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    Spint2 serine protease inhibitor, Kunitz type 2 [ Mus musculus (house mouse) ]

    Gene ID: 20733, updated on 7-Aug-2018

    Summary

    Official Symbol
    Spint2provided by MGI
    Official Full Name
    serine protease inhibitor, Kunitz type 2provided by MGI
    Primary source
    MGI:MGI:1338031
    See related
    Ensembl:ENSMUSG00000074227 Vega:OTTMUSG00000059216
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HAI-2; C76321; AL024025
    Expression
    Biased expression in colon adult (RPKM 448.1), duodenum adult (RPKM 435.7) and 13 other tissues See more
    Orthologs

    Genomic context

    See Spint2 in Genome Data Viewer
    Location:
    7; 7 B1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (29256330..29282066, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (30041349..30066996, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene potassium inwardly-rectifying channel, subfamily K, member 6 Neighboring gene Yip1 interacting factor homolog B (S. cerevisiae) Neighboring gene RIKEN cDNA 2200002D01 gene Neighboring gene predicted gene, 45977 Neighboring gene protein phosphatase 1, regulatory inhibitor subunit 14A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    peptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    serine-type endopeptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    basement membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epithelial cell morphogenesis involved in placental branching IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    epithelial cell morphogenesis involved in placental branching IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment or maintenance of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell motility ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neural precursor cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    neural tube closure IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neural tube closure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    kunitz-type protease inhibitor 2
    Names
    hepatocyte growth factor activator inhibitor type 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001082548.1NP_001076017.1  kunitz-type protease inhibitor 2 isoform b precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon, in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.
      Source sequence(s)
      AI227451, AK007792, BQ174562, CB196296
      Consensus CDS
      CCDS39869.1
      UniProtKB/Swiss-Prot
      Q9WU03
      UniProtKB/TrEMBL
      Q9D8Q8
      Related
      ENSMUSP00000103871.3, OTTMUSP00000075725, ENSMUST00000108236.4, OTTMUST00000145320
      Conserved Domains (1) summary
      cd00109
      Location:80126
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    2. NM_011464.2NP_035594.1  kunitz-type protease inhibitor 2 isoform a precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AI227451, AK007792, BQ174562, CB196296
      Consensus CDS
      CCDS39870.1
      UniProtKB/Swiss-Prot
      Q9WU03
      UniProtKB/TrEMBL
      Q9D8Q8
      Related
      ENSMUSP00000096204.4, OTTMUSP00000075726, ENSMUST00000098604.11, OTTMUST00000145321
      Conserved Domains (2) summary
      cd00109
      Location:137183
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:3888
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      29256330..29282066 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017322072.1XP_017177561.1  kunitz-type protease inhibitor 2 isoform X1

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