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    Mecr mitochondrial trans-2-enoyl-CoA reductase [ Mus musculus (house mouse) ]

    Gene ID: 26922, updated on 23-Jun-2021

    Summary

    Official Symbol
    Mecrprovided by MGI
    Official Full Name
    mitochondrial trans-2-enoyl-CoA reductaseprovided by MGI
    Primary source
    MGI:MGI:1349441
    See related
    Ensembl:ENSMUSG00000028910
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nrb; Nrbf1; NRBF-1; AI195831
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 11.0), colon adult (RPKM 9.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Mecr in Genome Data Viewer
    Location:
    4; 4 D2.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (131570755..131595098)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (131843444..131867787)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (131399386..131423702)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 42321 Neighboring gene protein tyrosine phosphatase, receptor type, U Neighboring gene predicted gene, 52680 Neighboring gene serine and arginine-rich splicing factor 4 Neighboring gene predicted gene 12992 Neighboring gene phosphatidylinositol 3-kinase, catalytic, beta polypeptide pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nuclear receptor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables trans-2-enoyl-CoA reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables trans-2-enoyl-CoA reductase (NADPH) activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    enoyl-[acyl-carrier-protein] reductase, mitochondrial
    Names
    2-enoyl thioester reductase
    nuclear receptor binding factor 1
    trans-2-enoyl-CoA reductase, mitochondrial
    NP_079573.2
    XP_006538948.1
    XP_006538952.1
    XP_011248563.1
    XP_011248564.1
    XP_011248565.1
    XP_036020030.1
    XP_036020031.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025297.2NP_079573.2  enoyl-[acyl-carrier-protein] reductase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_079573.2

      Status: VALIDATED

      Source sequence(s)
      AK002533, BQ746166, BY017691, BY693002
      Consensus CDS
      CCDS18715.1
      UniProtKB/Swiss-Prot
      Q9DCS3
      Related
      ENSMUSP00000030742.5, ENSMUST00000030742.11
      Conserved Domains (2) summary
      cd08290
      Location:44373
      ETR; 2-enoyl thioester reductase (ETR)
      COG0604
      Location:44350
      Qor; NADPH:quinone reductase or related Zn-dependent oxidoreductase [Energy production and conversion, General function prediction only]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      131570755..131595098
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538885.3XP_006538948.1  enoyl-[acyl-carrier-protein] reductase, mitochondrial isoform X1

      Conserved Domains (1) summary
      cd08290
      Location:44407
      ETR; 2-enoyl thioester reductase (ETR)
    2. XM_011250261.2XP_011248563.1  enoyl-[acyl-carrier-protein] reductase, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_011248563.1

      Conserved Domains (1) summary
      cd08290
      Location:22336
      ETR; 2-enoyl thioester reductase (ETR)
    3. XM_036164138.1XP_036020031.1  enoyl-[acyl-carrier-protein] reductase, mitochondrial isoform X3

      Conserved Domains (1) summary
      cd08290
      Location:1297
      ETR; 2-enoyl thioester reductase (ETR)
    4. XM_036164137.1XP_036020030.1  enoyl-[acyl-carrier-protein] reductase, mitochondrial isoform X3

      Conserved Domains (1) summary
      cd08290
      Location:1297
      ETR; 2-enoyl thioester reductase (ETR)
    5. XM_006538889.3XP_006538952.1  enoyl-[acyl-carrier-protein] reductase, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_006538952.1

      Conserved Domains (1) summary
      cd08290
      Location:22336
      ETR; 2-enoyl thioester reductase (ETR)
    6. XM_011250262.2XP_011248564.1  enoyl-[acyl-carrier-protein] reductase, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_011248564.1

      Conserved Domains (1) summary
      cd08290
      Location:22336
      ETR; 2-enoyl thioester reductase (ETR)
    7. XM_011250263.2XP_011248565.1  enoyl-[acyl-carrier-protein] reductase, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_011248565.1

      Conserved Domains (1) summary
      cd08290
      Location:22336
      ETR; 2-enoyl thioester reductase (ETR)

    RNA

    1. XR_001784148.2 RNA Sequence

    2. XR_001784149.1 RNA Sequence

    3. XR_003954954.1 RNA Sequence

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