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    GPR42 G protein-coupled receptor 42 [ Homo sapiens (human) ]

    Gene ID: 2866, updated on 17-Jun-2024

    Summary

    Official Symbol
    GPR42provided by HGNC
    Official Full Name
    G protein-coupled receptor 42provided by HGNC
    Primary source
    HGNC:HGNC:4500
    See related
    Ensembl:ENSG00000126251 MIM:603822; AllianceGenome:HGNC:4500
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FFAR1L; FFAR3L; GPR41L; GPR42P
    Summary
    Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

    See GPR42 in Genome Data Viewer
    Location:
    19q13.12
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (35371068..35372962)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (37915808..37917703)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (35861970..35863864)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene MPRA-validated peak3448 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14476 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14477 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:35843089-35843955 Neighboring gene free fatty acid receptor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10525 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35850683-35851210 Neighboring gene free fatty acid receptor 3 Neighboring gene CRISPRi-validated cis-regulatory element chr19.3689 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_51280 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 7 Neighboring gene long intergenic non-protein coding RNA 1531 Neighboring gene RNA, 7SL, cytoplasmic 491, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    G-protein coupled receptor 42
    Names
    G protein-coupled receptor 42 pseudogene
    G-protein coupled receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001348195.2NP_001335124.1  G-protein coupled receptor 42

      Status: VALIDATED

      Source sequence(s)
      AC002511
      Consensus CDS
      CCDS12460.1
      UniProtKB/Swiss-Prot
      O15529
      UniProtKB/TrEMBL
      A0A0K0PUY3, A0A0K0PV74
      Related
      ENSP00000410925.1, ENST00000454971.3
      Conserved Domains (1) summary
      cd15170
      Location:15289
      7tmA_FFAR2_FFAR3; free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      35371068..35372962
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      37915808..37917703
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_008348.3: Suppressed sequence

      Description
      NG_008348.3: This RefSeq was removed because it is now thought that this gene does encode a protein.
    2. NM_005305.1: Suppressed sequence

      Description
      NM_005305.1: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.