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    GPR42 G protein-coupled receptor 42 [ Homo sapiens (human) ]

    Gene ID: 2866, updated on 2-Nov-2024

    Summary

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    Official Symbol
    GPR42provided by HGNC
    Official Full Name
    G protein-coupled receptor 42provided by HGNC
    Primary source
    HGNC:HGNC:4500
    See related
    Ensembl:ENSG00000126251 MIM:603822; AllianceGenome:HGNC:4500
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FFAR1L; FFAR3L; GPR41L; GPR42P
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See GPR42 in Genome Data Viewer
    Location:
    19q13.12
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (35371068..35372962)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (37915808..37917703)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (35861970..35863864)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene MPRA-validated peak3448 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14476 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14477 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:35843089-35843955 Neighboring gene free fatty acid receptor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10525 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35850683-35851210 Neighboring gene free fatty acid receptor 3 Neighboring gene CRISPRi-validated cis-regulatory element chr19.3689 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_51280 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 7 Neighboring gene long intergenic non-protein coding RNA 1531 Neighboring gene RNA, 7SL, cytoplasmic 491, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Human GPR42 is a transcribed multisite variant that exhibits copy number polymorphism and is functional when heterologously expressed. Puhl HL 3rd, et al. Sci Rep, 2015 Aug 11. PMID 26260360, Free PMC Article
    2. Sequence polymorphisms provide a common consensus sequence for GPR41 and GPR42. Liaw CW, et al. DNA Cell Biol, 2009 Nov. PMID 19630535
    3. A family of fatty acid binding receptors. Brown AJ, et al. DNA Cell Biol, 2005 Jan. PMID 15684720
    4. A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1. Sawzdargo M, et al. Biochem Biophys Res Commun, 1997 Oct 20. PMID 9344866
    5. The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. Brown AJ, et al. J Biol Chem, 2003 Mar 28. PMID 12496283

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NOT enables G protein-coupled receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables G protein-coupled receptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    NOT involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in G protein-coupled receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    G-protein coupled receptor 42
    Names
    G protein-coupled receptor 42 pseudogene
    G-protein coupled receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001348195.2 → NP_001335124.1  G-protein coupled receptor 42

      Status: VALIDATED

      Source sequence(s)
      AC002511
      Consensus CDS
      CCDS12460.1
      UniProtKB/Swiss-Prot
      O15529
      UniProtKB/TrEMBL
      A0A0K0PUY3, A0A0K0PV74
      Related
      ENSP00000410925.1, ENST00000454971.3
      Conserved Domains (1) summary
      cd15170
      Location:15 → 289
      7tmA_FFAR2_FFAR3; free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      35371068..35372962
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      37915808..37917703
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_008348.3: Suppressed sequence

      Description
      NG_008348.3: This RefSeq was removed because it is now thought that this gene does encode a protein.

    2. NM_005305.1: Suppressed sequence

      Description
      NM_005305.1: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O15529.2 GenPept UniProtKB/Swiss-Prot:O15529

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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    Research Materials