGenome:HGNC:5291
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    5-HT1E
    Summary
    Enables G protein-coupled serotonin receptor activity and serotonin binding activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in ovary (RPKM 1.3), endometrium (RPKM 0.7) and 4 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See HTR1E in Genome Data Viewer
    Location:
    6q14.3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (86937528..87016679)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (88146245..88225391)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (87647246..87726397)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene SUZ RNA binding domain containing 1 pseudogene Neighboring gene RNA, 7SL, cytoplasmic 643, pseudogene Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:87291002-87292201 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:87307995-87308547 Neighboring gene MPRA-validated peak5941 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:87380117-87380640 Neighboring gene Sharpr-MPRA regulatory region 4618 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:87433363-87434562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:87440887-87441388 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:87441389-87441888 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:87497596-87498795 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr6:87607342-87607842 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr6:87607843-87608343 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:87647030-87647585 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:87647586-87648140 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:87679014-87680213 Neighboring gene ribosomal protein L7 pseudogene 29 Neighboring gene methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase pseudogene 2 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr6:87748156-87748680 Neighboring gene small integral membrane protein 30-like Neighboring gene RN7SK pseudogene 209

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables G protein-coupled serotonin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled serotonin receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables G protein-coupled serotonin receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables neurotransmitter receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables serotonin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    5-hydroxytryptamine receptor 1E
    Names
    5-HT-1E
    5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
    S31
    serotonin receptor 1E

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000865.3NP_000856.1  5-hydroxytryptamine receptor 1E

      See identical proteins and their annotated locations for NP_000856.1

      Status: VALIDATED

      Source sequence(s)
      AL157777, AL521170, BC069751, M91467
      Consensus CDS
      CCDS5006.1
      UniProtKB/Swiss-Prot
      E1P503, P28566, Q9P1Y1
      Related
      ENSP00000307766.4, ENST00000305344.7
      Conserved Domains (1) summary
      cd15335
      Location:23355
      7tmA_5-HT1E; serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      86937528..87016679
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011535789.3XP_011534091.1  5-hydroxytryptamine receptor 1E isoform X1

      See identical proteins and their annotated locations for XP_011534091.1

      UniProtKB/Swiss-Prot
      E1P503, P28566, Q9P1Y1
      Conserved Domains (1) summary
      cd15335
      Location:23355
      7tmA_5-HT1E; serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      88146245..88225391
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054355315.1XP_054211290.1  5-hydroxytryptamine receptor 1E isoform X1

      UniProtKB/Swiss-Prot
      E1P503, P28566, Q9P1Y1