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    Timm17a translocase of inner mitochondrial membrane 17a [ Mus musculus (house mouse) ]

    Gene ID: 21854, updated on 23-Jun-2021

    Summary

    Official Symbol
    Timm17aprovided by MGI
    Official Full Name
    translocase of inner mitochondrial membrane 17aprovided by MGI
    Primary source
    MGI:MGI:1343131
    See related
    Ensembl:ENSMUSG00000062580
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    17kD; mTim1; Tim17a; mTim17a
    Expression
    Ubiquitous expression in heart adult (RPKM 42.4), placenta adult (RPKM 34.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Timm17a in Genome Data Viewer
    Location:
    1; 1 E4
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (135229273..135241475, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (135301535..135313737, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (137198112..137210314, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene arginyl aminopeptidase (aminopeptidase B) Neighboring gene myeloma-overexpressed gene 2 protein homolog Neighboring gene predicted gene, 41956 Neighboring gene leiomodin 1 (smooth muscle)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to protein transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of protein processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein import into mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of TIM23 mitochondrial import inner membrane translocase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of TIM23 mitochondrial import inner membrane translocase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in integral component of mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    mitochondrial import inner membrane translocase subunit Tim17-A
    Names
    inner membrane preprotein translocase Tim17a
    translocator of inner mitochondrial membrane 17 kDa, a
    translocator of inner mitochondrial membrane 17a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360857.1NP_001347786.1  mitochondrial import inner membrane translocase subunit Tim17-A isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC130277
      Conserved Domains (1) summary
      cl02381
      Location:1149
      Tim17; Tim17/Tim22/Tim23/Pmp24 family
    2. NM_001360858.1NP_001347787.1  mitochondrial import inner membrane translocase subunit Tim17-A isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC130277
      Conserved Domains (1) summary
      cl02381
      Location:192
      Tim17; Tim17/Tim22/Tim23/Pmp24 family
    3. NM_011590.2NP_035720.1  mitochondrial import inner membrane translocase subunit Tim17-A isoform 2

      See identical proteins and their annotated locations for NP_035720.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AK003129
      Consensus CDS
      CCDS15318.1
      UniProtKB/Swiss-Prot
      Q9Z0V8
      UniProtKB/TrEMBL
      Q545U2
      Related
      ENSMUSP00000079883.4, ENSMUST00000081104.10
      Conserved Domains (1) summary
      TIGR00980
      Location:1171
      3a0801so1tim17; mitochondrial import inner membrane translocase subunit tim17

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      135229273..135241475 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001360856.1: Suppressed sequence

      Description
      NM_001360856.1: This RefSeq was removed because currently there is insufficient support for the transcript.
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