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    Nr6a1 nuclear receptor subfamily 6, group A, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 14536, updated on 23-Jun-2021

    Summary

    Official Symbol
    Nr6a1provided by MGI
    Official Full Name
    nuclear receptor subfamily 6, group A, member 1provided by MGI
    Primary source
    MGI:MGI:1352459
    See related
    Ensembl:ENSMUSG00000063972
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NC; Gcn; RTR; Gcnf; NCNF; 1700113M01Rik
    Expression
    Biased expression in testis adult (RPKM 28.1), placenta adult (RPKM 4.6) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Nr6a1 in Genome Data Viewer
    Location:
    2; 2 B
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (38613381..38816473, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (38723369..38926461, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (38578894..38781981, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene Nr5a1 enhancer in intron 4 Neighboring gene Nr5a1 5' regulatory region Neighboring gene nuclear receptor subfamily 5, group A, member 1 Neighboring gene nuclear receptor subfamily 6, group A, member 1, opposite strand Neighboring gene microRNA 181a-2 Neighboring gene microRNA 181b-2 Neighboring gene olfactomedin-like 2A Neighboring gene golgi autoantigen, golgin subfamily a,2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    nuclear receptor subfamily 6 group A member 1
    Names
    germ cell nuclear factor
    mGCNF
    retinoid receptor-related testis-specific receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159548.1NP_001153020.1  nuclear receptor subfamily 6 group A member 1 isoform 2

      See identical proteins and their annotated locations for NP_001153020.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AL844842, CK638822, CN532747, CN537407
      Consensus CDS
      CCDS50581.1
      UniProtKB/Swiss-Prot
      Q64249
      Related
      ENSMUSP00000126009.2, ENSMUST00000168098.8
      Conserved Domains (2) summary
      cd06953
      Location:214425
      NR_LBD_DHR4_like; The ligand binding domain of orphan nuclear receptor Ecdysone-induced receptor DHR4
      cd07169
      Location:1099
      NR_DBD_GCNF_like; DNA-binding domain of Germ cell nuclear factor (GCNF) F1 is composed of two C4-type zinc fingers
    2. NM_001159549.1NP_001153021.1  nuclear receptor subfamily 6 group A member 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AL844842, CK638822, CN532747, CN537360, CN537407
      Conserved Domains (2) summary
      cd06953
      Location:213424
      NR_LBD_DHR4_like; The ligand binding domain of orphan nuclear receptor Ecdysone-induced receptor DHR4
      cd07169
      Location:1099
      NR_DBD_GCNF_like; DNA-binding domain of Germ cell nuclear factor (GCNF) F1 is composed of two C4-type zinc fingers
    3. NM_010264.4NP_034394.1  nuclear receptor subfamily 6 group A member 1 isoform 1

      See identical proteins and their annotated locations for NP_034394.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL844842, AL935155, CK638822, CN532747, CN538225
      Consensus CDS
      CCDS16012.1
      UniProtKB/Swiss-Prot
      Q64249
      Related
      ENSMUSP00000075624.5, ENSMUST00000076275.11
      Conserved Domains (2) summary
      cd06953
      Location:271482
      NR_LBD_DHR4_like; The ligand binding domain of orphan nuclear receptor Ecdysone-induced receptor DHR4
      cd07169
      Location:67156
      NR_DBD_GCNF_like; DNA-binding domain of Germ cell nuclear factor (GCNF) F1 is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      38613381..38816473 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239025.3XP_011237327.1  nuclear receptor subfamily 6 group A member 1 isoform X1

      Conserved Domains (2) summary
      cd06953
      Location:270481
      NR_LBD_DHR4_like; The ligand binding domain of orphan nuclear receptor Ecdysone-induced receptor DHR4
      cd07169
      Location:67156
      NR_DBD_GCNF_like; DNA-binding domain of Germ cell nuclear factor (GCNF) F1 is composed of two C4-type zinc fingers
    2. XM_036158420.1XP_036014313.1  nuclear receptor subfamily 6 group A member 1 isoform X3

      Conserved Domains (2) summary
      cd06953
      Location:153364
      NR_LBD_DHR4_like; The ligand binding domain of orphan nuclear receptor Ecdysone-induced receptor DHR4
      cl02596
      Location:138
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
    3. XM_036158418.1XP_036014311.1  nuclear receptor subfamily 6 group A member 1 isoform X2

      Conserved Domains (2) summary
      cd07169
      Location:67156
      NR_DBD_GCNF_like; DNA-binding domain of Germ cell nuclear factor (GCNF) F1 is composed of two C4-type zinc fingers
      cl11397
      Location:271377
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
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