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    OSCP1 organic solute carrier partner 1 [ Homo sapiens (human) ]

    Gene ID: 127700, updated on 17-Jun-2024

    Summary

    Official Symbol
    OSCP1provided by HGNC
    Official Full Name
    organic solute carrier partner 1provided by HGNC
    Primary source
    HGNC:HGNC:29971
    See related
    Ensembl:ENSG00000116885 MIM:608854; AllianceGenome:HGNC:29971
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NOR1; C1orf102
    Summary
    Enables transmembrane transporter activity. Involved in xenobiotic detoxification by transmembrane export across the plasma membrane. Located in basal plasma membrane and cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis (RPKM 27.5), thyroid (RPKM 6.0) and 13 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See OSCP1 in Genome Data Viewer
    Location:
    1p34.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (36417906..36450451, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (36280766..36313305, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (36883507..36916052, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36862654-36863366 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36863367-36864078 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36865796-36866392 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36866393-36866988 Neighboring gene uncharacterized LOC124904013 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 754 Neighboring gene LSM10, U7 small nuclear RNA associated Neighboring gene RNA, U4 small nuclear 27, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:36886839-36887338 Neighboring gene small nucleolar RNA, H/ACA box 63C Neighboring gene uncharacterized LOC107984940 Neighboring gene Sharpr-MPRA regulatory region 11440 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 669 Neighboring gene mitochondrial ribosomal protein S15 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:36929292-36930491 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36931829-36932691 Neighboring gene colony stimulating factor 3 receptor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:36946417-36947202

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC26685

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in xenobiotic detoxification by transmembrane export across the plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in basal plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    protein OSCP1
    Names
    organic solute carrier protein 1
    organic solute transport protein 1
    oxidored nitro domain containing protein
    oxidored-nitro domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330493.2NP_001317422.1  protein OSCP1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
      Source sequence(s)
      AC119675
      Consensus CDS
      CCDS81301.1
      UniProtKB/Swiss-Prot
      A6NHM5, A6NHS9, A6NIN9, Q4AEJ0, Q8N7G2, Q8TDF1, Q8WVF1
      UniProtKB/TrEMBL
      C9JF58
      Related
      ENSP00000349052.5, ENST00000356637.9
    2. NM_145047.5NP_659484.4  protein OSCP1 isoform 1

      See identical proteins and their annotated locations for NP_659484.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks an alternate in-frame exon compared to variant 3. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 3.
      Source sequence(s)
      AW136490, BC018069, DA297022
      Consensus CDS
      CCDS409.2
      UniProtKB/TrEMBL
      C9JF58
      Related
      ENSP00000235532.5, ENST00000235532.9
      Conserved Domains (1) summary
      pfam10188
      Location:18189
      Oscp1; Organic solute transport protein 1
    3. NM_206837.3NP_996668.1  protein OSCP1 isoform 2

      See identical proteins and their annotated locations for NP_996668.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon and differs in the 3' coding region and 3' UTR compared to variant 3. The resulting isoform (2) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 3.
      Source sequence(s)
      AF086535, BU854079, CN430132, DA297022
      Consensus CDS
      CCDS410.1
      UniProtKB/Swiss-Prot
      Q8WVF1
      Related
      ENSP00000346216.3, ENST00000354267.3
      Conserved Domains (1) summary
      pfam10188
      Location:18172
      Oscp1; Organic solute transport protein 1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      36417906..36450451 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005270462.2XP_005270519.1  protein OSCP1 isoform X3

      UniProtKB/TrEMBL
      H7C0S2
      Related
      ENSP00000396417.3, ENST00000445843.7
      Conserved Domains (1) summary
      pfam10188
      Location:18199
      Oscp1; Organic solute transport protein 1
    2. XM_011540681.4XP_011538983.1  protein OSCP1 isoform X2

      UniProtKB/TrEMBL
      C9JF58
      Conserved Domains (1) summary
      pfam10188
      Location:10161
      Oscp1; Organic solute transport protein 1
    3. XM_011540680.3XP_011538982.1  protein OSCP1 isoform X1

      UniProtKB/TrEMBL
      C9JF58
      Conserved Domains (1) summary
      pfam10188
      Location:17171
      Oscp1; Organic solute transport protein 1
    4. XM_047445746.1XP_047301702.1  protein OSCP1 isoform X6

    5. XM_047445744.1XP_047301700.1  protein OSCP1 isoform X5

    6. XM_005270463.4XP_005270520.1  protein OSCP1 isoform X4

      Conserved Domains (1) summary
      pfam10188
      Location:18182
      Oscp1; Organic solute transport protein 1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      36280766..36313305 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334378.1XP_054190353.1  protein OSCP1 isoform X3

      UniProtKB/TrEMBL
      H7C0S2
    2. XM_054334377.1XP_054190352.1  protein OSCP1 isoform X2

      UniProtKB/TrEMBL
      C9JF58
    3. XM_054334376.1XP_054190351.1  protein OSCP1 isoform X1

      UniProtKB/TrEMBL
      C9JF58
    4. XM_054334381.1XP_054190356.1  protein OSCP1 isoform X6

    5. XM_054334380.1XP_054190355.1  protein OSCP1 isoform X5

    6. XM_054334379.1XP_054190354.1  protein OSCP1 isoform X4