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    Derl2 Der1-like domain family, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 116891, updated on 5-Aug-2018

    Summary

    Official Symbol
    Derl2provided by MGI
    Official Full Name
    Der1-like domain family, member 2provided by MGI
    Primary source
    MGI:MGI:2151483
    See related
    Ensembl:ENSMUSG00000018442 Vega:OTTMUSG00000006077
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Flana; F-lana; CGI-101; Derlin-2
    Expression
    Ubiquitous expression in placenta adult (RPKM 9.6), liver E18 (RPKM 9.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Derl2 in Genome Data Viewer
    Location:
    11 B4; 11 43.21 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (71007440..71019841, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (70820947..70832765, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene RPA interacting protein Neighboring gene complement component 1, q subcomponent binding protein Neighboring gene DEAH (Asp-Glu-Ala-His) box polypeptide 33 Neighboring gene MIS12 kinetochore complex component Neighboring gene RIKEN cDNA 6330403K07 gene Neighboring gene RNA binding motif protein 7 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC11613

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    endoplasmic reticulum unfolded protein response ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of retrograde protein transport, ER to cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    response to unfolded protein IEA
    Inferred from Electronic Annotation
    more info
     
    retrograde protein transport, ER to cytosol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    retrograde protein transport, ER to cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    suckling behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ubiquitin-dependent ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    integral component of endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    late endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with signal recognition particle ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with signal recognition particle receptor complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    derlin-2
    Names
    carcinoma related
    degradation in endoplasmic reticulum protein 2
    der1-like protein 2
    derlin 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291146.1NP_001278075.1  derlin-2 isoform b

      See identical proteins and their annotated locations for NP_001278075.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5'-terminal exon, lacks part of the 5' coding region, and uses a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AK082564, AK151934, AL596136, BC037503, CB526064
      Consensus CDS
      CCDS70235.1
      UniProtKB/Swiss-Prot
      Q8BNI4
      UniProtKB/TrEMBL
      Q3U957
      Related
      ENSMUSP00000127568.1, OTTMUSP00000062342, ENSMUST00000171041.7, OTTMUST00000111386
      Conserved Domains (1) summary
      cl21536
      Location:1128
      Rhomboid; Rhomboid family
    2. NM_001291147.1NP_001278076.1  derlin-2 isoform b

      See identical proteins and their annotated locations for NP_001278076.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in its 5' UTR and uses a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AK082564, AL596136, BC037503, BE627680, CB526064
      Consensus CDS
      CCDS70235.1
      UniProtKB/Swiss-Prot
      Q8BNI4
      UniProtKB/TrEMBL
      Q3U957
      Conserved Domains (1) summary
      cl21536
      Location:1128
      Rhomboid; Rhomboid family
    3. NM_001291148.1NP_001278077.1  derlin-2 isoform c

      See identical proteins and their annotated locations for NP_001278077.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (c) is shorter, compared to isoform a.
      Source sequence(s)
      AK082564, AL596136, BC037503, CB526064
      UniProtKB/Swiss-Prot
      Q8BNI4
      Conserved Domains (1) summary
      pfam04511
      Location:13201
      DER1; Der1-like family
    4. NM_033562.4NP_291040.1  derlin-2 isoform a

      See identical proteins and their annotated locations for NP_291040.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AK082564, AL596136, BC037503, CB526064
      Consensus CDS
      CCDS24972.1
      UniProtKB/Swiss-Prot
      Q8BNI4
      Related
      ENSMUSP00000117052.1, OTTMUSP00000006360, ENSMUST00000143850.7, OTTMUST00000013718
      Conserved Domains (1) summary
      pfam04511
      Location:13202
      DER1; Der1-like family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      71007440..71019841 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314227.1XP_017169716.1  derlin-2 isoform X1

      Conserved Domains (1) summary
      cl21536
      Location:1362
      Rhomboid; Rhomboid family

    Reference GRCm38.p4 NOD/MrkTac

    Genomic

    1. NT_187026.1 Reference GRCm38.p4 NOD/MrkTac

      Range
      1115875..1128268 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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