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    EPHX4 epoxide hydrolase 4 [ Homo sapiens (human) ]

    Gene ID: 253152, updated on 5-Mar-2024

    Summary

    Official Symbol
    EPHX4provided by HGNC
    Official Full Name
    epoxide hydrolase 4provided by HGNC
    Primary source
    HGNC:HGNC:23758
    See related
    Ensembl:ENSG00000172031 MIM:617401; AllianceGenome:HGNC:23758
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EH4; ABHD7; EPHXRP
    Summary
    Predicted to enable hydrolase activity. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in brain (RPKM 5.0), thyroid (RPKM 1.1) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See EPHX4 in Genome Data Viewer
    Location:
    1p22.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (92029985..92063538)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (91874824..91908391)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (92495542..92529095)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene transforming growth factor beta receptor 3 Neighboring gene RNA, 7SL, cytoplasmic 653, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:92333973-92334474 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:92334475-92334974 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1310 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr1:92350516-92351279 and GRCh37_chr1:92351280-92352042 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:92359890-92360390 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:92371721-92372221 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:92376156-92376656 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:92376657-92377157 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:92407032-92407718 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:92407719-92408404 Neighboring gene bromodomain testis associated Neighboring gene uncharacterized LOC124904218 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:92495241-92495742 Neighboring gene lysophosphatidylcholine acyltransferase 2b, pseudogene Neighboring gene SET like protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ90341

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables epoxide hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    epoxide hydrolase 4
    Names
    abhydrolase domain containing 7
    abhydrolase domain-containing protein 7
    epoxide hydrolase-related protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173567.5NP_775838.3  epoxide hydrolase 4

      See identical proteins and their annotated locations for NP_775838.3

      Status: VALIDATED

      Source sequence(s)
      AC104836, AK074822, BC041475, DB475492
      Consensus CDS
      CCDS736.1
      UniProtKB/Swiss-Prot
      Q8IUS5, Q8NCC6
      Related
      ENSP00000359410.4, ENST00000370383.5
      Conserved Domains (1) summary
      COG0596
      Location:76350
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      92029985..92063538
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      91874824..91908391
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)