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    Enox1 ecto-NOX disulfide-thiol exchanger 1 [ Mus musculus (house mouse) ]

    Gene ID: 239188, updated on 23-Jun-2021

    Summary

    Official Symbol
    Enox1provided by MGI
    Official Full Name
    ecto-NOX disulfide-thiol exchanger 1provided by MGI
    Primary source
    MGI:MGI:2444896
    See related
    Ensembl:ENSMUSG00000022012
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B230207J08; D230005D02Rik
    Expression
    Biased expression in CNS E18 (RPKM 4.8), CNS E14 (RPKM 4.6) and 11 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Enox1 in Genome Data Viewer
    Location:
    14; 14 D3
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (77393790..77959203)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (77156248..77721763)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (77556623..78121214)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene coiled-coil domain containing 122 Neighboring gene laccase domain containing 1 Neighboring gene ribosomal protein L23A pseudogene Neighboring gene predicted gene, 41217 Neighboring gene predicted gene 6994 Neighboring gene predicted gene, 23823 Neighboring gene predicted gene, 52115 Neighboring gene predicted gene, 30467 Neighboring gene predicted gene 1587

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NADH dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein disulfide isomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-disulfide reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    acts_upstream_of_or_within rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ultradian rhythm IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ecto-NOX disulfide-thiol exchanger 1
    Names
    cNOX
    constitutive Ecto-NOX

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001253759.1NP_001240688.1  ecto-NOX disulfide-thiol exchanger 1 isoform 1

      See identical proteins and their annotated locations for NP_001240688.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK051821, AK082388, BC052062
      Consensus CDS
      CCDS88717.1
      UniProtKB/Swiss-Prot
      Q8BHR2
      Related
      ENSMUSP00000154512.2, ENSMUST00000227662.2
      Conserved Domains (2) summary
      cd12228
      Location:136219
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
      TIGR02168
      Location:307601
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    2. NM_172813.3NP_766401.1  ecto-NOX disulfide-thiol exchanger 1 isoform 2

      See identical proteins and their annotated locations for NP_766401.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AK051821, AK082388, BC052062
      Consensus CDS
      CCDS27290.1
      UniProtKB/Swiss-Prot
      Q8BHR2
      Related
      ENSMUSP00000022589.8, ENSMUST00000022589.9
      Conserved Domains (2) summary
      TIGR02168
      Location:291582
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd12228
      Location:136219
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      77393790..77959203
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247809.2XP_030103669.1  ecto-NOX disulfide-thiol exchanger 1 isoform X6

      Conserved Domains (2) summary
      COG1196
      Location:448607
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd12228
      Location:135218
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    2. XM_011245067.4XP_011243369.1  ecto-NOX disulfide-thiol exchanger 1 isoform X4

      Conserved Domains (2) summary
      COG1196
      Location:449608
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd12228
      Location:136219
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    3. XM_006519001.5XP_006519064.1  ecto-NOX disulfide-thiol exchanger 1 isoform X1

      See identical proteins and their annotated locations for XP_006519064.1

      UniProtKB/Swiss-Prot
      Q8BHR2
      Conserved Domains (2) summary
      cd12228
      Location:136219
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
      TIGR02168
      Location:307601
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    4. XM_030247806.2XP_030103666.1  ecto-NOX disulfide-thiol exchanger 1 isoform X3

      Conserved Domains (2) summary
      TIGR02168
      Location:291582
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd12228
      Location:136219
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    5. XM_030247812.2XP_030103672.1  ecto-NOX disulfide-thiol exchanger 1 isoform X7

      Conserved Domains (2) summary
      cd12228
      Location:136219
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
      TIGR02168
      Location:319550
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    6. XM_030247801.2XP_030103661.1  ecto-NOX disulfide-thiol exchanger 1 isoform X1

      Conserved Domains (2) summary
      cd12228
      Location:136219
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
      TIGR02168
      Location:307601
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    7. XM_036158592.1XP_036014485.1  ecto-NOX disulfide-thiol exchanger 1 isoform X3

      Conserved Domains (2) summary
      TIGR02168
      Location:291582
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd12228
      Location:136219
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    8. XM_036158596.1XP_036014489.1  ecto-NOX disulfide-thiol exchanger 1 isoform X10

      Conserved Domains (2) summary
      COG1196
      Location:289514
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd12228
      Location:136219
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    9. XM_030247804.2XP_030103664.1  ecto-NOX disulfide-thiol exchanger 1 isoform X2

      Conserved Domains (2) summary
      cd12228
      Location:135218
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
      TIGR02168
      Location:306600
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    10. XM_030247808.2XP_030103668.1  ecto-NOX disulfide-thiol exchanger 1 isoform X5

      Conserved Domains (2) summary
      TIGR02168
      Location:290581
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd12228
      Location:135218
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    11. XM_030247813.2XP_030103673.1  ecto-NOX disulfide-thiol exchanger 1 isoform X8

      Conserved Domains (2) summary
      cd12228
      Location:135218
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
      TIGR02168
      Location:318549
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    12. XM_030247800.2XP_030103660.1  ecto-NOX disulfide-thiol exchanger 1 isoform X1

