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    Fbxl19 F-box and leucine-rich repeat protein 19 [ Mus musculus (house mouse) ]

    Gene ID: 233902, updated on 4-Nov-2018

    Summary

    Official Symbol
    Fbxl19provided by MGI
    Official Full Name
    F-box and leucine-rich repeat protein 19provided by MGI
    Primary source
    MGI:MGI:3039600
    See related
    Ensembl:ENSMUSG00000030811 Vega:OTTMUSG00000046248
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fbl19; BC059812; 6030430O11
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 27.2), CNS E11.5 (RPKM 26.6) and 26 other tissues See more
    Orthologs

    Genomic context

    See Fbxl19 in Genome Data Viewer
    Location:
    7; 7 F3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (127743957..127769483)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (134890289..134912442)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene cardiotrophin 1 Neighboring gene cardiotrophin 2 Neighboring gene ORAI calcium release-activated calcium modulator 3 Neighboring gene SET domain containing 1A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    F-box/LRR-repeat protein 19

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172748.2NP_766336.2  F-box/LRR-repeat protein 19

      See identical proteins and their annotated locations for NP_766336.2

      Status: PROVISIONAL

      Source sequence(s)
      BC059812
      Consensus CDS
      CCDS21877.1
      UniProtKB/Swiss-Prot
      Q6PB97
      Related
      ENSMUSP00000033081.7, OTTMUSP00000066709, ENSMUST00000033081.13, OTTMUST00000120586
      Conserved Domains (6) summary
      pfam02008
      Location:3057
      zf-CXXC; CXXC zinc finger domain
      sd00034
      Location:466489
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15645
      Location:67128
      PHD_FXL19; PHD finger found in F-box and leucine-rich repeat protein 19 (FBXL19)
      pfam12937
      Location:404445
      F-box-like; F-box-like
      cl26464
      Location:176408
      Atrophin-1; Atrophin-1 family
      cl28166
      Location:446645
      AMN1; Antagonist of mitotic exit network protein 1

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      127743957..127769483
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241782.2XP_011240084.1  F-box/LRR-repeat protein 19 isoform X2

      See identical proteins and their annotated locations for XP_011240084.1

      Conserved Domains (5) summary
      cd09293
      Location:468667
      AMN1; Antagonist of mitotic exit network protein 1
      pfam02008
      Location:5279
      zf-CXXC; CXXC zinc finger domain
      sd00034
      Location:488511
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15645
      Location:89150
      PHD_FXL19; PHD finger found in F-box and leucine-rich repeat protein 19 (FBXL19)
      pfam12937
      Location:426469
      F-box-like; F-box-like
    2. XM_006507753.3XP_006507816.1  F-box/LRR-repeat protein 19 isoform X2

      See identical proteins and their annotated locations for XP_006507816.1

      Conserved Domains (5) summary
      cd09293
      Location:468667
      AMN1; Antagonist of mitotic exit network protein 1
      pfam02008
      Location:5279
      zf-CXXC; CXXC zinc finger domain
      sd00034
      Location:488511
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15645
      Location:89150
      PHD_FXL19; PHD finger found in F-box and leucine-rich repeat protein 19 (FBXL19)
      pfam12937
      Location:426469
      F-box-like; F-box-like
    3. XM_006507752.2XP_006507815.2  F-box/LRR-repeat protein 19 isoform X1

      Conserved Domains (5) summary
      pfam02008
      Location:4370
      zf-CXXC; CXXC zinc finger domain
      sd00034
      Location:479502
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15645
      Location:80141
      PHD_FXL19; PHD finger found in F-box and leucine-rich repeat protein 19 (FBXL19)
      pfam12937
      Location:417458
      F-box-like; F-box-like
      cl28166
      Location:459658
      AMN1; Antagonist of mitotic exit network protein 1
    4. XM_006507754.2XP_006507817.2  F-box/LRR-repeat protein 19 isoform X3

      Related
      ENSMUSP00000145616.1, OTTMUSP00000075059, ENSMUST00000206893.1, OTTMUST00000143973
      Conserved Domains (6) summary
      pfam02008
      Location:4370
      zf-CXXC; CXXC zinc finger domain
      sd00034
      Location:436459
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15645
      Location:80141
      PHD_FXL19; PHD finger found in F-box and leucine-rich repeat protein 19 (FBXL19)
      pfam12937
      Location:374415
      F-box-like; F-box-like
      cl25642
      Location:152266
      DUF390; Protein of unknown function (DUF390)
      cl28166
      Location:416615
      AMN1; Antagonist of mitotic exit network protein 1
    5. XM_006507755.2XP_006507818.2  F-box/LRR-repeat protein 19 isoform X4

      Conserved Domains (5) summary
      pfam02008
      Location:4370
      zf-CXXC; CXXC zinc finger domain
      sd00034
      Location:406429
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15645
      Location:80141
      PHD_FXL19; PHD finger found in F-box and leucine-rich repeat protein 19 (FBXL19)
      pfam12937
      Location:344385
      F-box-like; F-box-like
      cl28166
      Location:386585
      AMN1; Antagonist of mitotic exit network protein 1
    6. XM_006507756.2XP_006507819.2  F-box/LRR-repeat protein 19 isoform X5

      Related
      ENSMUSP00000140021.1, OTTMUSP00000066710, ENSMUST00000188580.2, OTTMUST00000120587
      Conserved Domains (5) summary
      pfam02008
      Location:4370
      zf-CXXC; CXXC zinc finger domain
      sd00034
      Location:363386
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15645
      Location:80141
      PHD_FXL19; PHD finger found in F-box and leucine-rich repeat protein 19 (FBXL19)
      pfam12937
      Location:301342
      F-box-like; F-box-like
      cl28166
      Location:343542
      AMN1; Antagonist of mitotic exit network protein 1
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