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    TMEM186 transmembrane protein 186 [ Homo sapiens (human) ]

    Gene ID: 25880, updated on 5-Mar-2024

    Summary

    Official Symbol
    TMEM186provided by HGNC
    Official Full Name
    transmembrane protein 186provided by HGNC
    Primary source
    HGNC:HGNC:24530
    See related
    Ensembl:ENSG00000184857 MIM:620433; AllianceGenome:HGNC:24530
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C16orf51
    Summary
    This gene encodes a potential transmembrane protein. [provided by RefSeq, Dec 2012]
    Expression
    Ubiquitous expression in kidney (RPKM 5.1), colon (RPKM 4.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TMEM186 in Genome Data Viewer
    Location:
    16p13.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (8795180..8797639, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (8827933..8830391, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (8889037..8891496, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene 4-aminobutyrate aminotransferase Neighboring gene RNA, U7 small nuclear 63 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:8813960-8814460 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:8821022-8821250 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr16:8825911-8826496 Neighboring gene uncharacterized LOC107984840 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:8845208-8845952 Neighboring gene uncharacterized LOC124903642 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7177 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:8891090-8891784 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:8891785-8892479 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7178 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7179 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7180 Neighboring gene phosphomannomutase 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:8923335-8923936 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:8929774-8930308 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:8930309-8930841 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:8940347-8940938 Neighboring gene uncharacterized LOC100130283 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10354 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:8953773-8954487 Neighboring gene calcium regulated heat stable protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp564K2062

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in mitochondrial inner membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033146.1 RefSeqGene

      Range
      5010..7469
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_015421.4NP_056236.2  transmembrane protein 186

      See identical proteins and their annotated locations for NP_056236.2

      Status: VALIDATED

      Source sequence(s)
      AC012173, BG682191, CA433910
      Consensus CDS
      CCDS10535.1
      UniProtKB/Swiss-Prot
      B2RAY0, Q96B77, Q9Y4T4
      Related
      ENSP00000331640.6, ENST00000333050.7

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      8795180..8797639 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      8827933..8830391 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)