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    Slc6a6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6 [ Mus musculus (house mouse) ]

    Gene ID: 21366, updated on 26-Sep-2022

    Summary

    Official Symbol
    Slc6a6provided by MGI
    Official Full Name
    solute carrier family 6 (neurotransmitter transporter, taurine), member 6provided by MGI
    Primary source
    MGI:MGI:98488
    See related
    Ensembl:ENSMUSG00000030096 AllianceGenome:MGI:98488
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Taut
    Summary
    Enables beta-alanine transmembrane transporter activity and taurine transmembrane transporter activity. Involved in modulation of chemical synaptic transmission. Acts upstream of or within beta-alanine transport and taurine transport. Located in GABA-ergic synapse. Is integral component of postsynaptic membrane. Is expressed in several structures, including cardiovascular system; central nervous system; placenta; retina; and tooth. Used to study retinitis pigmentosa. Orthologous to human SLC6A6 (solute carrier family 6 member 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 68.2), kidney adult (RPKM 51.4) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Slc6a6 in Genome Data Viewer
    Location:
    6 D1; 6 40.73 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (91661031..91736044)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (91684048..91759063)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated Neighboring gene predicted gene, 40387 Neighboring gene predicted gene, 30628 Neighboring gene glutamate receptor interacting protein 2 Neighboring gene coiled-coil domain containing 174 Neighboring gene RIKEN cDNA 4930590J08 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2)  1 citation
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alanine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables amino acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables amino acid:sodium symporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables amino acid:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables beta-alanine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
     
    enables gamma-aminobutyric acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables gamma-aminobutyric acid:sodium:chloride symporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables gamma-aminobutyric acid:sodium:chloride symporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables taurine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables taurine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables taurine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables taurine:sodium symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables taurine:sodium symporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables taurine:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in alanine transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in amino acid import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within beta-alanine transport IDA
    Inferred from Direct Assay
    more info
     
    involved_in gamma-aminobutyric acid import ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in modulation of chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neurotransmitter transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neurotransmitter transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of nitrogen compound transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of positive regulation of cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of positive regulation of necrotic cell death ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in taurine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within taurine transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within taurine transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in taurine transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in GABA-ergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microvillus membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IC
    Inferred by Curator
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of plasma membrane protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    sodium- and chloride-dependent taurine transporter
    Names
    solute carrier family 6 member 6
    taurine/beta-alanine transporter

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410446.1NP_001397375.1  sodium- and chloride-dependent taurine transporter isoform a

      Status: VALIDATED

      Source sequence(s)
      AC162914
    2. NM_001410447.1NP_001397376.1  sodium- and chloride-dependent taurine transporter isoform a

      Status: VALIDATED

      Source sequence(s)
      AC162914
    3. NM_001410448.1NP_001397377.1  sodium- and chloride-dependent taurine transporter isoform b

      Status: VALIDATED

      Source sequence(s)
      AC162914
    4. NM_001410449.1NP_001397378.1  sodium- and chloride-dependent taurine transporter isoform c precursor

      Status: VALIDATED

      Source sequence(s)
      AC162914
    5. NM_001410450.1NP_001397379.1  sodium- and chloride-dependent taurine transporter isoform d precursor

      Status: VALIDATED

      Source sequence(s)
      AC162914
    6. NM_001410451.1NP_001397380.1  sodium- and chloride-dependent taurine transporter isoform e

      Status: VALIDATED

      Source sequence(s)
      AC162914
    7. NM_001410452.1NP_001397381.1  sodium- and chloride-dependent taurine transporter isoform e

      Status: VALIDATED

      Source sequence(s)
      AC162914
    8. NM_009320.5NP_033346.2  sodium- and chloride-dependent taurine transporter isoform a

      See identical proteins and their annotated locations for NP_033346.2

      Status: VALIDATED

      Source sequence(s)
      AC162914
      Consensus CDS
      CCDS39570.1
      UniProtKB/Swiss-Prot
      O35316, Q91WI2
      UniProtKB/TrEMBL
      A0A8C6GST5, Q3UPI8
      Related
      ENSMUSP00000032185.8, ENSMUST00000032185.9
      Conserved Domains (1) summary
      cl00456
      Location:41582
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RNA

    1. NR_177072.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC162914
    2. NR_177073.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC162914

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      91661031..91736044
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030255303.2XP_030111163.1  sodium- and chloride-dependent taurine transporter isoform X1

      UniProtKB/TrEMBL
      A0A8C6MTB7
      Conserved Domains (1) summary
      cl00456
      Location:51592
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    2. XM_006505871.4XP_006505934.1  sodium- and chloride-dependent taurine transporter isoform X2

      UniProtKB/Swiss-Prot
      O35316, Q91WI2
      UniProtKB/TrEMBL
      A0A8C6GST5, Q3UPI8
      Conserved Domains (1) summary
      cl00456
      Location:41582
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    3. XM_036166008.1XP_036021901.1  sodium- and chloride-dependent taurine transporter isoform X2

      UniProtKB/Swiss-Prot
      Q91WI2
      UniProtKB/TrEMBL
      A0A8C6GST5, Q3UPI8
      Conserved Domains (1) summary
      cl00456
      Location:41582
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    4. XM_030255304.2XP_030111164.1  sodium- and chloride-dependent taurine transporter isoform X2

      UniProtKB/Swiss-Prot
      Q91WI2
      UniProtKB/TrEMBL
      A0A8C6GST5, Q3UPI8
      Conserved Domains (1) summary
      cl00456
      Location:41582
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    5. XM_006505870.2XP_006505933.1  sodium- and chloride-dependent taurine transporter isoform X2

      See identical proteins and their annotated locations for XP_006505933.1

      UniProtKB/Swiss-Prot
      O35316, Q91WI2
      UniProtKB/TrEMBL
      A0A8C6GST5, Q3UPI8
      Conserved Domains (1) summary
      cl00456
      Location:41582
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    6. XM_036166010.1XP_036021903.1  sodium- and chloride-dependent taurine transporter isoform X2

      UniProtKB/Swiss-Prot
      Q91WI2
      UniProtKB/TrEMBL
      A0A8C6GST5, Q3UPI8
      Conserved Domains (1) summary
      cl00456
      Location:41582
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RNA

    1. XR_003956177.2 RNA Sequence

    2. XR_003956178.2 RNA Sequence