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    Ccar2 cell cycle activator and apoptosis regulator 2 [ Mus musculus (house mouse) ]

    Gene ID: 219158, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ccar2provided by MGI
    Official Full Name
    cell cycle activator and apoptosis regulator 2provided by MGI
    Primary source
    MGI:MGI:2444228
    See related
    Ensembl:ENSMUSG00000033712
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dbc1; mKIAA1967; 2610301G19Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 35.4), whole brain E14.5 (RPKM 35.1) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ccar2 in Genome Data Viewer
    Location:
    14; 14 D2
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (70375617..70391272, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (70138168..70153791, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (70537975..70553598, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene early growth response 3 Neighboring gene bridging integrator 3 Neighboring gene RIKEN cDNA 9930012K11 gene Neighboring gene PDZ and LIM domain 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC7730

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables RNA polymerase II complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables enzyme inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear receptor coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in RNA splicing ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitochondrial fragmentation involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of catalytic activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of catalytic activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA damage checkpoint ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA-templated transcription, elongation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of protein deacetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription, DNA-templated IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in response to UV ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of DBIRD complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of DBIRD complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cell cycle and apoptosis regulator protein 2
    Names
    cell division cycle and apoptosis regulator protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_146055.3NP_666167.3  cell cycle and apoptosis regulator protein 2

      See identical proteins and their annotated locations for NP_666167.3

      Status: VALIDATED

      Source sequence(s)
      AC151836
      Consensus CDS
      CCDS49534.1
      UniProtKB/Swiss-Prot
      Q8VDP4
      Related
      ENSMUSP00000036924.6, ENSMUST00000035612.7
      Conserved Domains (4) summary
      COG1196
      Location:811917
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      PRK13914
      Location:444494
      PRK13914; invasion associated endopeptidase
      pfam14443
      Location:343454
      DBC1
      pfam14444
      Location:55112
      S1-like

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      70375617..70391272 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006518897.5XP_006518960.1  cell cycle and apoptosis regulator protein 2 isoform X2

      Conserved Domains (4) summary
      COG1196
      Location:810916
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      PRK13914
      Location:444494
      PRK13914; invasion associated endopeptidase
      pfam14443
      Location:343454
      DBC1
      pfam14444
      Location:55112
      S1-like
    2. XM_006518896.5XP_006518959.1  cell cycle and apoptosis regulator protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006518959.1

      UniProtKB/Swiss-Prot
      Q8VDP4
      Conserved Domains (4) summary
      COG1196
      Location:811917
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      PRK13914
      Location:444494
      PRK13914; invasion associated endopeptidase
      pfam14443
      Location:343454
      DBC1
      pfam14444
      Location:55112
      S1-like
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