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    Ccdc28a coiled-coil domain containing 28A [ Mus musculus (house mouse) ]

    Gene ID: 215814, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ccdc28aprovided by MGI
    Official Full Name
    coiled-coil domain containing 28Aprovided by MGI
    Primary source
    MGI:MGI:2443508
    See related
    Ensembl:ENSMUSG00000059554 AllianceGenome:MGI:2443508
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700009P13Rik
    Summary
    Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and respiratory system. Orthologous to human CCDC28A (coiled-coil domain containing 28A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 26.8), cerebellum adult (RPKM 11.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ccdc28a in Genome Data Viewer
    Location:
    10 A3; 10 7.53 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (18089424..18110940, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (18213676..18235805, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_25888 Neighboring gene RalBP1 associated Eps domain containing protein Neighboring gene STARR-seq mESC enhancer starr_25889 Neighboring gene epithelial cell transforming sequence 2 oncogene-like Neighboring gene STARR-positive B cell enhancer ABC_E8992 Neighboring gene STARR-positive B cell enhancer mm9_chr10:17930879-17931180 Neighboring gene STARR-positive B cell enhancer ABC_E8325 Neighboring gene predicted gene 10827 Neighboring gene predicted gene, 53616 Neighboring gene NHS like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CCDC28A deficiency causes sperm head defects, reduced sperm motility and male infertility in mice. Zhou H, et al. Cell Mol Life Sci, 2024 Apr 10. PMID 38597936, Free PMC Article
    2. Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. Tamplin OJ, et al. BMC Genomics, 2008 Oct 30. PMID 18973680, Free PMC Article
    3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CCDC28A deficiency causes sperm head defects, reduced sperm motility and male infertility in mice.
      Title: CCDC28A deficiency causes sperm head defects, reduced sperm motility and male infertility in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2)  1 citation
    • Targeted (3) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC19351

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    coiled-coil domain-containing protein 28A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001346751.1 → NP_001333680.1  coiled-coil domain-containing protein 28A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC153562
      Consensus CDS
      CCDS87966.1
      UniProtKB/TrEMBL
      Q8CEI3
      Related
      ENSMUSP00000050107.9, ENSMUST00000052648.9

    2. NM_144820.4 → NP_659069.2  coiled-coil domain-containing protein 28A isoform 1

      See identical proteins and their annotated locations for NP_659069.2

      Status: VALIDATED

      Source sequence(s)
      AK148447, AW048156
      Consensus CDS
      CCDS35852.1
      UniProtKB/TrEMBL
      Q3UFK1
      Related
      ENSMUSP00000079671.7, ENSMUST00000080860.13
      Conserved Domains (1) summary
      pfam13270
      Location:83 → 167
      DUF4061; Domain of unknown function (DUF4061)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      18089424..18110940 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245002.2 → XP_030100862.1  coiled-coil domain-containing protein 28A isoform X1

      UniProtKB/TrEMBL
      G3UX80, G3UZ16
      Related
      ENSMUSP00000133585.2, ENSMUST00000173243.8
      Conserved Domains (1) summary
      pfam13270
      Location:29 → 114
      DUF4061; Domain of unknown function (DUF4061)

    RNA

    1. XR_003948656.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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