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    Ptbp3 polypyrimidine tract binding protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 230257, updated on 29-Jun-2021

    Summary

    Official Symbol
    Ptbp3provided by MGI
    Official Full Name
    polypyrimidine tract binding protein 3provided by MGI
    Primary source
    MGI:MGI:1923334
    See related
    Ensembl:ENSMUSG00000028382
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ro; Rod1; C86549; AA407443; AI462022; AW107884; 5830471K22Rik
    Expression
    Ubiquitous expression in placenta adult (RPKM 36.2), liver E14 (RPKM 17.5) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ptbp3 in Genome Data Viewer
    Location:
    4; 4 B3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (59471868..59549376, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (59471868..59549378, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (59484740..59562236, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35578 Neighboring gene sushi domain containing 1 Neighboring gene zinc finger, MYND domain containing 19 pseudogene Neighboring gene RIKEN cDNA E130308A19 gene Neighboring gene hydroxysteroid dehydrogenase like 2 Neighboring gene predicted gene, 54283

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC11742

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within erythrocyte maturation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    polypyrimidine tract-binding protein 3
    Names
    ROD1 regulator of differentiation 1
    regulator of differentiation 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144904.2NP_659153.2  polypyrimidine tract-binding protein 3 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK033732, AL824704, BY119845, CJ101924, CJ103126
      Consensus CDS
      CCDS18220.2
      UniProtKB/Swiss-Prot
      Q8BHD7
      UniProtKB/TrEMBL
      G8JL74
      Related
      ENSMUSP00000099947.5, ENSMUST00000102883.11
      Conserved Domains (5) summary
      cd12693
      Location:178273
      RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12703
      Location:471551
      RRM4_ROD1; RNA recognition motif 4 in vertebrate regulator of differentiation 1 (Rod1)
      cd12779
      Location:53142
      RRM1_ROD1; RNA recognition motif 1 in vertebrate regulator of differentiation 1 (Rod1)
      TIGR01649
      Location:56551
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
      cl17169
      Location:358450
      RRM_SF; RNA recognition motif (RRM) superfamily
    2. NM_178164.3NP_835458.1  polypyrimidine tract-binding protein 3 isoform 2

      See identical proteins and their annotated locations for NP_835458.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in its 5' end which results in the use of an in-frame downstream start codon and also uses an alternate splice site in its 5' coding region, compared to variant 1. The encoded protein (isoform 2) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AK033732, AL824704, CJ101924
      Consensus CDS
      CCDS18221.1
      UniProtKB/Swiss-Prot
      Q8BHD7
      Related
      ENSMUSP00000030076.6, ENSMUST00000030076.12
      Conserved Domains (5) summary
      cd12693
      Location:150245
      RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12703
      Location:443523
      RRM4_ROD1; RNA recognition motif 4 in vertebrate regulator of differentiation 1 (Rod1)
      cd12779
      Location:25114
      RRM1_ROD1; RNA recognition motif 1 in vertebrate regulator of differentiation 1 (Rod1)
      TIGR01649
      Location:28523
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
      cl17169
      Location:330422
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      59471868..59549376 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006537851.4XP_006537914.1  polypyrimidine tract-binding protein 3 isoform X1

      Conserved Domains (1) summary
      TIGR01649
      Location:61556
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
    2. XM_006537854.5XP_006537917.1  polypyrimidine tract-binding protein 3 isoform X3

      See identical proteins and their annotated locations for XP_006537917.1

      UniProtKB/Swiss-Prot
      Q8BHD7
      Related
      ENSMUSP00000122840.3, ENSMUST00000148331.9
      Conserved Domains (1) summary
      TIGR01649
      Location:25520
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
    3. XM_006537852.5XP_006537915.1  polypyrimidine tract-binding protein 3 isoform X2

      UniProtKB/TrEMBL
      G3UXA6
      Related
      ENSMUSP00000133612.2, ENSMUST00000174586.8
      Conserved Domains (1) summary
      TIGR01649
      Location:59554
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
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