      Conserved Domains (2) summary
      cd12228
      Location:136219
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
      TIGR02168
      Location:307601
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    13. XM_030247803.2XP_030103663.1  ecto-NOX disulfide-thiol exchanger 1 isoform X1

      Conserved Domains (2) summary
      cd12228
      Location:136219
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
      TIGR02168
      Location:307601
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    14. XM_006519000.5XP_006519063.1  ecto-NOX disulfide-thiol exchanger 1 isoform X1

      See identical proteins and their annotated locations for XP_006519063.1

      UniProtKB/Swiss-Prot
      Q8BHR2
      Conserved Domains (2) summary
      cd12228
      Location:136219
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
      TIGR02168
      Location:307601
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    15. XM_017316018.3XP_017171507.1  ecto-NOX disulfide-thiol exchanger 1 isoform X3

      UniProtKB/Swiss-Prot
      Q8BHR2
      Conserved Domains (2) summary
      TIGR02168
      Location:291582
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd12228
      Location:136219
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    16. XM_030247811.2XP_030103671.1  ecto-NOX disulfide-thiol exchanger 1 isoform X7

      Conserved Domains (2) summary
      cd12228
      Location:136219
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
      TIGR02168
      Location:319550
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    17. XM_006519006.5XP_006519069.1  ecto-NOX disulfide-thiol exchanger 1 isoform X2

      See identical proteins and their annotated locations for XP_006519069.1

      Conserved Domains (2) summary
      cd12228
      Location:135218
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
      TIGR02168
      Location:306600
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    18. XM_030247802.2XP_030103662.1  ecto-NOX disulfide-thiol exchanger 1 isoform X1

      Conserved Domains (2) summary
      cd12228
      Location:136219
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
      TIGR02168
      Location:307601
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    19. XM_036158593.1XP_036014486.1  ecto-NOX disulfide-thiol exchanger 1 isoform X5

      Conserved Domains (2) summary
      TIGR02168
      Location:290581
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd12228
      Location:135218
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    20. XM_011245064.4XP_011243366.1  ecto-NOX disulfide-thiol exchanger 1 isoform X1

      See identical proteins and their annotated locations for XP_011243366.1

      UniProtKB/Swiss-Prot
      Q8BHR2
      Conserved Domains (2) summary
      cd12228
      Location:136219
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
      TIGR02168
      Location:307601
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    21. XM_006518999.5XP_006519062.1  ecto-NOX disulfide-thiol exchanger 1 isoform X1

      See identical proteins and their annotated locations for XP_006519062.1

      UniProtKB/Swiss-Prot
      Q8BHR2
      Conserved Domains (2) summary
      cd12228
      Location:136219
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
      TIGR02168
      Location:307601
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    22. XM_011245066.4XP_011243368.1  ecto-NOX disulfide-thiol exchanger 1 isoform X3

      See identical proteins and their annotated locations for XP_011243368.1

      UniProtKB/Swiss-Prot
      Q8BHR2
      Conserved Domains (2) summary
      TIGR02168
      Location:291582
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd12228
      Location:136219
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    23. XM_030247810.2XP_030103670.1  ecto-NOX disulfide-thiol exchanger 1 isoform X7

      Conserved Domains (2) summary
      cd12228
      Location:136219
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
      TIGR02168
      Location:319550
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    24. XM_036158594.1XP_036014487.1  ecto-NOX disulfide-thiol exchanger 1 isoform X9

      Conserved Domains (2) summary
      pfam05483
      Location:263492
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      cd12228
      Location:136219
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    25. XM_036158595.1XP_036014488.1  ecto-NOX disulfide-thiol exchanger 1 isoform X10

      Conserved Domains (2) summary
      COG1196
      Location:289514
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd12228
      Location:136219
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    26. XM_006519005.5XP_006519068.1  ecto-NOX disulfide-thiol exchanger 1 isoform X2

      See identical proteins and their annotated locations for XP_006519068.1

      Conserved Domains (2) summary
      cd12228
      Location:135218
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
      TIGR02168
      Location:306600
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    27. XM_030247807.2XP_030103667.1  ecto-NOX disulfide-thiol exchanger 1 isoform X5

      Conserved Domains (2) summary
      TIGR02168
      Location:290581
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd12228
      Location:135218
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    28. XM_011245063.4XP_011243365.1  ecto-NOX disulfide-thiol exchanger 1 isoform X1

      See identical proteins and their annotated locations for XP_011243365.1

      UniProtKB/Swiss-Prot
      Q8BHR2
      Conserved Domains (2) summary
      cd12228
      Location:136219
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
      TIGR02168
      Location:307601
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RNA

    1. XR_383180.4 RNA Sequence

    2. XR_003950854.2 RNA Sequence

    3. XR_004938398.1 RNA Sequence

    4. XR_003950851.2 RNA Sequence

    5. XR_004938397.1 RNA Sequence

    6. XR_003950849.2 RNA Sequence

    7. XR_383179.4 RNA Sequence

    8. XR_004938399.1 RNA Sequence

    9. XR_003950850.2 RNA Sequence

    10. XR_004938396.1 RNA Sequence

    11. XR_001781120.3 RNA Sequence

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