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    OR1I1 olfactory receptor family 1 subfamily I member 1 [ Homo sapiens (human) ]

    Gene ID: 126370, updated on 5-Mar-2024

    Summary

    Official Symbol
    OR1I1provided by HGNC
    Official Full Name
    olfactory receptor family 1 subfamily I member 1provided by HGNC
    Primary source
    HGNC:HGNC:8207
    See related
    Ensembl:ENSG00000094661 AllianceGenome:HGNC:8207
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OR1I1P; OR1I1Q; OR19-20
    Summary
    Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
    Orthologs
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    Genomic context

    See OR1I1 in Genome Data Viewer
    Location:
    19p13.12
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (15082211..15092970)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (15207150..15217911)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (15193022..15203781)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 13248 Neighboring gene tektin like 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10264 Neighboring gene caspase 14 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:15219898-15220448 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:15222723-15223250 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:15223251-15223776 Neighboring gene synapse defective Rho GTPase homolog 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:15235337-15236102 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:15236103-15236866 Neighboring gene ilvB acetolactate synthase like Neighboring gene ILVBL antisense RNA 1

    Genomic regions, transcripts, and products

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables olfactory receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in detection of chemical stimulus involved in sensory perception of smell IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    olfactory receptor 1I1
    Names
    olfactory receptor 19-20

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004713.2NP_001004713.1  olfactory receptor 1I1

      See identical proteins and their annotated locations for NP_001004713.1

      Status: VALIDATED

      Source sequence(s)
      AC004699, AC004794
      Consensus CDS
      CCDS32937.1
      UniProtKB/Swiss-Prot
      B2RU23, O60431, Q96R92
      UniProtKB/TrEMBL
      A0A126GW67
      Related
      ENSP00000493393.1, ENST00000641398.1
      Conserved Domains (2) summary
      pfam00001
      Location:41290
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:31305
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      15082211..15092970
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      15207150..15217911
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)