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    Cyb5r4 cytochrome b5 reductase 4 [ Mus musculus (house mouse) ]

    Gene ID: 266690, updated on 23-Jun-2021

    Summary

    Official Symbol
    Cyb5r4provided by MGI
    Official Full Name
    cytochrome b5 reductase 4provided by MGI
    Primary source
    MGI:MGI:2386848
    See related
    Ensembl:ENSMUSG00000032872
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ncb; B5+B5; b5/b5; b5b5r; B5+B5R; C79736; Ncb5or; b5/b5r; Cb5cb5r; 2810034J18Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 10.7), bladder adult (RPKM 10.6) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cyb5r4 in Genome Data Viewer
    Location:
    9; 9 E3.1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (86904061..86959827)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (87022008..87077774)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (86916864..86972609)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39389 Neighboring gene predicted gene, 36539 Neighboring gene ripply transcriptional repressor 2 Neighboring gene predicted gene 8282 Neighboring gene melanocortin 2 receptor accessory protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NADPH-hemoprotein reductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cytochrome-b5 reductase activity, acting on NAD(P)H IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cytochrome-b5 reductase activity, acting on NAD(P)H IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cytochrome-b5 reductase activity, acting on NAD(P)H ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables flavin adenine dinucleotide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables heme binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cytochrome b5 reductase 4
    Names
    N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein
    NADPH cytochrome B5 oxidoreductase
    cb5/cb5R
    cytochrome b-type NAD(P)H oxidoreductase
    flavohemoprotein b5/b5R
    NP_001346891.1
    NP_077157.2
    XP_006511263.1
    XP_030100254.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359962.1NP_001346891.1  cytochrome b5 reductase 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC156793, CO801035
      Conserved Domains (3) summary
      cd06183
      Location:285475
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
      cd06490
      Location:177263
      p23_NCB5OR; p23_like domain found in NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR) and similar proteins. NCB5OR is widely expressed in human organs and tissues and is localized in the ER (endoplasmic reticulum). It appears to play a critical role in maintaining ...
      pfam00173
      Location:58130
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
    2. NM_024195.2NP_077157.2  cytochrome b5 reductase 4 isoform 1

      See identical proteins and their annotated locations for NP_077157.2

      Status: VALIDATED

      Source sequence(s)
      AK090159, CO801035
      Consensus CDS
      CCDS40716.2
      UniProtKB/Swiss-Prot
      Q3TDX8
      Related
      ENSMUSP00000126119.3, ENSMUST00000168529.9
      Conserved Domains (3) summary
      cd06183
      Location:285526
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
      cd06490
      Location:177263
      p23_NCB5OR; p23_like domain found in NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR) and similar proteins. NCB5OR is widely expressed in human organs and tissues and is localized in the ER (endoplasmic reticulum). It appears to play a critical role in maintaining ...
      pfam00173
      Location:56128
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      86904061..86959827
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244394.1XP_030100254.1  cytochrome b5 reductase 4 isoform X2

      Conserved Domains (3) summary
      cd06183
      Location:233423
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
      pfam00173
      Location:58130
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
      cl00175
      Location:177228
      alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.
    2. XM_006511200.3XP_006511263.1  cytochrome b5 reductase 4 isoform X1

      Conserved Domains (3) summary
      cd06183
      Location:233474
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
      pfam00173
      Location:58130
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
      cl00175
      Location:177228
      alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.
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