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    Rap1a RAS-related protein 1a [ Mus musculus (house mouse) ]

    Gene ID: 109905, updated on 28-Aug-2018

    Summary

    Official Symbol
    Rap1aprovided by MGI
    Official Full Name
    RAS-related protein 1aprovided by MGI
    Primary source
    MGI:MGI:97852
    See related
    Ensembl:ENSMUSG00000068798 Vega:OTTMUSG00000053159
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rap1; G-22K; Krev-1; AI848598
    Expression
    Broad expression in bladder adult (RPKM 24.1), liver E14 (RPKM 21.9) and 21 other tissues See more
    Orthologs

    Genomic context

    See Rap1a in Genome Data Viewer
    Location:
    3 F2.2; 3 46.45 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (105727260..105801381, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (105531200..105604254, complement)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 20 Neighboring gene inka box actin regulator 2 Neighboring gene predicted gene 5547 Neighboring gene predicted gene, 46838

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC102329

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Rap guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Ras GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    Rap protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to cAMP ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to drug ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to nerve growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
     
    establishment of endothelial barrier ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of collagen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of synaptic vesicle exocytosis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    nerve growth factor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of ERK1 and ERK2 cascade IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glucose import ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron projection development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of vasculogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell junction assembly ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of neurotransmitter receptor localization to postsynaptic specialization membrane ISO
    Inferred from Sequence Orthology
    more info
     
    response to antineoplastic agent ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    small GTPase mediated signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    endosome IEA
    Inferred from Electronic Annotation
    more info
     
    glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    guanyl-nucleotide exchange factor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    late endosome ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    myelin sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    phagocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ras-related protein Rap-1A
    Names
    GTP-binding protein SMG-P21A
    ras-related protein Krev-1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145541.5NP_663516.1  ras-related protein Rap-1A precursor

      See identical proteins and their annotated locations for NP_663516.1

      Status: VALIDATED

      Source sequence(s)
      AA210264, AC139316, AK030897, AK152504, CX206795
      Consensus CDS
      CCDS17711.1
      UniProtKB/Swiss-Prot
      P62835
      UniProtKB/TrEMBL
      Q3U7U8, Q3V3W9
      Related
      ENSMUSP00000088174.6, OTTMUSP00000070776, ENSMUST00000090678.10, OTTMUST00000132872
      Conserved Domains (1) summary
      cd04175
      Location:3167
      Rap1; Rap1 family GTPase consists of Rap1a and Rap1b isoforms

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      105727260..105801381 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500907.3XP_006500970.1  ras-related protein Rap-1A isoform X1

      See identical proteins and their annotated locations for XP_006500970.1

      UniProtKB/Swiss-Prot
      P62835
      Conserved Domains (1) summary
      cd04175
      Location:3167
      Rap1; Rap1 family GTPase consists of Rap1a and Rap1b isoforms

    RNA

    1. XR_001783642.1 RNA Sequence

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