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    Eps15 epidermal growth factor receptor pathway substrate 15 [ Mus musculus (house mouse) ]

    Gene ID: 13858, updated on 4-Nov-2018

    Summary

    Official Symbol
    Eps15provided by MGI
    Official Full Name
    epidermal growth factor receptor pathway substrate 15provided by MGI
    Primary source
    MGI:MGI:104583
    See related
    Ensembl:ENSMUSG00000028552 Vega:OTTMUSG00000008289
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2410112D09Rik
    Expression
    Broad expression in cortex adult (RPKM 26.3), cerebellum adult (RPKM 24.7) and 21 other tissues See more
    Orthologs

    Genomic context

    See Eps15 in Genome Data Viewer
    Location:
    4; 4 C7
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (109280256..109387817)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (108952880..109060422)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein-like 9 Neighboring gene predicted gene, 46867 Neighboring gene predicted gene, 40225 Neighboring gene calreticulin 4 Neighboring gene predicted gene, 40224 Neighboring gene basic leucine zipper and W2 domains 1 pseudogene Neighboring gene Ttc39a opposite strand RNA 1 Neighboring gene tetratricopeptide repeat domain 39A Neighboring gene ring finger protein 11

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    cargo receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    Golgi to endosome transport ISO
    Inferred from Sequence Orthology
    more info
     
    clathrin coat assembly ISO
    Inferred from Sequence Orthology
    more info
     
    endocytic recycling ISO
    Inferred from Sequence Orthology
    more info
     
    endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of receptor recycling ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic neurotransmitter receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    receptor-mediated endocytosis of virus by host cell ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    vesicle-mediated transport in synapse ISO
    Inferred from Sequence Orthology
    more info
     
    viral entry into host cell ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    AP-2 adaptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    aggresome ISO
    Inferred from Sequence Orthology
    more info
     
    apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    basal plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    ciliary membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    clathrin coat of coated pit IDA
    Inferred from Direct Assay
    more info
    PubMed 
    clathrin-coated pit IDA
    Inferred from Direct Assay
    more info
    PubMed 
    clathrin-coated vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    endosome IEA
    Inferred from Electronic Annotation
    more info
     
    glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    epidermal growth factor receptor substrate 15
    Names
    epidermal growth factor pathway substrate 15
    protein AF-1p

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159964.1NP_001153436.1  epidermal growth factor receptor substrate 15 isoform B

      See identical proteins and their annotated locations for NP_001153436.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks multiple exons at the 5' end and has a distinct 5' UTR and start codon, compared to variant 1. These differences result in a protein (isoform B) with a shorter and distinct N-terminus, compared to isoform A. Isoform B localizes to early endosome membranes.
      Source sequence(s)
      AK083176, AW124983, BC048783, CF533628
      Consensus CDS
      CCDS51259.1
      UniProtKB/Swiss-Prot
      P42567
      UniProtKB/TrEMBL
      A0A0R4J0A0, Q80ZL3
      Related
      ENSMUSP00000030281.5, OTTMUSP00000008655, ENSMUST00000030281.11, OTTMUST00000018849
      Conserved Domains (2) summary
      pfam07926
      Location:89192
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
      cl19219
      Location:86159
      DUF342; Protein of unknown function (DUF342)
    2. NM_007943.3NP_031969.1  epidermal growth factor receptor substrate 15 isoform A

      See identical proteins and their annotated locations for NP_031969.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (A). Isoform A mainly localizes to clathrin-coated pits at the plasma membrane.
      Source sequence(s)
      AK083176, AW124983, BB858255, BC048783
      Consensus CDS
      CCDS18462.1
      UniProtKB/Swiss-Prot
      P42567
      UniProtKB/TrEMBL
      Q80ZL3
      Related
      ENSMUSP00000099790.3, OTTMUSP00000008654, ENSMUST00000102729.9, OTTMUST00000018848
      Conserved Domains (5) summary
      smart00027
      Location:121215
      EH; Eps15 homology domain
      cd00052
      Location:228293
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam07926
      Location:403506
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
      pfam12761
      Location:321458
      End3; Actin cytoskeleton-regulatory complex protein END3
      cl23720
      Location:396497
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      109280256..109387817
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502740.2XP_006502803.2  epidermal growth factor receptor substrate 15 isoform X3

      Conserved Domains (5) summary
      smart00027
      Location:121215
      EH; Eps15 homology domain
      cd00052
      Location:264329
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam07926
      Location:439542
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
      pfam12761
      Location:357494
      End3; Actin cytoskeleton-regulatory complex protein END3
      cl23720
      Location:432533
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    2. XM_006502738.2XP_006502801.2  epidermal growth factor receptor substrate 15 isoform X1

      UniProtKB/TrEMBL
      H3BK65
      Related
      ENSMUSP00000135270.1, OTTMUSP00000008656, ENSMUST00000175776.7, OTTMUST00000018852
      Conserved Domains (5) summary
      smart00027
      Location:121215
      EH; Eps15 homology domain
      cd00052
      Location:264329
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam07926
      Location:439542
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
      pfam12761
      Location:357494
      End3; Actin cytoskeleton-regulatory complex protein END3
      cl23720
      Location:432533
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    3. XM_017319956.1XP_017175445.1  epidermal growth factor receptor substrate 15 isoform X4

      Related
      ENSMUSP00000135034.1, OTTMUSP00000062124, ENSMUST00000176251.7, OTTMUST00000111138
    4. XM_006502739.3XP_006502802.2  epidermal growth factor receptor substrate 15 isoform X2

      Conserved Domains (5) summary
      smart00027
      Location:89183
      EH; Eps15 homology domain
      cd00052
      Location:232297
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam07926
      Location:407510
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
      pfam12761
      Location:325462
      End3; Actin cytoskeleton-regulatory complex protein END3
      cl23720
      Location:400501
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
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