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    Derl2 Der1-like domain family, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 116891, updated on 23-Jun-2021

    Summary

    Official Symbol
    Derl2provided by MGI
    Official Full Name
    Der1-like domain family, member 2provided by MGI
    Primary source
    MGI:MGI:2151483
    See related
    Ensembl:ENSMUSG00000018442
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    F; F-; Derl; Flana; CGI-10; F-lana; CGI-101; Derlin-2
    Expression
    Ubiquitous expression in placenta adult (RPKM 9.6), liver E18 (RPKM 9.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Derl2 in Genome Data Viewer
    Location:
    11 B4; 11 43.21 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (70898266..70910667, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (71007440..71019841, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (70820947..70832765, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RPA interacting protein Neighboring gene complement component 1, q subcomponent binding protein Neighboring gene DEAH (Asp-Glu-Ala-His) box polypeptide 33 Neighboring gene predicted gene, 22297 Neighboring gene MIS12 kinetochore complex component Neighboring gene RIKEN cDNA 6330403K07 gene Neighboring gene RNA binding motif protein 7 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC11613

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables misfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signal recognition particle binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-specific protease binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Hrd1p ubiquitin ligase ERAD-L complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in integral component of endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    derlin-2
    Names
    carcinoma related
    degradation in endoplasmic reticulum protein 2
    der1-like protein 2
    derlin 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291146.1NP_001278075.1  derlin-2 isoform b

      See identical proteins and their annotated locations for NP_001278075.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5'-terminal exon, lacks part of the 5' coding region, and uses a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AK082564, AK151934, AL596136, BC037503, CB526064
      Consensus CDS
      CCDS70235.1
      UniProtKB/Swiss-Prot
      Q8BNI4
      UniProtKB/TrEMBL
      Q3U957
      Related
      ENSMUSP00000127568.2, ENSMUST00000171041.8
      Conserved Domains (1) summary
      cl21536
      Location:1129
      Rhomboid; Rhomboid family
    2. NM_001291147.1NP_001278076.1  derlin-2 isoform b

      See identical proteins and their annotated locations for NP_001278076.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in its 5' UTR and uses a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AK082564, AL596136, BC037503, BE627680, CB526064
      Consensus CDS
      CCDS70235.1
      UniProtKB/Swiss-Prot
      Q8BNI4
      UniProtKB/TrEMBL
      Q3U957
      Conserved Domains (1) summary
      cl21536
      Location:1129
      Rhomboid; Rhomboid family
    3. NM_001291148.1NP_001278077.1  derlin-2 isoform c

      See identical proteins and their annotated locations for NP_001278077.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (c) is shorter, compared to isoform a.
      Source sequence(s)
      AK082564, AL596136, BC037503, CB526064
      UniProtKB/Swiss-Prot
      Q8BNI4
      Conserved Domains (1) summary
      pfam04511
      Location:13202
      DER1; Der1-like family
    4. NM_033562.4NP_291040.1  derlin-2 isoform a

      See identical proteins and their annotated locations for NP_291040.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AK082564, AL596136, BC037503, CB526064
      Consensus CDS
      CCDS24972.1
      UniProtKB/Swiss-Prot
      Q8BNI4
      Related
      ENSMUSP00000117052.2, ENSMUST00000143850.8
      Conserved Domains (1) summary
      pfam04511
      Location:13203
      DER1; Der1-like family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      70898266..70910667 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314227.3XP_017169716.1  derlin-2 isoform X1

      Conserved Domains (1) summary
      cl21536
      Location:1359
      Rhomboid; Rhomboid family
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