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    Cenpx centromere protein X [ Mus musculus (house mouse) ]

    Gene ID: 20892, updated on 23-Jun-2021

    Summary

    Official Symbol
    Cenpxprovided by MGI
    Official Full Name
    centromere protein Xprovided by MGI
    Primary source
    MGI:MGI:894324
    See related
    Ensembl:ENSMUSG00000025144
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Str; Stra13
    Expression
    Ubiquitous expression in kidney adult (RPKM 16.5), adrenal adult (RPKM 12.0) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Cenpx in Genome Data Viewer
    Location:
    11; 11 E2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (120601767..120604721, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120710941..120713895, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (120572255..120575081, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene notum palmitoleoyl-protein carboxylesterase Neighboring gene alveolar soft part sarcoma chromosome region, candidate 1 (human) Neighboring gene leucine rich repeat containing 45 Neighboring gene Rac family small GTPase 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in kinetochore assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in replication fork processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in replication fork processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in resolution of meiotic recombination intermediates IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in resolution of meiotic recombination intermediates ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of FANCM-MHF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of FANCM-MHF complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Fanconi anaemia nuclear complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of Fanconi anaemia nuclear complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    centromere protein X
    Names
    CENP-X
    FANCM-interacting histone fold protein 2
    Fanconi anemia-associated polypeptide of 10 kDa
    immediate-early-response protein D9
    retinoic acid-inducible gene D9 protein
    stimulated by retinoic acid 13
    stimulated by retinoic acid gene 13 protein homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347611.1NP_001334540.1  centromere protein X isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK076181, AL663030, CA320983, DV040265
      Consensus CDS
      CCDS83948.1
      UniProtKB/Swiss-Prot
      Q8C4X1
      Related
      ENSMUSP00000026137.8, ENSMUST00000026137.8
    2. NM_001347612.1NP_001334541.1  centromere protein X isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL663030, BC052335, CA320983
      Consensus CDS
      CCDS83947.1
      UniProtKB/TrEMBL
      A2AC07
      Related
      ENSMUSP00000101760.2, ENSMUST00000106154.8
      Conserved Domains (1) summary
      pfam09415
      Location:46113
      CENP-X; CENP-S associating Centromere protein X
    3. NM_016665.2NP_057874.2  centromere protein X isoform 1

      See identical proteins and their annotated locations for NP_057874.2

      Status: VALIDATED

      Source sequence(s)
      AK080500, CA320983, CJ236047
      Consensus CDS
      CCDS49009.1
      UniProtKB/Swiss-Prot
      Q8C4X1
      Related
      ENSMUSP00000050335.7, ENSMUST00000055424.13
      Conserved Domains (1) summary
      pfam09415
      Location:977
      CENP-X; CENP-S associating Centromere protein X

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      120601767..120604721 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248853.3XP_011247155.2  centromere protein X isoform X6

      Conserved Domains (1) summary
      pfam09415
      Location:89122
      CENP-X; CENP-S associating Centromere protein X
    2. XM_011248850.3XP_011247152.2  centromere protein X isoform X3

    3. XM_006532729.3XP_006532792.3  centromere protein X isoform X5

    4. XM_011248852.3XP_011247154.2  centromere protein X isoform X2

    5. XM_011248851.2XP_011247153.1  centromere protein X isoform X4

      Conserved Domains (1) summary
      pfam09415
      Location:943
      CENP-X; CENP-S associating Centromere protein X
    6. XM_011248849.3XP_011247151.1  centromere protein X isoform X1

      See identical proteins and their annotated locations for XP_011247151.1

      Conserved Domains (1) summary
      pfam09415
      Location:4679
      CENP-X; CENP-S associating Centromere protein X
    7. XM_036156492.1XP_036012385.1  centromere protein X isoform X7

      Conserved Domains (1) summary
      pfam09415
      Location:46113
      CENP-X; CENP-S associating Centromere protein X
    8. XM_011248848.1XP_011247150.1  centromere protein X isoform X1

      See identical proteins and their annotated locations for XP_011247150.1

      Conserved Domains (1) summary
      pfam09415
      Location:4679
      CENP-X; CENP-S associating Centromere protein X
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