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    Top1 topoisomerase (DNA) I [ Mus musculus (house mouse) ]

    Gene ID: 21969, updated on 7-Aug-2018

    Summary

    Official Symbol
    Top1provided by MGI
    Official Full Name
    topoisomerase (DNA) Iprovided by MGI
    Primary source
    MGI:MGI:98788
    See related
    Ensembl:ENSMUSG00000070544 Vega:OTTMUSG00000001178
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Top-1; AI467334; D130064I21Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 28.9), adrenal adult (RPKM 26.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Top1 in Genome Data Viewer
    Location:
    2 H2; 2 80.96 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (160645897..160722764)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (160471633..160548500)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34980 Neighboring gene predicted gene 14221 Neighboring gene phospholipase C, gamma 1 Neighboring gene zinc fingers and homeoboxes 3 Neighboring gene predicted gene, 35129

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    DNA topoisomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    DNA topoisomerase type I activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA topoisomerase type I activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA topoisomerase type I activity ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II proximal promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    supercoiled DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    DNA topological change IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA topological change IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA topological change ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    circadian regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    embryonic cleavage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    rRNA transcription ISO
    Inferred from Sequence Orthology
    more info
     
    rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    DNA topoisomerase complex (ATP-hydrolyzing) ISO
    Inferred from Sequence Orthology
    more info
     
    P-body ISO
    Inferred from Sequence Orthology
    more info
     
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dense fibrillar component ISO
    Inferred from Sequence Orthology
    more info
     
    fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perikaryon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein-DNA complex ISO
    Inferred from Sequence Orthology
    more info
     
    replication fork protection complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    DNA topoisomerase 1
    Names
    DNA topoisomerase I
    NP_033434.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009408.2NP_033434.2  DNA topoisomerase 1

      See identical proteins and their annotated locations for NP_033434.2

      Status: VALIDATED

      Source sequence(s)
      AK145538, AK164061, AL590414, CF733054, CF734074, CN717304, CO425650, DV645012
      Consensus CDS
      CCDS16995.1
      UniProtKB/Swiss-Prot
      Q04750
      UniProtKB/TrEMBL
      Q3TPX7, Q3ULF5
      Related
      ENSMUSP00000105094.2, OTTMUSP00000001137, ENSMUST00000109468.2, OTTMUST00000002309
      Conserved Domains (4) summary
      smart00435
      Location:362739
      TOPEUc; DNA Topoisomerase I (eukaryota)
      pfam01028
      Location:434637
      Topoisom_I; Eukaryotic DNA topoisomerase I, catalytic core
      pfam02919
      Location:217431
      Topoisom_I_N; Eukaryotic DNA topoisomerase I, DNA binding fragment
      pfam14370
      Location:697765
      Topo_C_assoc; C-terminal topoisomerase domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      160645897..160722764
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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