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    ARHGEF18 Rho/Rac guanine nucleotide exchange factor 18 [ Homo sapiens (human) ]

    Gene ID: 23370, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ARHGEF18provided by HGNC
    Official Full Name
    Rho/Rac guanine nucleotide exchange factor 18provided by HGNC
    Primary source
    HGNC:HGNC:17090
    See related
    Ensembl:ENSG00000104880 MIM:616432; AllianceGenome:HGNC:17090
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RP78; SA-RhoGEF; p114RhoGEF; P114-RhoGEF
    Summary
    Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of guanine nucleotide exchange factors (GEFs). The protein encoded by this gene is a guanine nucleotide exchange factor and belongs to the Rho GTPase GEF family. Family members share a common feature, a Dbl (DH) homology domain followed by a pleckstrin (PH) homology domain. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Nov 2018]
    Expression
    Ubiquitous expression in spleen (RPKM 12.9), lymph node (RPKM 11.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ARHGEF18 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (7348937..7479989)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (7341415..7480103)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (7413842..7537364)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904625 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9971 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:7103011-7103510 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:7102509-7103010 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:7109747-7110266 Neighboring gene MPRA-validated peak3314 silencer Neighboring gene insulin receptor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13870 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13871 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13872 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:7197359-7198195 Neighboring gene uncharacterized LOC124904626 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:7212577-7213123 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr19:7213124-7213669 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13874 Neighboring gene MPRA-validated peak3317 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:7257400-7258262 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:7288463-7288964 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:7292867-7293625 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9973 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9974 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9975 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9976 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9977 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13875 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13876 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13877 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13878 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13879 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9978 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:7439323-7439927 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:7438718-7439322 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13880 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:7447849-7448349 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13881 Neighboring gene ARHGEF18 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:7459704-7460144 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13882 Neighboring gene MPRA-validated peak3319 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:7462888-7463393 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:7463394-7463898 Neighboring gene MPRA-validated peak3320 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9980 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13883 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13884 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13885 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13886 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:7501123-7501310 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:7515146-7515690 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:7515691-7516233 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9981 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:7541732-7542367 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:7548591-7549112 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9982 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9983 Neighboring gene Sharpr-MPRA regulatory region 6634 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9984 Neighboring gene Sharpr-MPRA regulatory region 11228 Neighboring gene peroxisomal biogenesis factor 11 gamma Neighboring gene uncharacterized LOC105372261 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9985 Neighboring gene stabilizer of axonemal microtubules 5 Neighboring gene zinc finger protein 358

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Expression of novel "LOCGEF" isoforms of ARHGEF18 in eosinophils. Turton KB, et al. J Leukoc Biol, 2018 Jul. PMID 29601110, Free PMC Article
    2. Association between a Single Nucleotide Polymorphism in the 3'-UTR of ARHGEF18 and the Risk of Nonidiopathic Pulmonary Arterial Hypertension in Chinese Population. Li D, et al. Dis Markers, 2018. PMID 30405854, Free PMC Article
    3. Stimulation of cortical myosin phosphorylation by p114RhoGEF drives cell migration and tumor cell invasion. Terry SJ, et al. PLoS One, 2012. PMID 23185572, Free PMC Article
    4. Identification and characterization of a novel Rho-specific guanine nucleotide exchange factor. Blomquist A, et al. Biochem J, 2000 Dec 1. PMID 11085924, Free PMC Article
    5. Biallelic Mutation of ARHGEF18, Involved in the Determination of Epithelial Apicobasal Polarity, Causes Adult-Onset Retinal Degeneration. Arno G, et al. Am J Hum Genet, 2017 Feb 2. PMID 28132693, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We suggest that a portion of a 1361-residue isoform of ARHGEF18, which is unlike any other protein domain, has unique functions in control of polarity in activated eosinophils and other leukocytes
      Title: Expression of novel "LOCGEF" isoforms of ARHGEF18 in eosinophils.
    2. ARHGEF18 rs3745357 variant is associated with nonidiopathic pulmonary arterial hypertension susceptibility in Chinese population.
      Title: Association between a Single Nucleotide Polymorphism in the 3'-UTR of ARHGEF18 and the Risk of Nonidiopathic Pulmonary Arterial Hypertension in Chinese Population.
    3. mutation of ARHGEF18 is a likely cause of inherited retinal dystrophy
      Title: Biallelic Mutation of ARHGEF18, Involved in the Determination of Epithelial Apicobasal Polarity, Causes Adult-Onset Retinal Degeneration.
    4. CRB3A recruits p114RhoGEF and its activator Ehm2 to the cell periphery using both functional motifs of its cytoplasmic tail and increases RhoA activation levels.
      Title: CRB3A Controls the Morphology and Cohesion of Cancer Cells through Ehm2/p114RhoGEF-Dependent Signaling.
    5. LKB1 and p114RhoGEF control RhoA activity in bronchial epithelial cells to promote apical junction assembly.
      Title: LKB1 controls human bronchial epithelial morphogenesis through p114RhoGEF-dependent RhoA activation.
    6. Stimulation of cortical myosin phosphorylation by p114RhoGEF drives cell migration and tumor cell invasion.
      Title: Stimulation of cortical myosin phosphorylation by p114RhoGEF drives cell migration and tumor cell invasion.
    7. In its regulation of the circumferential actomyosin tensile system, Lulu2 interacts with and activates p114RhoGEF at apical cell-cell junctions.
      Title: Lulu2 regulates the circumferential actomyosin tensile system in epithelial cells through p114RhoGEF.
    8. Data indicate that p114RhoGEF is a component of a junction-associated Rho signalling module that drives spatially restricted activation of RhoA to regulate junction formation and epithelial morphogenesis.
      Title: Spatially restricted activation of RhoA signalling at epithelial junctions by p114RhoGEF drives junction formation and morphogenesis.
    9. p114-RhoGEF and Lfc are critically involved in Wnt-3a- and Dvl-induced RhoA activation and neurite retraction in N1E-115 cells.
      Title: Involvement of p114-RhoGEF and Lfc in Wnt-3a- and dishevelled-induced RhoA activation and neurite retraction in N1E-115 mouse neuroblastoma cells.
    10. Observational study of gene-disease association. (HuGE Navigator)
      Title: Replication of previous genome-wide association studies of bone mineral density in premenopausal American women.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Retinitis pigmentosa 78
    MedGen: C4479481 OMIM: 617433 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    Genome-wide association study of SSRI/SNRI-induced sexual dysfunction in a Japanese cohort with major depression.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0521, MGC15913

