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    S100Z S100 calcium binding protein Z [ Homo sapiens (human) ]

    Gene ID: 170591, updated on 17-Jun-2024

    Summary

    Official Symbol
    S100Zprovided by HGNC
    Official Full Name
    S100 calcium binding protein Zprovided by HGNC
    Primary source
    HGNC:HGNC:30367
    See related
    Ensembl:ENSG00000171643 MIM:610103; AllianceGenome:HGNC:30367
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Gm625; S100-zeta
    Summary
    Members of the S100 protein family contain 2 calcium-binding EF-hands and exhibit cell-type specific expression patterns. For additional background information on S100 proteins, see MIM 114085.[supplied by OMIM, Mar 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See S100Z in Genome Data Viewer
    Location:
    5q13.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (76850014..76952953)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (77331819..77434785)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (76145839..76217475)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:76114571-76115188 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:76115189-76115806 Neighboring gene F2R like trypsin receptor 1 Neighboring gene RNA, 7SL, cytoplasmic 208, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22698 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:76166173-76166870 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:76184471-76184971 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:76221500-76221673 Neighboring gene RNA, U6atac small nuclear 36, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:76249596-76250282 Neighboring gene corticotropin releasing hormone binding protein Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:76325887-76326466 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:76326467-76327046 Neighboring gene angiogenic factor with G-patch and FHA domains 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     

    General protein information

    Preferred Names
    protein S100-Z
    Names
    S100 calcium binding protein, zeta

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130772.4NP_570128.2  protein S100-Z

      See identical proteins and their annotated locations for NP_570128.2

      Status: VALIDATED

      Source sequence(s)
      AC027342, AF437876, BC022320, BX281742, CD368348
      Consensus CDS
      CCDS43333.1
      UniProtKB/Swiss-Prot
      Q8WXG8
      Related
      ENSP00000320430.4, ENST00000317593.9
      Conserved Domains (1) summary
      cl08302
      Location:193
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      76850014..76952953
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011543241.3XP_011541543.1  protein S100-Z isoform X1

      See identical proteins and their annotated locations for XP_011541543.1

      UniProtKB/Swiss-Prot
      Q8WXG8
      Conserved Domains (1) summary
      cl08302
      Location:193
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    2. XM_011543240.4XP_011541542.1  protein S100-Z isoform X1

      See identical proteins and their annotated locations for XP_011541542.1

      UniProtKB/Swiss-Prot
      Q8WXG8
      Conserved Domains (1) summary
      cl08302
      Location:193
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    3. XM_011543244.3XP_011541546.1  protein S100-Z isoform X1

      See identical proteins and their annotated locations for XP_011541546.1

      UniProtKB/Swiss-Prot
      Q8WXG8
      Conserved Domains (1) summary
      cl08302
      Location:193
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    4. XM_047416869.1XP_047272825.1  protein S100-Z isoform X1

      UniProtKB/Swiss-Prot
      Q8WXG8
      Related
      ENSP00000426768.1, ENST00000513010.5
    5. XM_017009171.2XP_016864660.1  protein S100-Z isoform X1

      UniProtKB/Swiss-Prot
      Q8WXG8
      Conserved Domains (1) summary
      cl08302
      Location:193
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    6. XM_011543245.3XP_011541547.1  protein S100-Z isoform X1

      See identical proteins and their annotated locations for XP_011541547.1

      UniProtKB/Swiss-Prot
      Q8WXG8
      Conserved Domains (1) summary
      cl08302
      Location:193
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    7. XM_047416873.1XP_047272829.1  protein S100-Z isoform X1

      UniProtKB/Swiss-Prot
      Q8WXG8
    8. XM_047416872.1XP_047272828.1  protein S100-Z isoform X1

      UniProtKB/Swiss-Prot
      Q8WXG8
    9. XM_047416871.1XP_047272827.1  protein S100-Z isoform X1

      UniProtKB/Swiss-Prot
      Q8WXG8
      Related
      ENSP00000483535.1, ENST00000613039.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      77331819..77434785
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054351921.1XP_054207896.1  protein S100-Z isoform X1

      UniProtKB/Swiss-Prot
      Q8WXG8
    2. XM_054351922.1XP_054207897.1  protein S100-Z isoform X1

      UniProtKB/Swiss-Prot
      Q8WXG8
    3. XM_054351918.1XP_054207893.1  protein S100-Z isoform X1

      UniProtKB/Swiss-Prot
      Q8WXG8
    4. XM_054351923.1XP_054207898.1  protein S100-Z isoform X1

      UniProtKB/Swiss-Prot
      Q8WXG8
    5. XM_054351920.1XP_054207895.1  protein S100-Z isoform X1

      UniProtKB/Swiss-Prot
      Q8WXG8
    6. XM_054351919.1XP_054207894.1  protein S100-Z isoform X1

      UniProtKB/Swiss-Prot
      Q8WXG8

    RNA

    1. XR_008487091.1 RNA Sequence