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    Fbxl19 F-box and leucine-rich repeat protein 19 [ Mus musculus (house mouse) ]

    Gene ID: 233902, updated on 23-Jun-2021

    Summary

    Official Symbol
    Fbxl19provided by MGI
    Official Full Name
    F-box and leucine-rich repeat protein 19provided by MGI
    Primary source
    MGI:MGI:3039600
    See related
    Ensembl:ENSMUSG00000030811
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fbl1; Fbl19; BC059812; 6030430O11
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 27.2), CNS E11.5 (RPKM 26.6) and 26 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Fbxl19 in Genome Data Viewer
    Location:
    7; 7 F3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (127343059..127368655)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127743887..127769483)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (134890289..134912442)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene cardiotrophin 1 Neighboring gene cardiotrophin 2 Neighboring gene predicted gene, 53374 Neighboring gene ORAI calcium release-activated calcium modulator 3 Neighboring gene SET domain containing 1A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone demethylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables unmethylated CpG binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    F-box/LRR-repeat protein 19

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001374793.1NP_001361722.1  F-box/LRR-repeat protein 19 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC149222
      Consensus CDS
      CCDS90334.1
      Related
      ENSMUSP00000145616.2, ENSMUST00000206893.2
      Conserved Domains (6) summary
      cd09293
      Location:403602
      AMN1; Antagonist of mitotic exit network protein 1
      PHA03247
      Location:172365
      PHA03247; large tegument protein UL36; Provisional
      sd00034
      Location:423446
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15645
      Location:67128
      PHD_FXL19; PHD finger found in F-box and leucine-rich repeat protein 19 (FBXL19)
      pfam02008
      Location:3057
      zf-CXXC; CXXC zinc finger domain
      pfam12937
      Location:361402
      F-box-like
    2. NM_172748.2NP_766336.2  F-box/LRR-repeat protein 19 isoform 1

      See identical proteins and their annotated locations for NP_766336.2

      Status: VALIDATED

      Source sequence(s)
      BC059812
      Consensus CDS
      CCDS21877.1
      UniProtKB/Swiss-Prot
      Q6PB97
      Related
      ENSMUSP00000033081.8, ENSMUST00000033081.14
      Conserved Domains (6) summary
      cd09293
      Location:446645
      AMN1; Antagonist of mitotic exit network protein 1
      PHA03247
      Location:176408
      PHA03247; large tegument protein UL36; Provisional
      sd00034
      Location:466489
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15645
      Location:67128
      PHD_FXL19; PHD finger found in F-box and leucine-rich repeat protein 19 (FBXL19)
      pfam02008
      Location:3057
      zf-CXXC; CXXC zinc finger domain
      pfam12937
      Location:404445
      F-box-like

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      127343059..127368655
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153020.1XP_036008913.1  F-box/LRR-repeat protein 19 isoform X1

      Conserved Domains (5) summary
      cd09293
      Location:468667
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:488511
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15645
      Location:89150
      PHD_FXL19; PHD finger found in F-box and leucine-rich repeat protein 19 (FBXL19)
      pfam02008
      Location:5279
      zf-CXXC; CXXC zinc finger domain
      pfam12937
      Location:426467
      F-box-like
    2. XM_036153021.1XP_036008914.1  F-box/LRR-repeat protein 19 isoform X2

      Conserved Domains (5) summary
      cd09293
      Location:425624
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:445468
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15645
      Location:89150
      PHD_FXL19; PHD finger found in F-box and leucine-rich repeat protein 19 (FBXL19)
      pfam02008
      Location:5279
      zf-CXXC; CXXC zinc finger domain
      pfam12937
      Location:383424
      F-box-like
    3. XM_030242537.2XP_030098397.1  F-box/LRR-repeat protein 19 isoform X3

      Conserved Domains (5) summary
      cd09293
      Location:373572
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:393416
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15645
      Location:67128
      PHD_FXL19; PHD finger found in F-box and leucine-rich repeat protein 19 (FBXL19)
      pfam02008
      Location:3057
      zf-CXXC; CXXC zinc finger domain
      pfam12937
      Location:331372
      F-box-like
    4. XM_006507756.3XP_006507819.3  F-box/LRR-repeat protein 19 isoform X4

      Related
      ENSMUSP00000140021.2, ENSMUST00000188580.3
      Conserved Domains (5) summary
      cd09293
      Location:330529
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:350373
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15645
      Location:67128
      PHD_FXL19; PHD finger found in F-box and leucine-rich repeat protein 19 (FBXL19)
      pfam02008
      Location:3057
      zf-CXXC; CXXC zinc finger domain
      pfam12937
      Location:288329
      F-box-like
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