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    GDF10 growth differentiation factor 10 [ Homo sapiens (human) ]

    Gene ID: 2662, updated on 5-Mar-2024

    Summary

    Official Symbol
    GDF10provided by HGNC
    Official Full Name
    growth differentiation factor 10provided by HGNC
    Primary source
    HGNC:HGNC:4215
    See related
    Ensembl:ENSG00000266524 MIM:601361; AllianceGenome:HGNC:4215
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BIP; BMP3B; BMP-3b
    Summary
    This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This promotes neural repair after stroke. Additionally, this protein may act as a tumor suppressor and reduced expression of this gene is associated with oral cancer. [provided by RefSeq, Jul 2016]
    Expression
    Biased expression in lung (RPKM 8.6), fat (RPKM 5.4) and 12 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See GDF10 in Genome Data Viewer
    Location:
    10q11.22
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (47300197..47313577)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (48191293..48204673)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (48425785..48439165, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase non-receptor type 20 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:48600992-48602191 Neighboring gene NANOG hESC enhancer GRCh37_chr10:48563688-48564189 Neighboring gene uncharacterized LOC105378291 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:48510376-48510765 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2353 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:48473688-48474887 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:48460575-48461276 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:48456799-48457326 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:48456269-48456798 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:48428532-48429032 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:48426933-48427433 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:48402901-48403401 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:48396170-48396832 Neighboring gene growth differentiation factor 2 Neighboring gene retinol binding protein 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cerebellum development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ovulation cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of osteoblast differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of ossification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to kainic acid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in skeletal system development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in transforming growth factor beta receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    growth/differentiation factor 10
    Names
    bone morphogenetic protein 3B
    bone-inducing protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_046893.1 RefSeqGene

      Range
      4974..18354
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_004962.5NP_004953.1  growth/differentiation factor 10 preproprotein

      See identical proteins and their annotated locations for NP_004953.1

      Status: REVIEWED

      Source sequence(s)
      AL731561, BU678075, D49492, DA165700
      Consensus CDS
      CCDS73117.1
      UniProtKB/Swiss-Prot
      P55107, Q5VSQ8, Q9UCX6
      Related
      ENSP00000464145.1, ENST00000580279.2
      Conserved Domains (1) summary
      pfam00019
      Location:374477
      TGF_beta; Transforming growth factor beta like domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      47300197..47313577
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      48191293..48204673
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)