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    GPR35 G protein-coupled receptor 35 [ Homo sapiens (human) ]

    Gene ID: 2859, updated on 26-Jul-2021

    Summary

    Official Symbol
    GPR35provided by HGNC
    Official Full Name
    G protein-coupled receptor 35provided by HGNC
    Primary source
    HGNC:HGNC:4492
    See related
    Ensembl:ENSG00000178623 MIM:602646
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Biased expression in duodenum (RPKM 17.7), small intestine (RPKM 16.7) and 7 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See GPR35 in Genome Data Viewer
    Location:
    2q37.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (240605430..240633159)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (241544847..241570670)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 5965 Neighboring gene CAPN10 divergent transcript Neighboring gene calpain 10 Neighboring gene galactose-3-O-sulfotransferase 1 pseudogene Neighboring gene aquaporin 12B

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Genome-wide association analysis in primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4.
    GeneReviews: Not available
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    GeneReviews: Not available
    Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
    GeneReviews: Not available

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: CAPN10

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables C-X-C chemokine receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables G protein-coupled receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    G-protein coupled receptor 35
    Names
    KYNA receptor
    kynurenic acid receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195381.3NP_001182310.1  G-protein coupled receptor 35 isoform b

      See identical proteins and their annotated locations for NP_001182310.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, and uses an alternate start codon, compared to variant 1. The resulting isoform (b, also known as GPR35b) is longer at the N-terminus, compared to isoform a. Variants 2-4 all encode the same isoform (b).
      Source sequence(s)
      AC124862
      Consensus CDS
      CCDS56174.1
      UniProtKB/Swiss-Prot
      Q9HC97
      Conserved Domains (1) summary
      pfam00001
      Location:74307
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    2. NM_001195382.3NP_001182311.1  G-protein coupled receptor 35 isoform b

      See identical proteins and their annotated locations for NP_001182311.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, and uses an alternate start codon, compared to variant 1. The resulting isoform (b, also known as GPR35b) is longer at the N-terminus, compared to isoform a. Variants 2-4 all encode the same isoform (b).
      Source sequence(s)
      AC124862
      Consensus CDS
      CCDS56174.1
      UniProtKB/Swiss-Prot
      Q9HC97
      UniProtKB/TrEMBL
      A8K2J1
      Related
      ENSP00000411788.2, ENST00000430267.2
      Conserved Domains (1) summary
      pfam00001
      Location:74307
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    3. NM_001394730.1NP_001381659.1  G-protein coupled receptor 35 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC124862
    4. NM_005301.5NP_005292.2  G-protein coupled receptor 35 isoform a

      See identical proteins and their annotated locations for NP_005292.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shortest transcript and encodes the shorter isoform (a, also known as GPR35a).
      Source sequence(s)
      AC124862
      Consensus CDS
      CCDS2541.1
      UniProtKB/Swiss-Prot
      Q9HC97
      UniProtKB/TrEMBL
      A8K2J1, B2RA17
      Related
      ENSP00000384263.1, ENST00000407714.1
      Conserved Domains (1) summary
      pfam00001
      Location:43276
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

      Range
      240605430..240633159
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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