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    Aco1 aconitase 1 [ Mus musculus (house mouse) ]

    Gene ID: 11428, updated on 23-Jun-2021

    Summary

    Official Symbol
    Aco1provided by MGI
    Official Full Name
    aconitase 1provided by MGI
    Primary source
    MGI:MGI:87879
    See related
    Ensembl:ENSMUSG00000028405
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    I; Ir; Aco; Irp1; Aco-1; Irebp
    Summary
    This gene encodes a member of the aconitase/IPM isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Depending on iron levels in the cytosol, the encoded protein can function as either an aconitase enzyme or as an mRNA binding protein. When cellular iron levels are high, the encoded protein functions as an aconitase, an essential enzyme in the TCA cycle that catalyzes the conversion of citrate to isocitrate. When cellular iron levels are low, the encoded protein regulates iron uptake and utilization by binding to iron-responsive elements in the untranslated regions of mRNAs for genes involved in iron metabolism. Disruption of this gene is associated with pulmonary hypertension and polycythemia. [provided by RefSeq, Jan 2014]
    Expression
    Ubiquitous expression in kidney adult (RPKM 60.7), genital fat pad adult (RPKM 48.3) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Aco1 in Genome Data Viewer
    Location:
    4 A5; 4 20.24 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (40143265..40199009)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (40143265..40199009)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (40090298..40146042)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 20, member 1 pseudogene Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 pseudogene Neighboring gene DEAD/H box helicase 58 Neighboring gene topoisomerase I binding, arginine/serine-rich Neighboring gene small integral membrane protein 27

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (5) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3 iron, 4 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables 3 iron, 4 sulfur cluster binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables 4 iron, 4 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables 4 iron, 4 sulfur cluster binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables aconitate hydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables aconitate hydratase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables aconitate hydratase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables citrate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables iron-responsive element binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables iron-responsive element binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables iron-responsive element binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables iron-sulfur cluster binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables mRNA 5'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cytoplasmic aconitate hydratase
    Names
    IRE-BP 1
    citrate hydro-lyase
    cytoplasmic aconitase
    iron regulatory protein 1
    iron-responsive element-binding protein 1
    NP_031412.2
    XP_036019494.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007386.2NP_031412.2  cytoplasmic aconitate hydratase

      See identical proteins and their annotated locations for NP_031412.2

      Status: VALIDATED

      Source sequence(s)
      AK163985, AL831793, BB854442, BY145469
      Consensus CDS
      CCDS18042.1
      UniProtKB/Swiss-Prot
      P28271
      Related
      ENSMUSP00000100038.4, ENSMUST00000102973.4
      Conserved Domains (1) summary
      PTZ00092
      Location:3889
      PTZ00092; aconitate hydratase-like protein; Provisional

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      40143265..40199009
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163601.1XP_036019494.1  cytoplasmic aconitate hydratase isoform X1

      Conserved Domains (1) summary
      PTZ00092
      Location:3889
      PTZ00092; aconitate hydratase-like protein; Provisional
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