Format

Send to:

Choose Destination
    • Showing Current items.

    Aco1 aconitase 1 [ Mus musculus (house mouse) ]

    Gene ID: 11428, updated on 31-Jan-2019

    Summary

    Official Symbol
    Aco1provided by MGI
    Official Full Name
    aconitase 1provided by MGI
    Primary source
    MGI:MGI:87879
    See related
    Ensembl:ENSMUSG00000028405
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Irp1; Aco-1; Irebp
    Summary
    This gene encodes a member of the aconitase/IPM isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Depending on iron levels in the cytosol, the encoded protein can function as either an aconitase enzyme or as an mRNA binding protein. When cellular iron levels are high, the encoded protein functions as an aconitase, an essential enzyme in the TCA cycle that catalyzes the conversion of citrate to isocitrate. When cellular iron levels are low, the encoded protein regulates iron uptake and utilization by binding to iron-responsive elements in the untranslated regions of mRNAs for genes involved in iron metabolism. Disruption of this gene is associated with pulmonary hypertension and polycythemia. [provided by RefSeq, Jan 2014]
    Expression
    Ubiquitous expression in kidney adult (RPKM 60.7), genital fat pad adult (RPKM 48.3) and 27 other tissues See more
    Orthologs

    Genomic context

    See Aco1 in Genome Data Viewer
    Location:
    4 A5; 4 20.24 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (40143265..40199009)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (40090298..40146042)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 34132 Neighboring gene solute carrier family 20, member 1 pseudogene Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 Neighboring gene topoisomerase I binding, arginine/serine-rich Neighboring gene small integral membrane protein 27

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    3 iron, 4 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    3 iron, 4 sulfur cluster binding ISO
    Inferred from Sequence Orthology
    more info
     
    4 iron, 4 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    4 iron, 4 sulfur cluster binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    aconitate hydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    aconitate hydratase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    aconitate hydratase activity ISO
    Inferred from Sequence Orthology
    more info
     
    iron-responsive element binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    iron-responsive element binding ISO
    Inferred from Sequence Orthology
    more info
     
    iron-sulfur cluster binding ISO
    Inferred from Sequence Orthology
    more info
     
    lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA 5'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cellular iron ion homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cellular iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular iron ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    citrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    citrate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    intestinal absorption IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    post-embryonic development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to iron(II) ion ISO
    Inferred from Sequence Orthology
    more info
     
    tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion HDA PubMed 
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cytoplasmic aconitate hydratase
    Names
    IRE-BP 1
    citrate hydro-lyase
    cytoplasmic aconitase
    iron regulatory protein 1
    iron-responsive element-binding protein 1
    NP_031412.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007386.2NP_031412.2  cytoplasmic aconitate hydratase

      See identical proteins and their annotated locations for NP_031412.2

      Status: VALIDATED

      Source sequence(s)
      AK163985, AL831793, BB854442, BY145469
      Consensus CDS
      CCDS18042.1
      UniProtKB/Swiss-Prot
      P28271
      Related
      ENSMUSP00000100038.3, ENSMUST00000102973.3
      Conserved Domains (3) summary
      cd01586
      Location:82566
      AcnA_IRP; Aconitase A catalytic domain
      cd01580
      Location:670837
      AcnA_IRP_Swivel; Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group ...
      PTZ00092
      Location:3889
      PTZ00092; aconitate hydratase-like protein; Provisional

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      40143265..40199009
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center