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    Elba2 Early boundary activity 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33442, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Elba2provided by FlyBase
    Official Full Name
    Early boundary activity 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0031435
    Locus tag
    Dmel_CG9883
    See related
    AllianceGenome:FB:FBgn0031435
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9883; Dmel\CG9883; Elba
    Summary
    Enables chromatin binding activity. Contributes to chromatin insulator sequence binding activity and sequence-specific DNA binding activity. Involved in heterochromatin boundary formation and negative regulation of transcription, DNA-templated. Located in nucleus and polytene chromosome band. Part of chromatin silencing complex. Is expressed in several structures, including anlage in statu nascendi; ectoderm; ectoderm anlage; extended germ band embryo; and spermatozoon. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Elba2 in Genome Data Viewer
    Location:
    23A1-23A1; 2-7 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2577687..2579179)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2577687..2579179)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Radiation insensitive 1 Neighboring gene SWIM domain containing Srs2 interacting protein 1 Neighboring gene insensitive Neighboring gene NADH dehydrogenase (ubiquinone) B17.2 subunit Neighboring gene Actin-related protein 2/3 complex, subunit 5 Neighboring gene Dynamin related protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The BEN Domain Protein Insensitive Binds to the Fab-7 Chromatin Boundary To Establish Proper Segmental Identity in Drosophila. Fedotova A, et al. Genetics, 2018 Oct. PMID 30082280, Free PMC Article
    2. BEN domain protein Elba2 can functionally substitute for linker histone H1 in Drosophila in vivo. Xu N, et al. Sci Rep, 2016 Sep 30. PMID 27687115, Free PMC Article
    3. A stage-specific factor confers Fab-7 boundary activity during early embryogenesis in Drosophila. Aoki T, et al. Mol Cell Biol, 2008 Feb. PMID 18039839, Free PMC Article
    4. BEN-solo factors partition active chromatin to ensure proper gene activation in Drosophila. Ueberschär M, et al. Nat Commun, 2019 Dec 13. PMID 31836703, Free PMC Article
    5. Different Evolutionary Strategies To Conserve Chromatin Boundary Function in the Bithorax Complex. Cleard F, et al. Genetics, 2017 Feb. PMID 28007886, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Elba, a novel developmentally regulated chromatin boundary factor is a hetero-tripartite DNA binding complex.
      Title: Elba, a novel developmentally regulated chromatin boundary factor is a hetero-tripartite DNA binding complex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to chromatin insulator sequence binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heterochromatin boundary formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of chromatin silencing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome band IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    early boundary activity 2
    Names
    CG9883-PA
    Elba2-PA
    early boundary factor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      2577687..2579179
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134847.3 → NP_608691.1  early boundary activity 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608691.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VQD6
      Related
      FBpp0077377
      Conserved Domains (1) summary
      pfam10523
      Location:289 → 358
      BEN; BEN domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VQD6.1 Q9VQD6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
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