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    Gatad2b GATA zinc finger domain containing 2B [ Mus musculus (house mouse) ]

    Gene ID: 229542, updated on 26-Sep-2022

    Summary

    Official Symbol
    Gatad2bprovided by MGI
    Official Full Name
    GATA zinc finger domain containing 2Bprovided by MGI
    Primary source
    MGI:MGI:2443225
    See related
    Ensembl:ENSMUSG00000042390 AllianceGenome:MGI:2443225
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P66beta; mKIAA1150; C430014D17Rik
    Summary
    Predicted to enable sequence-specific DNA binding activity and zinc ion binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be part of NuRD complex. Is expressed in early conceptus and genitourinary system. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 18. Orthologous to human GATAD2B (GATA zinc finger domain containing 2B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 10.2), CNS E14 (RPKM 8.9) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Gatad2b in Genome Data Viewer
    Location:
    3; 3 F1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (90200488..90270712)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (90293181..90363405)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene cAMP responsive element binding protein 3-like 4 Neighboring gene CREB regulated transcription coactivator 2 Neighboring gene DENN/MADD domain containing 4B Neighboring gene microRNA 7012 Neighboring gene solute carrier family 27 (fatty acid transporter), member 3 Neighboring gene integrator complex subunit 3 Neighboring gene natriuretic peptide receptor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA1150

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of NuRD complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of NuRD complex IC
    Inferred by Curator
    more info
    PubMed 
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    transcriptional repressor p66-beta
    Names
    GATA zinc finger domain-containing protein 2B
    p66/p68
    transcription repressor p66 beta component of the MeCP1 complex
    transcription repressor p66 component of the MeCP1 complex

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001379655.1NP_001366584.1  transcriptional repressor p66-beta isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1-3 all encode the same isoform (a).
      Source sequence(s)
      AC119825, AC145082
      UniProtKB/Swiss-Prot
      Q8C9Q3
      Conserved Domains (2) summary
      pfam00320
      Location:421455
      GATA; GATA zinc finger
      pfam16563
      Location:161195
      P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
    2. NM_001379656.1NP_001366585.1  transcriptional repressor p66-beta isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3), as well as variants 1 and 2, encodes the longer isoform (a).
      Source sequence(s)
      AC119825, AC145082
      UniProtKB/Swiss-Prot
      Q8C9Q3
      Related
      ENSMUSP00000142617.2, ENSMUST00000199607.5
      Conserved Domains (2) summary
      pfam00320
      Location:421455
      GATA; GATA zinc finger
      pfam16563
      Location:161195
      P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
    3. NM_001379657.1NP_001366586.1  transcriptional repressor p66-beta isoform b

      Status: VALIDATED

      Source sequence(s)
      AC119825, AC145082
      Conserved Domains (2) summary
      pfam00320
      Location:420454
      GATA; GATA zinc finger
      pfam16563
      Location:161195
      P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
    4. NM_139304.3NP_647465.1  transcriptional repressor p66-beta isoform a

      See identical proteins and their annotated locations for NP_647465.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2), as well as variants 1 and 3, encodes the longer isoform (a).
      Source sequence(s)
      AC119825, AC145082
      Consensus CDS
      CCDS17526.1
      UniProtKB/Swiss-Prot
      Q8C9Q3, Q8VHR5
      Related
      ENSMUSP00000142514.2, ENSMUST00000199754.5
      Conserved Domains (2) summary
      pfam00320
      Location:421455
      GATA; GATA zinc finger
      pfam16563
      Location:161195
      P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      90200488..90270712
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501360.5XP_006501423.3  transcriptional repressor p66-beta isoform X2

      Conserved Domains (2) summary
      pfam00320
      Location:497530
      GATA; GATA zinc finger
      pfam16563
      Location:238272
      P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
    2. XM_006501359.5XP_006501422.3  transcriptional repressor p66-beta isoform X1

      Conserved Domains (2) summary
      pfam00320
      Location:498531
      GATA; GATA zinc finger
      pfam16563
      Location:238272
      P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
    3. XM_036163055.1XP_036018948.1  transcriptional repressor p66-beta isoform X3

      UniProtKB/Swiss-Prot
      Q8C9Q3
      Conserved Domains (2) summary
      pfam00320
      Location:421455
      GATA; GATA zinc finger
      pfam16563
      Location:161195
      P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2