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    Rfc2 replication factor C (activator 1) 2 [ Mus musculus (house mouse) ]

    Gene ID: 19718, updated on 23-Jun-2021

    Summary

    Official Symbol
    Rfc2provided by MGI
    Official Full Name
    replication factor C (activator 1) 2provided by MGI
    Primary source
    MGI:MGI:1341868
    See related
    Ensembl:ENSMUSG00000023104
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    40kD; Recc; 40kDa; Recc2; AI326953; 2610008M13Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 104.6), liver E14 (RPKM 51.0) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Rfc2 in Genome Data Viewer
    Location:
    5 G2; 5 74.68 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (134611544..134627182)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (134582690..134598328)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (135058560..135074198)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene CAP-GLY domain containing linker protein 2 Neighboring gene syncytin a Neighboring gene microRNA 7228 Neighboring gene linker for activation of T cells family, member 2 Neighboring gene eukaryotic translation initiation factor 4H

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC117486

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to DNA clamp loader activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to DNA clamp loader activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to single-stranded DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA-dependent DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of DNA-directed DNA polymerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of Ctf18 RFC-like complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of DNA replication factor C complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of DNA replication factor C complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    replication factor C subunit 2
    Names
    A1 40 kDa subunit
    RF-C 40 kDa subunit
    RFC40
    activator 1 40 kDa subunit
    activator 1 subunit 2
    replication factor C 40 kDa subunit
    replication factor C, 40 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020022.2NP_064406.1  replication factor C subunit 2

      See identical proteins and their annotated locations for NP_064406.1

      Status: VALIDATED

      Source sequence(s)
      AK075997, BY338186
      Consensus CDS
      CCDS19722.1
      UniProtKB/Swiss-Prot
      Q9WUK4
      UniProtKB/TrEMBL
      Q4KL82
      Related
      ENSMUSP00000023867.7, ENSMUST00000023867.8
      Conserved Domains (4) summary
      cd00009
      Location:46180
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      PLN03025
      Location:31343
      PLN03025; replication factor C subunit; Provisional
      pfam08542
      Location:269337
      Rep_fac_C; Replication factor C C-terminal domain
      pfam16193
      Location:203231
      AAA_assoc_2; AAA C-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      134611544..134627182
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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