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    Atp6v1e1 ATPase, H+ transporting, lysosomal V1 subunit E1 [ Mus musculus (house mouse) ]

    Gene ID: 11973, updated on 31-Jan-2019

    Summary

    Official Symbol
    Atp6v1e1provided by MGI
    Official Full Name
    ATPase, H+ transporting, lysosomal V1 subunit E1provided by MGI
    Primary source
    MGI:MGI:894326
    See related
    Ensembl:ENSMUSG00000019210
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p31; Vma4; Atp6e; Atp6e2; Atp6v1e; D6Ertd385e; 2410029D23Rik
    Expression
    Ubiquitous expression in cortex adult (RPKM 139.1), frontal lobe adult (RPKM 137.5) and 28 other tissues See more
    Orthologs

    Genomic context

    See Atp6v1e1 in Genome Data Viewer
    Location:
    6 F1; 6 57.01 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (120795244..120822685, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (120745262..120772703, complement)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene CECR2, histone acetyl-lysine reader Neighboring gene solute carrier family 25 (mitochondrial carrier), member 18 Neighboring gene ribosomal protein S27 pseudogene Neighboring gene predicted gene, 38889 Neighboring gene BCL2-like 13 (apoptosis facilitator)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    proton-exporting ATPase activity, phosphorylative mechanism IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    proton-transporting ATPase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    ATP hydrolysis coupled proton transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microvillus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion HDA PubMed 
    proton-transporting two-sector ATPase complex, catalytic domain IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    V-type proton ATPase subunit E 1
    Names
    ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E
    H(+)-ATPase E-like protein
    V-ATPase 31 kDa subunit
    V-ATPase subunit E 1
    VATPase, H+ transporting, lysosomal V1 subunit E1
    vacuolar proton pump subunit E 1
    NP_031536.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007510.3NP_031536.2  V-type proton ATPase subunit E 1

      See identical proteins and their annotated locations for NP_031536.2

      Status: VALIDATED

      Source sequence(s)
      AI844873, AK139791
      Consensus CDS
      CCDS20484.1
      UniProtKB/Swiss-Prot
      P50518
      Related
      ENSMUSP00000019354.8, ENSMUST00000019354.10
      Conserved Domains (1) summary
      pfam01991
      Location:18216
      vATP-synt_E; ATP synthase (E/31 kDa) subunit

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      120795244..120822685 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 129S1/SvImJ

    Genomic

    1. NT_039382.4 Reference GRCm38.p4 129S1/SvImJ

      Range
      418343..447399 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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