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    Pafah1b2 platelet-activating factor acetylhydrolase, isoform 1b, subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 18475, updated on 23-Jun-2021

    Summary

    Official Symbol
    Pafah1b2provided by MGI
    Official Full Name
    platelet-activating factor acetylhydrolase, isoform 1b, subunit 2provided by MGI
    Primary source
    MGI:MGI:108415
    See related
    Ensembl:ENSMUSG00000003131
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Paf; mus[b; Pafahb; mus[b]; AI747451; AU021353; 2610005M20R; 2610005M20Rik
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 37.3), CNS E18 (RPKM 36.5) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pafah1b2 in Genome Data Viewer
    Location:
    9; 9 A5.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (45876609..45923988, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (45965311..46012690, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (45773394..45792954, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A830035O19 gene Neighboring gene microRNA 7087 Neighboring gene SID1 transmembrane family, member 2 Neighboring gene predicted gene, 46110 Neighboring gene SIK family kinase 3 Neighboring gene POU domain, class 5, transcription factor 1, related sequence 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1-alkyl-2-acetylglycerophosphocholine esterase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables platelet-activating factor acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables platelet-activating factor acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in brain development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of macroautophagy ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within spermatogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of 1-alkyl-2-acetylglycerophosphocholine esterase complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    platelet-activating factor acetylhydrolase IB subunit alpha2; platelet-activating factor acetylhydrolase IB subunit beta
    Names
    PAF acetylhydrolase 30 kDa subunit
    PAF-AH 30 kDa subunit
    PAF-AH subunit beta
    NP_001344167.1
    NP_001344168.1
    NP_001344169.1
    NP_001344170.1
    NP_001344172.1
    NP_001344173.1
    NP_001344174.1
    NP_001344175.1
    NP_032801.2
    XP_030099983.1
    XP_030099984.1
    XP_036010577.1
    XP_036010578.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357238.1NP_001344167.1  platelet-activating factor acetylhydrolase IB subunit alpha2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC122273
      Conserved Domains (1) summary
      cd01820
      Location:21230
      PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...
    2. NM_001357239.1NP_001344168.1  platelet-activating factor acetylhydrolase IB subunit alpha2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AC122273
      Conserved Domains (1) summary
      cd01820
      Location:16225
      PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...
    3. NM_001357240.1NP_001344169.1  platelet-activating factor acetylhydrolase IB subunit alpha2 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AC122273
      Conserved Domains (1) summary
      cd01820
      Location:11220
      PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...
    4. NM_001357241.1NP_001344170.1  platelet-activating factor acetylhydrolase IB subunit alpha2 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4-8 all encode the same isoform (d).
      Source sequence(s)
      AC122273, BY293328, CA328016
      Consensus CDS
      CCDS23139.1
      Conserved Domains (1) summary
      cd01820
      Location:8217
      PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...
    5. NM_001357243.1NP_001344172.1  platelet-activating factor acetylhydrolase IB subunit alpha2 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4-8 all encode the same isoform (d).
      Source sequence(s)
      AC122273, CA328016
      Consensus CDS
      CCDS23139.1
      Related
      ENSMUSP00000151196.2, ENSMUST00000215060.2
      Conserved Domains (1) summary
      cd01820
      Location:8217
      PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...
    6. NM_001357244.1NP_001344173.1  platelet-activating factor acetylhydrolase IB subunit alpha2 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4-8 all encode the same isoform (d).
      Source sequence(s)
      AC122273
      Consensus CDS
      CCDS23139.1
      Conserved Domains (1) summary
      cd01820
      Location:8217
      PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...
    7. NM_001357245.1NP_001344174.1  platelet-activating factor acetylhydrolase IB subunit alpha2 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4-8 all encode the same isoform (d).
      Source sequence(s)
      AC122273
      Consensus CDS
      CCDS23139.1
      Conserved Domains (1) summary
      cd01820
      Location:8217
      PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...
    8. NM_001357246.1NP_001344175.1  platelet-activating factor acetylhydrolase IB subunit alpha2 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (e) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform a.
      Source sequence(s)
      AC122273, BY242419
      Conserved Domains (1) summary
      cd01820
      Location:8178
      PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...
    9. NM_008775.3NP_032801.2  platelet-activating factor acetylhydrolase IB subunit alpha2 isoform d

      See identical proteins and their annotated locations for NP_032801.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4-8 all encode the same isoform (d).
      Source sequence(s)
      AC122273, BB856076, BC056211
      Consensus CDS
      CCDS23139.1
      UniProtKB/Swiss-Prot
      Q61206
      Related
      ENSMUSP00000127851.2, ENSMUST00000172450.3
      Conserved Domains (1) summary
      cd01820
      Location:8217
      PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      45876609..45923988 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154685.1XP_036010578.1  platelet-activating factor acetylhydrolase IB subunit beta isoform X2

      Conserved Domains (1) summary
      cd01820
      Location:11220
      PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...
    2. XM_030244123.2XP_030099983.1  platelet-activating factor acetylhydrolase IB subunit beta isoform X1

      Conserved Domains (1) summary
      cd01820
      Location:16225
      PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...
    3. XM_036154684.1XP_036010577.1  platelet-activating factor acetylhydrolase IB subunit beta isoform X1

      Conserved Domains (1) summary
      cd01820
      Location:16225
      PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...
    4. XM_030244124.2XP_030099984.1  platelet-activating factor acetylhydrolase IB subunit beta isoform X2

      Conserved Domains (1) summary
      cd01820
      Location:11220
      PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...
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