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    Insig1 insulin induced gene 1 [ Mus musculus (house mouse) ]

    Gene ID: 231070, updated on 5-Aug-2018

    Summary

    Official Symbol
    Insig1provided by MGI
    Official Full Name
    insulin induced gene 1provided by MGI
    Primary source
    MGI:MGI:1916289
    See related
    Ensembl:ENSMUSG00000045294 Vega:OTTMUSG00000042425
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Insig-1; 1810013C12Rik
    Expression
    Broad expression in liver adult (RPKM 186.8), adrenal adult (RPKM 174.3) and 26 other tissues See more
    Orthologs

    Genomic context

    See Insig1 in Genome Data Viewer
    Location:
    5; 5 B1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (28071412..28078662)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (28397952..28405202)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene microfibrillar-associated protein 1 pseudogene Neighboring gene predicted gene, 35223 Neighboring gene predicted gene, 26608 Neighboring gene predicted gene, 35055 Neighboring gene engrailed 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    SREBP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    SREBP-SCAP complex retention in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to sterol ISO
    Inferred from Sequence Orthology
    more info
     
    cholesterol biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cholesterol homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    cholesterol metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cranial suture morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    inner ear morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    middle ear morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of cargo loading into COPII-coated vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of fat cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of fatty acid biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of protein exit from endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of steroid biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to sterol depletion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    roof of mouth development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    steroid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    sterol biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    triglyceride metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    SREBP-SCAP-Insig complex ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum TAS
    Traceable Author Statement
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    insulin-induced gene 1 protein
    Names
    INSIG-1 membrane protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153526.5NP_705746.1  insulin-induced gene 1 protein

      See identical proteins and their annotated locations for NP_705746.1

      Status: VALIDATED

      Source sequence(s)
      AK151186, BC079559
      Consensus CDS
      CCDS19142.1
      UniProtKB/Swiss-Prot
      Q8BGI3
      Related
      ENSMUSP00000061877.10, OTTMUSP00000062703, ENSMUST00000059155.10, OTTMUST00000111854
      Conserved Domains (1) summary
      pfam07281
      Location:69249
      INSIG; Insulin-induced protein (INSIG)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      28071412..28078662
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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