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    Top1 topoisomerase (DNA) I [ Mus musculus (house mouse) ]

    Gene ID: 21969, updated on 23-Jun-2021

    Summary

    Official Symbol
    Top1provided by MGI
    Official Full Name
    topoisomerase (DNA) Iprovided by MGI
    Primary source
    MGI:MGI:98788
    See related
    Ensembl:ENSMUSG00000070544
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Top; Top-1; AI467334; D130064I21Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 28.9), adrenal adult (RPKM 26.1) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Top1 in Genome Data Viewer
    Location:
    2 H2; 2 80.96 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (160487817..160564684)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (160645897..160722764)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (160471633..160548500)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 14221 Neighboring gene uncharacterized LOC115489488 Neighboring gene predicted gene, 54128 Neighboring gene phospholipase C, gamma 1 Neighboring gene zinc fingers and homeoboxes 3 Neighboring gene predicted gene, 35129

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA topoisomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA topoisomerase type I (single strand cut, ATP-independent) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables DNA topoisomerase type I (single strand cut, ATP-independent) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA topoisomerase type I (single strand cut, ATP-independent) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables supercoiled DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in DNA topological change IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within DNA topological change IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in DNA topological change ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in circadian regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within embryonic cleavage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in rRNA transcription ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in P-body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dense fibrillar component ISO
    Inferred from Sequence Orthology
    more info
     
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perikaryon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-DNA complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DNA topoisomerase 1
    Names
    DNA topoisomerase I
    NP_033434.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009408.2NP_033434.2  DNA topoisomerase 1

      See identical proteins and their annotated locations for NP_033434.2

      Status: VALIDATED

      Source sequence(s)
      AK145538, AK164061, AL590414, CF733054, CF734074, CN717304, CO425650, DV645012
      Consensus CDS
      CCDS16995.1
      UniProtKB/Swiss-Prot
      Q04750
      UniProtKB/TrEMBL
      Q3TPX7, Q3ULF5
      Related
      ENSMUSP00000105094.3, ENSMUST00000109468.3
      Conserved Domains (4) summary
      smart00435
      Location:362739
      TOPEUc; DNA Topoisomerase I (eukaryota)
      pfam01028
      Location:434637
      Topoisom_I; Eukaryotic DNA topoisomerase I, catalytic core
      pfam02919
      Location:217431
      Topoisom_I_N; Eukaryotic DNA topoisomerase I, DNA binding fragment
      pfam14370
      Location:697765
      Topo_C_assoc; C-terminal topoisomerase domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      160487817..160564684
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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