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    CTAG2 cancer/testis antigen 2 [ Homo sapiens (human) ]

    Gene ID: 30848, updated on 17-Jun-2024

    Summary

    Official Symbol
    CTAG2provided by HGNC
    Official Full Name
    cancer/testis antigen 2provided by HGNC
    Primary source
    HGNC:HGNC:2492
    See related
    Ensembl:ENSG00000126890 MIM:300396; AllianceGenome:HGNC:2492
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT2; ESO2; CAMEL; CT6.2; CT6.2a; CT6.2b; LAGE-1; LAGE2B
    Summary
    This gene encodes an autoimmunogenic tumor antigen that belongs to the ESO/LAGE family of cancer-testis antigens. This protein is expressed in a wide array of cancers including melanoma, breast cancer, bladder cancer and prostate cancer. This protein is also expressed in normal testis tissue. An alternative open reading frame product of this gene has been described in PMID:10399963. This alternate protein, termed CAMEL, is a tumor antigen that is recognized by melanoma-specific cytotoxic T-lymphocytes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
    Expression
    Biased expression in testis (RPKM 2.5), placenta (RPKM 1.4) and 2 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See CTAG2 in Genome Data Viewer
    Location:
    Xq28
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (154651977..154653579, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (152888418..152890020, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (153880251..153881853, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 223 member B Neighboring gene IKBKGP1 upstream recombination region Neighboring gene inhibitor of nuclear factor kappa B kinase subunit gamma pseudogene 1 Neighboring gene IKBKGP1 recombination region Neighboring gene uncharacterized LOC105373387 Neighboring gene olfactory receptor family 3 subfamily B member 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association analysis of red blood cell traits in African Americans: the COGENT Network.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC3803, MGC138724

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in tRNA threonylcarbamoyladenosine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    cancer/testis antigen 2
    Names
    CTL-recognized antigen on melanoma
    LAGE-1a protein
    autoimmunogenic cancer/testis antigen NY-ESO-2
    cancer/testis antigen 6.2
    cancer/testis antigen family 6, member 2a
    cancer/testis antigen family 6, member 2b
    l antigen family member 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021275.2 RefSeqGene

      Range
      5001..6603
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_020994.5NP_066274.2  cancer/testis antigen 2 isoform LAGE-1b

      See identical proteins and their annotated locations for NP_066274.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an additional segment in the 3' coding region which results in a frameshift, compared to variant 1. The encoded isoform (LAGE-1b, also known as LAGE-1L) is longer and has a distinct C-terminus, compared to isoform LAGE-1a.
      Source sequence(s)
      AJ223040, BC002833
      Consensus CDS
      CCDS14759.1
      UniProtKB/Swiss-Prot
      O75637, O75638, Q0VIL6, Q14CD6, Q2Z1N4, Q9BU80, Q9UJ89, Q9Y479
      Related
      ENSP00000247306.4, ENST00000247306.4
      Conserved Domains (1) summary
      pfam09341
      Location:90141
      Pcc1; Transcription factor Pcc1
    2. NM_172377.5NP_758965.2  cancer/testis antigen 2 isoform LAGE-1a

      See identical proteins and their annotated locations for NP_758965.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform LAGE-1a (also known as LAGE-1S).
      Source sequence(s)
      AJ223040, BC113998
      Consensus CDS
      CCDS35455.1
      UniProtKB/Swiss-Prot
      O75638
      Related
      ENSP00000358598.3, ENST00000369585.4
      Conserved Domains (1) summary
      pfam09341
      Location:90162
      Pcc1; Transcription factor Pcc1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      154651977..154653579 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      152888418..152890020 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)