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    Mest mesoderm specific transcript [ Mus musculus (house mouse) ]

    Gene ID: 17294, updated on 10-Aug-2021

    Summary

    Official Symbol
    Mestprovided by MGI
    Official Full Name
    mesoderm specific transcriptprovided by MGI
    Primary source
    MGI:MGI:96968
    See related
    Ensembl:ENSMUSG00000051855
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Peg; Peg1; AA408879; AI256745
    Expression
    Biased expression in limb E14.5 (RPKM 597.0), CNS E11.5 (RPKM 207.7) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Mest in Genome Data Viewer
    Location:
    6 A3.3; 6 12.53 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (30733505..30783580)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (30733506..30748466)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (30688063..30698457)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene carboxypeptidase A1, pancreatic Neighboring gene centrosomal protein 41 Neighboring gene predicted gene 13782 Neighboring gene microRNA 335 Neighboring gene coatomer protein complex, subunit gamma 2 Neighboring gene coatomer protein complex, subunit gamma 2, opposite strand 2 Neighboring gene RIKEN cDNA 4930412F09 gene Neighboring gene predicted gene, 38781 Neighboring gene testis specific gene A13

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in regulation of lipid storage IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to retinoic acid IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    mesoderm-specific transcript protein
    Names
    paternally-expressed gene 1 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252292.1NP_001239221.1  mesoderm-specific transcript protein isoform 1

      See identical proteins and their annotated locations for NP_001239221.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).
      Source sequence(s)
      AK146457, AK168732, AK169266, BF608470
      Consensus CDS
      CCDS80512.1
      UniProtKB/Swiss-Prot
      Q07646
      UniProtKB/TrEMBL
      D3Z383
      Related
      ENSMUSP00000117713.3, ENSMUST00000124665.3
      Conserved Domains (1) summary
      COG0596
      Location:54328
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    2. NM_001252293.1NP_001239222.1  mesoderm-specific transcript protein isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has a different 5' end, compared to variant 1. The resulting protein (isoform 3) has a shorter N-terminus when it is compared to isoform 1.
      Source sequence(s)
      AF482999, AK146457, BF608470, CF916557
      Consensus CDS
      CCDS80513.1
      UniProtKB/Swiss-Prot
      Q07646
      Related
      ENSMUSP00000119038.3, ENSMUST00000157040.8
      Conserved Domains (1) summary
      COG0596
      Location:38312
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    3. NM_008590.2NP_032616.1  mesoderm-specific transcript protein isoform 2

      See identical proteins and their annotated locations for NP_032616.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AK032881, BF608470, CJ162886
      Consensus CDS
      CCDS19979.1
      UniProtKB/Swiss-Prot
      Q07646
      Related
      ENSMUSP00000129639.3, ENSMUST00000163949.9
      Conserved Domains (1) summary
      COG0596
      Location:47321
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      30733505..30783580
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165900.1XP_036021793.1  mesoderm-specific transcript protein isoform X2

      Conserved Domains (1) summary
      COG0596
      Location:47321
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    2. XM_036165902.1XP_036021795.1  mesoderm-specific transcript protein isoform X4

      Conserved Domains (1) summary
      COG0596
      Location:47295
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    3. XM_036165901.1XP_036021794.1  mesoderm-specific transcript protein isoform X3

      Conserved Domains (1) summary
      COG0596
      Location:54302
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    4. XM_036165899.1XP_036021792.1  mesoderm-specific transcript protein isoform X1

      Conserved Domains (1) summary
      COG0596
      Location:54328
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
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