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    RANGRF RAN guanine nucleotide release factor [ Homo sapiens (human) ]

    Gene ID: 29098, updated on 17-Jun-2024

    Summary

    Official Symbol
    RANGRFprovided by HGNC
    Official Full Name
    RAN guanine nucleotide release factorprovided by HGNC
    Primary source
    HGNC:HGNC:17679
    See related
    Ensembl:ENSG00000108961 MIM:607954; AllianceGenome:HGNC:17679
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MOG1; HSPC165; HSPC236; RANGNRF
    Summary
    This gene encodes a protein that has been shown to function as a guanine nucleotide release factor in mouse and to regulate the expression and function of the Nav1.5 cardiac sodium channel in human. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
    Expression
    Broad expression in testis (RPKM 13.3), endometrium (RPKM 7.1) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RANGRF in Genome Data Viewer
    Location:
    17p13.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (8288670..8290087)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (8194912..8196329)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (8191988..8193405)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene tRNA-Ile (anticodon AAT) 4-1 Neighboring gene CST telomere replication complex component 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11690 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8178 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11691 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:8152035-8152791 Neighboring gene phosphoribosylformylglycinamidine synthase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:8187618-8188118 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:8188119-8188619 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11692 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11693 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8179 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11694 Neighboring gene solute carrier family 25 member 35 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11695 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11696 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11697 Neighboring gene uncharacterized LOC124903915 Neighboring gene uncharacterized LOC124903914 Neighboring gene CRISPRi-validated cis-regulatory element chr17.641 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:8213553-8214053 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:8216427-8216928 Neighboring gene Rho guanine nucleotide exchange factor 15

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC110973, DKFZp686F02139

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables sodium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sodium channel regulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sodium channel regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables transmembrane transporter binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transmembrane transporter binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heart contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitotic spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein localization to cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein localization to cell surface IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein exit from endoplasmic reticulum IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of bundle of His cell action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cardiac muscle cell action potential involved in regulation of contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of heart rate TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of membrane depolarization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of membrane depolarization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of membrane depolarization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of membrane depolarization during cardiac muscle cell action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of membrane depolarization during cardiac muscle cell action potential TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of membrane potential IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of sodium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of sodium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of sodium ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of sodium ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of sodium ion transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in caveola IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in intercalated disc ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IC
    Inferred by Curator
    more info
    PubMed 
    located_in rough endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ran guanine nucleotide release factor
    Names
    MOG1 homolog
    ran-binding protein MOG1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028189.1 RefSeqGene

      Range
      5020..6437
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001177801.2NP_001171272.1  ran guanine nucleotide release factor isoform B

      See identical proteins and their annotated locations for NP_001171272.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) includes an alternate segment in the coding region, resulting in a frameshift, compared to variant (1). It encodes isoform B, which has a shorter C-terminus, compared to isoform A.
      Source sequence(s)
      AF265205, CN396019
      Consensus CDS
      CCDS54086.1
      UniProtKB/Swiss-Prot
      Q9HD47
      Related
      ENSP00000383940.4, ENST00000407006.8
      Conserved Domains (1) summary
      cd00224
      Location:7146
      Mog1; homolog to Ran-Binding Protein Mog1p; binds to the small GTPase Ran, which plays an important role in nuclear import. Binding is independent of Ran's nucleotide state (RanGTP/RanGDP)
    2. NM_001177802.2NP_001171273.1  ran guanine nucleotide release factor isoform C

      See identical proteins and their annotated locations for NP_001171273.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) includes an alternate segment in the coding region, resulting in a frameshift, compared to variant (1). It encodes isoform C, which has a shorter and distinct C-terminus, compared to isoform A.
      Source sequence(s)
      AC135178, BC006486, CN396019
      Consensus CDS
      CCDS54087.1
      UniProtKB/Swiss-Prot
      Q9HD47
      Related
      ENSP00000413190.3, ENST00000439238.3
      Conserved Domains (1) summary
      cl00169
      Location:7119
      Mog1; homolog to Ran-Binding Protein Mog1p; binds to the small GTPase Ran, which plays an important role in nuclear import. Binding is independent of Ran's nucleotide state (RanGTP/RanGDP)
    3. NM_001330127.2NP_001317056.1  ran guanine nucleotide release factor isoform D

      Status: REVIEWED

      Source sequence(s)
      AC135178, CR749387, HY034192
      Consensus CDS
      CCDS82066.1
      UniProtKB/Swiss-Prot
      Q9HD47
      Related
      ENSP00000462310.1, ENST00000580434.5
      Conserved Domains (1) summary
      cl00169
      Location:7117
      Mog1; homolog to Ran-Binding Protein Mog1p; binds to the small GTPase Ran, which plays an important role in nuclear import. Binding is independent of Ran's nucleotide state (RanGTP/RanGDP)
    4. NM_016492.5NP_057576.2  ran guanine nucleotide release factor isoform A

      See identical proteins and their annotated locations for NP_057576.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shortest transcript and encodes the longest isoform (A).
      Source sequence(s)
      AF265206, CN396019
      Consensus CDS
      CCDS11137.1
      UniProtKB/Swiss-Prot
      D3DTR6, Q68DI3, Q9BR68, Q9HD47, Q9HD48, Q9NRU9, Q9P001, Q9P0P2
      Related
      ENSP00000226105.6, ENST00000226105.11
      Conserved Domains (1) summary
      cd00224
      Location:7184
      Mog1; homolog to Ran-Binding Protein Mog1p; binds to the small GTPase Ran, which plays an important role in nuclear import. Binding is independent of Ran's nucleotide state (RanGTP/RanGDP)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      8288670..8290087
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      8194912..8196329
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)