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    TREH trehalase [ Homo sapiens (human) ]

    Gene ID: 11181, updated on 5-Mar-2024

    Summary

    Official Symbol
    TREHprovided by HGNC
    Official Full Name
    trehalaseprovided by HGNC
    Primary source
    HGNC:HGNC:12266
    See related
    Ensembl:ENSG00000118094 MIM:275360; AllianceGenome:HGNC:12266
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TRE; TREA; TREHD
    Summary
    This gene encodes an enzyme that hydrolyses trehalose, a disaccharide formed from two glucose molecules found mainly in fungi, plants, and insects. A partial duplication of this gene is located adjacent to this locus on chromosome 11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
    Expression
    Biased expression in duodenum (RPKM 44.4), small intestine (RPKM 43.7) and 1 other tissue See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TREH in Genome Data Viewer
    Location:
    11q23.3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (118657316..118679650, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (118676537..118698868, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (118528026..118550359, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene archain 1 Neighboring gene uncharacterized LOC124902765 Neighboring gene CRISPRi-validated cis-regulatory element chr11.5498 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3948 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3949 Neighboring gene Sharpr-MPRA regulatory region 10010 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:118479501-118480175 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:118480176-118480849 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3950 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:118486166-118486683 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:118486684-118487200 Neighboring gene pleckstrin homology like domain family B member 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:118488753-118489268 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3951 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:118501544-118502052 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:118502053-118502560 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:118505587-118506258 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:118514693-118515192 Neighboring gene microRNA 6716 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:118529141-118529690 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:118529691-118530240 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:118549589-118550250 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:118550251-118550910 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:118558272-118558787 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:118558788-118559302 Neighboring gene uncharacterized LOC105369519 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5596 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5597 Neighboring gene trehalase pseudogene 1 Neighboring gene RNA, U6 small nuclear 376, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    alpha, alpha-Trehalase deficiency
    MedGen: C0268187 OMIM: 612119 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Association analyses identify three susceptibility Loci for vitiligo in the Chinese Han population.
    EBI GWAS Catalog
    Genetic determinants influencing human serum metabolome among African Americans.
    EBI GWAS Catalog
    Hundreds of variants clustered in genomic loci and biological pathways affect human height.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC129621

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables alpha,alpha-trehalase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables alpha,alpha-trehalase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in animal organ morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in trehalose catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in trehalose catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in trehalose metabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    trehalase
    Names
    alpha,alpha-trehalose glucohydrolase
    trehalase (brush-border membrane glycoprotein)
    NP_001287994.1
    NP_009111.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023321.2 RefSeqGene

      Range
      5000..27334
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001301065.2NP_001287994.1  trehalase isoform 2 precursor

      See identical proteins and their annotated locations for NP_001287994.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK223140, AP000941, BC109206
      Consensus CDS
      CCDS73401.1
      UniProtKB/Swiss-Prot
      O43280
      Related
      ENSP00000381020.2, ENST00000397925.2
      Conserved Domains (1) summary
      pfam01204
      Location:46519
      Trehalase; Trehalase
    2. NM_007180.3NP_009111.2  trehalase isoform 1 precursor

      See identical proteins and their annotated locations for NP_009111.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK223140, AK223143, AP000941
      Consensus CDS
      CCDS73402.1
      UniProtKB/Swiss-Prot
      O43280, Q32MB9, Q53FY8
      Related
      ENSP00000264029.5, ENST00000264029.9
      Conserved Domains (2) summary
      COG1626
      Location:22552
      TreA; Neutral trehalase [Carbohydrate transport and metabolism]
      pfam01204
      Location:46550
      Trehalase; Trehalase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      118657316..118679650 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      118676537..118698868 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)