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    Gatad2b GATA zinc finger domain containing 2B [ Mus musculus (house mouse) ]

    Gene ID: 229542, updated on 23-Jun-2021

    Summary

    Official Symbol
    Gatad2bprovided by MGI
    Official Full Name
    GATA zinc finger domain containing 2Bprovided by MGI
    Primary source
    MGI:MGI:2443225
    See related
    Ensembl:ENSMUSG00000042390
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p66be; P66beta; AL118180; mKIAA1150; C430014D17Rik
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 10.2), CNS E14 (RPKM 8.9) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Gatad2b in Genome Data Viewer
    Location:
    3; 3 F1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (90200488..90270712)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (90293181..90363405)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (90145576..90162042)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene cAMP responsive element binding protein 3-like 4 Neighboring gene CREB regulated transcription coactivator 2 Neighboring gene DENN/MADD domain containing 4B Neighboring gene microRNA 7012 Neighboring gene solute carrier family 27 (fatty acid transporter), member 3 Neighboring gene integrator complex subunit 3 Neighboring gene natriuretic peptide receptor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA1150

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of NuRD complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    transcriptional repressor p66-beta
    Names
    GATA zinc finger domain-containing protein 2B
    p66/p68
    transcription repressor p66 beta component of the MeCP1 complex
    transcription repressor p66 component of the MeCP1 complex

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001379655.1NP_001366584.1  transcriptional repressor p66-beta isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1-3 all encode the same isoform (a).
      Source sequence(s)
      AC119825, AC145082
      Conserved Domains (2) summary
      pfam00320
      Location:421455
      GATA; GATA zinc finger
      pfam16563
      Location:161195
      P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
    2. NM_001379656.1NP_001366585.1  transcriptional repressor p66-beta isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3), as well as variants 1 and 2, encodes the longer isoform (a).
      Source sequence(s)
      AC119825, AC145082
      Related
      ENSMUSP00000142617.2, ENSMUST00000199607.5
      Conserved Domains (2) summary
      pfam00320
      Location:421455
      GATA; GATA zinc finger
      pfam16563
      Location:161195
      P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
    3. NM_001379657.1NP_001366586.1  transcriptional repressor p66-beta isoform b

      Status: VALIDATED

      Source sequence(s)
      AC119825, AC145082
      Conserved Domains (2) summary
      pfam00320
      Location:420454
      GATA; GATA zinc finger
      pfam16563
      Location:161195
      P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
    4. NM_139304.3NP_647465.1  transcriptional repressor p66-beta isoform a

      See identical proteins and their annotated locations for NP_647465.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2), as well as variants 1 and 3, encodes the longer isoform (a).
      Source sequence(s)
      AC119825, AC145082
      Consensus CDS
      CCDS17526.1
      UniProtKB/Swiss-Prot
      Q8VHR5
      Related
      ENSMUSP00000142514.2, ENSMUST00000199754.5
      Conserved Domains (2) summary
      pfam00320
      Location:421455
      GATA; GATA zinc finger
      pfam16563
      Location:161195
      P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      90200488..90270712
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501360.5XP_006501423.3  transcriptional repressor p66-beta isoform X2

      Conserved Domains (2) summary
      pfam00320
      Location:497530
      GATA; GATA zinc finger
      pfam16563
      Location:238272
      P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
    2. XM_006501359.5XP_006501422.3  transcriptional repressor p66-beta isoform X1

      Conserved Domains (2) summary
      pfam00320
      Location:498531
      GATA; GATA zinc finger
      pfam16563
      Location:238272
      P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
    3. XM_036163055.1XP_036018948.1  transcriptional repressor p66-beta isoform X3

      Conserved Domains (2) summary
      pfam00320
      Location:421455
      GATA; GATA zinc finger
      pfam16563
      Location:161195
      P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
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