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    Ccar2 cell cycle activator and apoptosis regulator 2 [ Mus musculus (house mouse) ]

    Gene ID: 219158, updated on 31-Jan-2019

    Summary

    Official Symbol
    Ccar2provided by MGI
    Official Full Name
    cell cycle activator and apoptosis regulator 2provided by MGI
    Primary source
    MGI:MGI:2444228
    See related
    Ensembl:ENSMUSG00000033712
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dbc1; mKIAA1967; 2610301G19Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 35.4), whole brain E14.5 (RPKM 35.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Ccar2 in Genome Data Viewer
    Location:
    14; 14 D2
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (70138168..70153814, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (70537975..70553598, complement)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene early growth response 3 Neighboring gene predicted gene, 41199 Neighboring gene bridging integrator 3 Neighboring gene RIKEN cDNA 9930012K11 gene Neighboring gene PDZ and LIM domain 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC7730

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA polymerase II complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA polymerase II complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enzyme inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear receptor transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA splicing ISO
    Inferred from Sequence Orthology
    more info
     
    Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial fragmentation involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of catalytic activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of catalytic activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of DNA damage checkpoint ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of DNA-templated transcription, elongation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of protein deacetylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to UV ISO
    Inferred from Sequence Orthology
    more info
     
    rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    DBIRD complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DBIRD complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cell cycle and apoptosis regulator protein 2
    Names
    cell division cycle and apoptosis regulator protein 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_146055.3NP_666167.3  cell cycle and apoptosis regulator protein 2

      See identical proteins and their annotated locations for NP_666167.3

      Status: VALIDATED

      Source sequence(s)
      AC151836
      Consensus CDS
      CCDS49534.1
      UniProtKB/Swiss-Prot
      Q8VDP4
      Related
      ENSMUSP00000036924.5, ENSMUST00000035612.6
      Conserved Domains (3) summary
      pfam13863
      Location:829908
      DUF4200; Domain of unknown function (DUF4200)
      pfam14443
      Location:343454
      DBC1; DBC1
      pfam14444
      Location:60112
      S1-like; S1-like

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

      Range
      70138168..70153814 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006518897.3XP_006518960.1  cell cycle and apoptosis regulator protein 2 isoform X2

      Conserved Domains (3) summary
      pfam13863
      Location:828907
      DUF4200; Domain of unknown function (DUF4200)
      pfam14443
      Location:343454
      DBC1; DBC1
      pfam14444
      Location:60112
      S1-like; S1-like
    2. XM_006518896.3XP_006518959.1  cell cycle and apoptosis regulator protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006518959.1

      UniProtKB/Swiss-Prot
      Q8VDP4
      Conserved Domains (3) summary
      pfam13863
      Location:829908
      DUF4200; Domain of unknown function (DUF4200)
      pfam14443
      Location:343454
      DBC1; DBC1
      pfam14444
      Location:60112
      S1-like; S1-like
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