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    TDRP testis development related protein [ Homo sapiens (human) ]

    Gene ID: 157695, updated on 5-Mar-2024

    Summary

    Official Symbol
    TDRPprovided by HGNC
    Official Full Name
    testis development related proteinprovided by HGNC
    Primary source
    HGNC:HGNC:26951
    See related
    Ensembl:ENSG00000180190 MIM:619049; AllianceGenome:HGNC:26951
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Inm01; TDRP1; TDRP2; C8orf42
    Summary
    Acts upstream of or within spermatogenesis. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in placenta (RPKM 17.5), thyroid (RPKM 13.8) and 22 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TDRP in Genome Data Viewer
    Location:
    8p23.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (489946..545780, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (249159..342875, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (439946..495780, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:328556-329056 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26942 Neighboring gene family with sequence similarity 87 member A Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18878 Neighboring gene F-box protein 25 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr8:429047-429548 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr8:429549-430048 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:436623-437436 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:437437-438248 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:452724-453298 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:482877-483378 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:486704-487214 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:487215-487724 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:495813-496313 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:527413-527914 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:527915-528414 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:563312-563864 Neighboring gene uncharacterized LOC124902055 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:579043-579586 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:580473-581672 Neighboring gene glutamate rich 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:601645-602146 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:602147-602646 Neighboring gene uncharacterized LOC124902053

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Mayo Genome Consortia: a genotype-phenotype resource for genome-wide association studies with an application to the analysis of circulating bilirubin levels.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ44221, DKFZp686J15216

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in spermatogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within spermatogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    testis development-related protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256113.2NP_001243042.1  testis development-related protein isoform 2

      See identical proteins and their annotated locations for NP_001243042.1

      Status: VALIDATED

      Source sequence(s)
      AC083964, AC090135
      Consensus CDS
      CCDS59090.1
      UniProtKB/Swiss-Prot
      Q86YL5
      Related
      ENSP00000430325.1, ENST00000523656.5
      Conserved Domains (1) summary
      pfam15683
      Location:41167
      TDRP; Testis development-related protein
    2. NM_001384899.1NP_001371828.1  testis development-related protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC083964, AC090135
      Consensus CDS
      CCDS47759.1
      UniProtKB/Swiss-Prot
      B6VF03, B9EG53, Q86YL5
      Related
      ENSP00000315111.6, ENST00000324079.11
      Conserved Domains (1) summary
      pfam15683
      Location:41185
      TDRP; Testis development-related protein
    3. NM_175075.5NP_778250.2  testis development-related protein isoform 1

      See identical proteins and their annotated locations for NP_778250.2

      Status: VALIDATED

      Source sequence(s)
      AC083964, AC090135, AC090691
      Consensus CDS
      CCDS47759.1
      UniProtKB/Swiss-Prot
      B6VF03, B9EG53, Q86YL5
      Conserved Domains (1) summary
      pfam15683
      Location:41185
      TDRP; Testis development-related protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      489946..545780 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047421392.1XP_047277348.1  testis development-related protein isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      249159..342875 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054359820.1XP_054215795.1  testis development-related protein isoform X7

    2. XM_054359818.1XP_054215793.1  testis development-related protein isoform X5

    3. XM_054359816.1XP_054215791.1  testis development-related protein isoform X3

    4. XM_054359814.1XP_054215789.1  testis development-related protein isoform X2

    5. XM_054359815.1XP_054215790.1  testis development-related protein isoform X2

    6. XM_054359817.1XP_054215792.1  testis development-related protein isoform X4

    7. XM_054359821.1XP_054215796.1  testis development-related protein isoform X8

    8. XM_054359819.1XP_054215794.1  testis development-related protein isoform X6

    RNA

    1. XR_008487813.1 RNA Sequence

    2. XR_008487814.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001369716.1: Suppressed sequence

      Description
      NM_001369716.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.