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    GSTA1 glutathione S-transferase alpha 1 [ Homo sapiens (human) ]

    Gene ID: 2938, updated on 10-Jun-2024

    Summary

    Official Symbol
    GSTA1provided by HGNC
    Official Full Name
    glutathione S-transferase alpha 1provided by HGNC
    Primary source
    HGNC:HGNC:4626
    See related
    Ensembl:ENSG00000243955 MIM:138359; AllianceGenome:HGNC:4626
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GST2; GTH1; GSTA1-1; GST-epsilon
    Summary
    This gene encodes a member of a family of enzymes that function to add glutathione to target electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. This action is an important step in detoxification of these compounds. This subfamily of enzymes has a particular role in protecting cells from reactive oxygen species and the products of peroxidation. Polymorphisms in this gene influence the ability of individuals to metabolize different drugs. This gene is located in a cluster of similar genes and pseudogenes on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
    Expression
    Biased expression in liver (RPKM 342.4), kidney (RPKM 288.3) and 6 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See GSTA1 in Genome Data Viewer
    Location:
    6p12.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (52791371..52803816, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (52630148..52642586, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (52656169..52668614, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase alpha 2 Neighboring gene glutathione S-transferase alpha 12, pseudogene Neighboring gene glutathione S-transferase alpha 6, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24690 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_92146 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_92147 Neighboring gene glutathione S-transferase alpha 5 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_92148 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_92149

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC131939

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables fatty acid binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables glutathione peroxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glutathione transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables glutathione transferase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables steroid delta-isomerase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 

    General protein information

    Preferred Names
    glutathione S-transferase A1
    Names
    13-hydroperoxyoctadecadienoate peroxidase
    GST HA subunit 1
    GST class-alpha member 1
    S-(hydroxyalkyl)glutathione lyase A1
    androst-5-ene-3,17-dione isomerase
    glutathione S-alkyltransferase A1
    glutathione S-aryltransferase A1
    glutathione S-transferase 2
    glutathione S-transferase Ha subunit 1
    testicular tissue protein Li 80
    NP_001305988.1
    NP_665683.1
    XP_005249091.1
    XP_054211231.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001319059.2NP_001305988.1  glutathione S-transferase A1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AL590363
      Conserved Domains (1) summary
      cd03208
      Location:1127
      GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
    2. NM_145740.5NP_665683.1  glutathione S-transferase A1 isoform 1

      See identical proteins and their annotated locations for NP_665683.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encode the longer isoform (1).
      Source sequence(s)
      AL590363, BC053578, BM973137, DC339498
      Consensus CDS
      CCDS4945.1
      UniProtKB/Swiss-Prot
      P08263, Q14750, Q5GHF8, Q5SZC1
      UniProtKB/TrEMBL
      A0A140VJK4, A8K987, B2R920
      Related
      ENSP00000335620.5, ENST00000334575.6
      Conserved Domains (2) summary
      cd03208
      Location:86220
      GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
      cd03077
      Location:482
      GST_N_Alpha; GST_N family, Class Alpha subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      52791371..52803816 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005249034.5XP_005249091.1  glutathione S-transferase A1 isoform X1

      See identical proteins and their annotated locations for XP_005249091.1

      UniProtKB/TrEMBL
      A8K987, B2R920, B7Z1F9
      Conserved Domains (2) summary
      cd03077
      Location:482
      GST_N_Alpha; GST_N family, Class Alpha subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
      cl02776
      Location:86182
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      52630148..52642586 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054355256.1XP_054211231.1  glutathione S-transferase A1 isoform X1

      UniProtKB/TrEMBL
      A8K987, B2R920, B7Z1F9