Format

Send to:

Choose Destination
    • Showing Current items.

    Cldnd1 claudin domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 224250, updated on 21-Aug-2021

    Summary

    Official Symbol
    Cldnd1provided by MGI
    Official Full Name
    claudin domain containing 1provided by MGI
    Primary source
    MGI:MGI:2447860
    See related
    Ensembl:ENSMUSG00000022744
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cldn; Cldn25; AA407103; AI849195; AW489850; claudin-25; 1110019C08Rik
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 32.2), CNS E18 (RPKM 29.1) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Cldnd1 in Genome Data Viewer
    Location:
    16; 16 C1.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (58548269..58554610)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (58727910..58734247)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (58728157..58734350)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene coproporphyrinogen oxidase Neighboring gene G protein-coupled receptor 15 Neighboring gene predicted gene, 26019 Neighboring gene olfactory receptor 172

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    claudin domain-containing protein 1
    Names
    claudin 25

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252450.1NP_001239379.1  claudin domain-containing protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate internal splice site and initiates translation at an upstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a longer and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC159200
      Conserved Domains (1) summary
      cl21598
      Location:40257
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
    2. NM_001252451.1NP_001239380.1  claudin domain-containing protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate internal splice site, lacks an exon in the 3' coding region and initiates translation at an upstream, in-frame start codon, compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC159200
      Conserved Domains (1) summary
      cl21598
      Location:150210
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
    3. NM_001356488.1NP_001343417.1  claudin domain-containing protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC159200
      Consensus CDS
      CCDS28234.1
      Conserved Domains (1) summary
      cl21598
      Location:17234
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
    4. NM_171826.3NP_741968.1  claudin domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_741968.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AV368951, BC055695, BY122667, CA750661
      Consensus CDS
      CCDS28234.1
      UniProtKB/Swiss-Prot
      Q9CQX5
      Related
      ENSMUSP00000125497.2, ENSMUST00000162057.8
      Conserved Domains (1) summary
      cl21598
      Location:17234
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    RNA

    1. NR_045517.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an internal exon compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK152722, AV368951, BY122667
    2. NR_045518.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks two internal exons compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AI048668, AV368951, BC055695, BY122667, CD560460

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      58548269..58554610
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245886.4XP_011244188.1  claudin domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011244188.1

      Conserved Domains (1) summary
      cl21598
      Location:127187
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
    Support Center