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of stress fiber assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to cell-cell junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of cell shape IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within small GTPase-mediated signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell junction TAS
    Traceable Author Statement
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 18
    Names
    114 kDa Rho-specific guanine nucleotide exchange factor
    Rho-specific guanine nucleotide exchange factor p114
    Rho/Rac guanine nucleotide exchange factor (GEF) 18
    septin-associated RhoGEF

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047135.2 RefSeqGene

      Range
      5002..128543
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001130955.2 → NP_001124427.2  rho guanine nucleotide exchange factor 18 isoform b

      Status: REVIEWED

      Source sequence(s)
      AA609742, AB011093, AC008878, AK127045
      Consensus CDS
      CCDS45946.2
      UniProtKB/TrEMBL
      A0A087WZG4, A0A3B3IPE9
      Related
      ENSP00000352995.5, ENST00000359920.11

    2. NM_001367823.1 → NP_001354752.1  rho guanine nucleotide exchange factor 18 isoform c

      Status: REVIEWED

      Source sequence(s)
      AC008878, AC119396
      Consensus CDS
      CCDS92502.1
      UniProtKB/Swiss-Prot
      A8MV62, B5ME81, I3L1I5, O60274, Q6DD92, Q6ZSZ5
      Related
      ENSP00000499655.2, ENST00000668164.2

    3. NM_001367824.1 → NP_001354753.1  rho guanine nucleotide exchange factor 18 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC008878, AC119396
      Consensus CDS
      CCDS12177.1
      UniProtKB/TrEMBL
      A0A804CAZ4
      Related
      ENSP00000482647.4, ENST00000617428.4

    4. NM_015318.4 → NP_056133.2  rho guanine nucleotide exchange factor 18 isoform a

      See identical proteins and their annotated locations for NP_056133.2

      Status: REVIEWED

      Source sequence(s)
      AA609742, AB011093, AK127045, DB075637
      Consensus CDS
      CCDS12177.1
      UniProtKB/TrEMBL
      A0A804CAZ4
      Conserved Domains (5) summary
      cd00160
      Location:102 → 296
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd15794
      Location:336 → 454
      PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
      pfam00169
      Location:375 → 440
      PH; PH domain
      pfam11981
      Location:704 → 777
      DUF3482; Domain of unknown function (DUF3482)
      cl24005
      Location:650 → 745
      DUF2570; Protein of unknown function (DUF2570)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      7348937..7479989
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006722706.4 → XP_006722769.1  rho guanine nucleotide exchange factor 18 isoform X3

      See identical proteins and their annotated locations for XP_006722769.1

      UniProtKB/Swiss-Prot
      A8MV62, B5ME81, I3L1I5, O60274, Q6DD92, Q6ZSZ5
      Conserved Domains (4) summary
      PRK13729
      Location:1084 → 1228
      PRK13729; conjugal transfer pilus assembly protein TraB; Provisional
      cd00160
      Location:448 → 642
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd15794
      Location:682 → 800
      PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
      cl25742
      Location:1014 → 1128
      ERM; Ezrin/radixin/moesin family

