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    PPM1J protein phosphatase, Mg2+/Mn2+ dependent 1J [ Homo sapiens (human) ]

    Gene ID: 333926, updated on 5-Mar-2024

    Summary

    Official Symbol
    PPM1Jprovided by HGNC
    Official Full Name
    protein phosphatase, Mg2+/Mn2+ dependent 1Jprovided by HGNC
    Primary source
    HGNC:HGNC:20785
    See related
    Ensembl:ENSG00000155367 MIM:609957; AllianceGenome:HGNC:20785
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PP2CZ; PPP2CZ; PP2Czeta; PP2C-zeta
    Summary
    This gene encodes the serine/threonine protein phosphatase. The mouse homolog of this gene apparently belongs to the protein phosphatase 2C family of genes. The exact function of this gene is not yet known. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in testis (RPKM 22.7), skin (RPKM 8.1) and 5 other tissues See more
    Orthologs
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    Genomic context

    See PPM1J in Genome Data Viewer
    Location:
    1p13.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (112709998..112715332, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (112722547..112727883, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (113252620..113257954, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1202 Neighboring gene Mov10 RNA helicase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:113234976-113235476 Neighboring gene Sharpr-MPRA regulatory region 4682 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:113242906-113243833 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:113246858-113247412 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1517 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1203 Neighboring gene ras homolog family member C Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1518 Neighboring gene Sharpr-MPRA regulatory region 11832 Neighboring gene PPM1J divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1205 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:113266466-113266670 Neighboring gene TAFA chemokine like family member 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: RHOC

    Clone Names

    • FLJ35951, MGC19531, MGC90149, DKFZp434P1514

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in protein dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    protein phosphatase 1J
    Names
    protein phosphatase 1J (PP2C domain containing)
    protein phosphatase 2C zeta
    NP_005158.5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005167.7NP_005158.5  protein phosphatase 1J

      See identical proteins and their annotated locations for NP_005158.5

      Status: REVIEWED

      Source sequence(s)
      AL603832
      Consensus CDS
      CCDS855.2
      UniProtKB/Swiss-Prot
      B3KSB7, Q5JR12, Q6DKJ7, Q96EZ7, Q9UF84
      Related
      ENSP00000308926.6, ENST00000309276.11
      Conserved Domains (1) summary
      cd00143
      Location:106498
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      112709998..112715332 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      112722547..112727883 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)