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    Sh2d3c SH2 domain containing 3C [ Mus musculus (house mouse) ]

    Gene ID: 27387, updated on 11-Apr-2024

    Summary

    Official Symbol
    Sh2d3cprovided by MGI
    Official Full Name
    SH2 domain containing 3Cprovided by MGI
    Primary source
    MGI:MGI:1351631
    See related
    Ensembl:ENSMUSG00000059013 AllianceGenome:MGI:1351631
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Chat; Nsp3; Shep1
    Summary
    Predicted to enable transmembrane receptor protein tyrosine kinase adaptor activity. Predicted to be involved in positive regulation of peptidyl-serine phosphorylation. Predicted to act upstream of or within signal transduction. Predicted to be located in cell projection; cytoplasm; and plasma membrane. Orthologous to human SH2D3C (SH2 domain containing 3C). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in lung adult (RPKM 40.4), spleen adult (RPKM 34.7) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    Location:
    2 B; 2 22.09 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (32611072..32645008)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (32721037..32755007)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8785 Neighboring gene cyclin dependent kinase 9 Neighboring gene STARR-positive B cell enhancer ABC_E7807 Neighboring gene microRNA 3960 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:32577778-32577887 Neighboring gene predicted gene, 33457 Neighboring gene STARR-positive B cell enhancer ABC_E3368 Neighboring gene RIKEN cDNA 6330409D20 gene Neighboring gene STARR-positive B cell enhancer ABC_E411 Neighboring gene tetratricopeptide repeat domain 16 Neighboring gene torsin family 2, member A Neighboring gene STARR-positive B cell enhancer ABC_E10097 Neighboring gene cilia and flagella associated protein 157 Neighboring gene peptidyl-tRNA hydrolase 1 homolog

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC130521

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphotyrosine residue binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmembrane receptor protein tyrosine kinase adaptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    SH2 domain-containing protein 3C
    Names
    Cas/HEF1-associated signal transducer
    SH2 domain-containing Eph receptor-binding protein 1
    novel SH2-containing protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252547.2NP_001239476.1  SH2 domain-containing protein 3C isoform 2

      See identical proteins and their annotated locations for NP_001239476.1

      Status: VALIDATED

      Source sequence(s)
      AL772271
      Consensus CDS
      CCDS57168.1
      UniProtKB/Swiss-Prot
      Q9QZS8
      Related
      ENSMUSP00000108868.3, ENSMUST00000113242.5
      Conserved Domains (2) summary
      cd10337
      Location:56190
      SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
      cl02485
      Location:427604
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    2. NM_001412517.1NP_001399446.1  SH2 domain-containing protein 3C isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL772271
    3. NM_001412518.1NP_001399447.1  SH2 domain-containing protein 3C isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL772271
    4. NM_001412519.1NP_001399448.1  SH2 domain-containing protein 3C isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL772271
    5. NM_001412520.1NP_001399449.1  SH2 domain-containing protein 3C isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL772271
    6. NM_001412521.1NP_001399450.1  SH2 domain-containing protein 3C isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL772271
    7. NM_001412522.1NP_001399451.1  SH2 domain-containing protein 3C isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL772271
    8. NM_001412523.1NP_001399452.1  SH2 domain-containing protein 3C isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL772271
    9. NM_013781.4NP_038809.1  SH2 domain-containing protein 3C isoform 1

      See identical proteins and their annotated locations for NP_038809.1

      Status: VALIDATED

      Source sequence(s)
      AL772271
      Consensus CDS
      CCDS15928.1
      UniProtKB/Swiss-Prot
      A2AK84, Q9JME1, Q9QZS8
      Related
      ENSMUSP00000073866.5, ENSMUST00000074248.11
      Conserved Domains (2) summary
      cd10337
      Location:208342
      SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
      cl02485
      Location:579756
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      32611072..32645008
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498095.4XP_006498158.1  SH2 domain-containing protein 3C isoform X1

      Conserved Domains (2) summary
      cd10337
      Location:208342
      SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
      cl02485
      Location:565742
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    2. XM_006498096.2XP_006498159.1  SH2 domain-containing protein 3C isoform X5

      Conserved Domains (1) summary
      cl02485
      Location:230407
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    3. XM_036162272.1XP_036018165.1  SH2 domain-containing protein 3C isoform X4

      Conserved Domains (2) summary
      cd10337
      Location:55189
      SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
      cl02485
      Location:412589
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...