    2. XM_011527836.3 → XP_011526138.1  rho guanine nucleotide exchange factor 18 isoform X1

      See identical proteins and their annotated locations for XP_011526138.1

      Conserved Domains (6) summary
      cd00160
      Location:513 → 707
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd15794
      Location:747 → 865
      PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
      pfam00169
      Location:786 → 851
      PH; PH domain
      pfam12474
      Location:1086 → 1193
      PKK; Polo kinase kinase
      pfam13863
      Location:1111 → 1190
      DUF4200; Domain of unknown function (DUF4200)
      cl24005
      Location:1061 → 1156
      DUF2570; Protein of unknown function (DUF2570)

    3. XM_011527837.3 → XP_011526139.1  rho guanine nucleotide exchange factor 18 isoform X2

      Conserved Domains (6) summary
      cd00160
      Location:513 → 707
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd15794
      Location:747 → 865
      PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
      pfam00169
      Location:786 → 851
      PH; PH domain
      pfam12474
      Location:1086 → 1193
      PKK; Polo kinase kinase
      pfam13863
      Location:1111 → 1190
      DUF4200; Domain of unknown function (DUF4200)
      cl24005
      Location:1061 → 1156
      DUF2570; Protein of unknown function (DUF2570)

    4. XM_005272464.5 → XP_005272521.1  rho guanine nucleotide exchange factor 18 isoform X1

      See identical proteins and their annotated locations for XP_005272521.1

      Conserved Domains (6) summary
      cd00160
      Location:513 → 707
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd15794
      Location:747 → 865
      PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
      pfam00169
      Location:786 → 851
      PH; PH domain
      pfam12474
      Location:1086 → 1193
      PKK; Polo kinase kinase
      pfam13863
      Location:1111 → 1190
      DUF4200; Domain of unknown function (DUF4200)
      cl24005
      Location:1061 → 1156
      DUF2570; Protein of unknown function (DUF2570)

    5. XM_011527841.3 → XP_011526143.1  rho guanine nucleotide exchange factor 18 isoform X7

      Conserved Domains (3) summary
      cd00160
      Location:513 → 707
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd15794
      Location:747 → 865
      PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
      pfam00169
      Location:786 → 851
      PH; PH domain

    6. XM_011527839.3 → XP_011526141.1  rho guanine nucleotide exchange factor 18 isoform X4

      UniProtKB/TrEMBL
      A0A590UK10
      Conserved Domains (5) summary
      cd00160
      Location:432 → 626
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd15794
      Location:666 → 784
      PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
      pfam00169
      Location:705 → 770
      PH; PH domain
      pfam13863
      Location:1030 → 1109
      DUF4200; Domain of unknown function (DUF4200)
      cl24005
      Location:980 → 1075
      DUF2570; Protein of unknown function (DUF2570)

    7. XM_047438526.1 → XP_047294482.1  rho guanine nucleotide exchange factor 18 isoform X5

    8. XM_047438527.1 → XP_047294483.1  rho guanine nucleotide exchange factor 18 isoform X6

    9. XM_047438528.1 → XP_047294484.1  rho guanine nucleotide exchange factor 18 isoform X5

    RNA

    1. XR_007066705.1 RNA Sequence

    2. XR_007066706.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      7341415..7480103
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320376.1 → XP_054176351.1  rho guanine nucleotide exchange factor 18 isoform X3

      UniProtKB/Swiss-Prot
      A8MV62, B5ME81, I3L1I5, O60274, Q6DD92, Q6ZSZ5

    2. XM_054320374.1 → XP_054176349.1  rho guanine nucleotide exchange factor 18 isoform X1

    3. XM_054320373.1 → XP_054176348.1  rho guanine nucleotide exchange factor 18 isoform X1

    4. XM_054320372.1 → XP_054176347.1  rho guanine nucleotide exchange factor 18 isoform X1

    5. XM_054320375.1 → XP_054176350.1  rho guanine nucleotide exchange factor 18 isoform X2

    6. XM_054320382.1 → XP_054176357.1  rho guanine nucleotide exchange factor 18 isoform X7

    7. XM_054320377.1 → XP_054176352.1  rho guanine nucleotide exchange factor 18 isoform X4

    8. XM_054320379.1 → XP_054176354.1  rho guanine nucleotide exchange factor 18 isoform X5

    9. XM_054320380.1 → XP_054176355.1  rho guanine nucleotide exchange factor 18 isoform X6

    10. XM_054320378.1 → XP_054176353.1  rho guanine nucleotide exchange factor 18 isoform X5

    11. XM_054320381.1 → XP_054176356.1  rho guanine nucleotide exchange factor 18 isoform X5

    RNA

    1. XR_008485127.1 RNA Sequence

    2. XR_008485128.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZSZ5.4 GenPept UniProtKB/Swiss-Prot:Q6ZSZ5

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