Rap1a RAS-related protein 1a [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rap1aprovided by MGI
Official Full Name: RAS-related protein 1aprovided by MGI
Primary source: MGI:MGI:97852
See related: Ensembl:ENSMUSG00000068798 AllianceGenome:MGI:97852
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rap1; G-22K; Krev-1
Summary: Enables GTPase activity and small GTPase binding activity. Involved in positive regulation of vasculogenesis. Acts upstream of or within several processes, including negative regulation of synaptic vesicle exocytosis; positive regulation of ERK1 and ERK2 cascade; and small GTPase-mediated signal transduction. Located in several cellular components, including cell junction; neuron projection; and sperm midpiece. Part of guanyl-nucleotide exchange factor complex. Is expressed in brain; early conceptus; eye; hemolymphoid system gland; and oocyte. Orthologous to human RAP1A (RAP1A, member of RAS oncogene family). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in bladder adult (RPKM 24.1), liver E14 (RPKM 21.9) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F2.2; 3 46.45 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (105634576..105708740, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (105727260..105801394, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

pH-sensing GPR68 inhibits vascular smooth muscle cell proliferation through Rap1A.
Title: pH-sensing GPR68 inhibits vascular smooth muscle cell proliferation through Rap1A.
Rap1A Modulates Store-Operated Calcium Entry in the Lung Endothelium: A Novel Mechanism Controlling NFAT-Mediated Vascular Inflammation and Permeability.
Title: Rap1A Modulates Store-Operated Calcium Entry in the Lung Endothelium: A Novel Mechanism Controlling NFAT-Mediated Vascular Inflammation and Permeability.
Proteomic Analysis of Rap1A GTPase Signaling-Deficient C57BL/6 Mouse Pancreas and Functional Studies Identify an Essential Role of Rap1A in Pancreas Physiology.
Title: Proteomic Analysis of Rap1A GTPase Signaling-Deficient C57BL/6 Mouse Pancreas and Functional Studies Identify an Essential Role of Rap1A in Pancreas Physiology.
Rap1 small GTPase is essential for maintaining pulmonary endothelial barrier function in mice.
Title: Rap1 small GTPase is essential for maintaining pulmonary endothelial barrier function in mice.
Distinct bidirectional regulation of LFA1 and alpha4beta7 by Rap1 and integrin adaptors in T cells under shear flow.
Title: Distinct bidirectional regulation of LFA1 and α4β7 by Rap1 and integrin adaptors in T cells under shear flow.
Rap1 regulates lumen continuity via Afadin in renal epithelia.
Title: Rap1 regulates lumen continuity via Afadin in renal epithelia.
Rap1A accelerates homocysteine-induced ANA-1 cells inflammation via synergy of FoxO1 and DNMT3a.
Title: Rap1A accelerates homocysteine-induced ANA-1 cells inflammation via synergy of FoxO1 and DNMT3a.
MiR-1224-5p modulates osteogenesis by coordinating osteoblast/osteoclast differentiation via the Rap1 signaling target ADCY2.
Title: MiR-1224-5p modulates osteogenesis by coordinating osteoblast/osteoclast differentiation via the Rap1 signaling target ADCY2.
Rap1a Activity Elevated the Impact of Endogenous AGEs in Diabetic Collagen to Stimulate Increased Myofibroblast Transition and Oxidative Stress.
Title: Rap1a Activity Elevated the Impact of Endogenous AGEs in Diabetic Collagen to Stimulate Increased Myofibroblast Transition and Oxidative Stress.
Rap1 prevents colitogenic Th17 cell expansion and facilitates Treg cell differentiation and distal TCR signaling.
Title: Rap1 prevents colitogenic Th17 cell expansion and facilitates Treg cell differentiation and distal TCR signaling.

Submit: New GeneRIF Correction See all GeneRIFs (87)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Rap1a (e-PCR), detects polymorphism
- UniSTS:532892

AI848598 (e-PCR)
- UniSTS:185558

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein activity	IEA Inferred from Electronic Annotation more info
enables GDP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info	PubMed
enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Rap protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in Rap protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in Rap protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to cAMP	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to cAMP	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cAMP	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to nerve growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to nerve growth factor stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
involved_in cellular response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in establishment of endothelial barrier	ISO Inferred from Sequence Orthology more info
involved_in establishment of endothelial barrier	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of collagen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of synaptic vesicle exocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of synaptic vesicle exocytosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nerve growth factor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in nerve growth factor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of D-glucose import	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of Fc receptor mediated stimulatory signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of vasculogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell junction assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell junction assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IEA Inferred from Electronic Annotation more info
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info
involved_in response to antineoplastic agent	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within small GTPase-mediated signal transduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of synaptic vesicle exocytosis	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
part_of guanyl-nucleotide exchange factor complex	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in late endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in myelin sheath	HDA more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in phagocytic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	IEA Inferred from Electronic Annotation more info
located_in sperm midpiece	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ras-related protein Rap-1A

Names: GTP-binding protein SMG-P21A; ras-related protein Krev-1

NP_663516.1

EC 3.6.5.2

XP_006500970.1

EC 3.6.5.2

XP_030108244.1

EC 3.6.5.2

XP_030108245.1

EC 3.6.5.2

XP_030108246.1

EC 3.6.5.2

XP_036018749.1

EC 3.6.5.2

XP_036018750.1

EC 3.6.5.2

XP_036018751.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145541.5 → NP_663516.1 ras-related protein Rap-1A

See identical proteins and their annotated locations for NP_663516.1

Status: VALIDATED

Source sequence(s)

AA210264, AC139316, AK030897, AK152504, CX206795

Consensus CDS

CCDS17711.1

UniProtKB/Swiss-Prot

P62835

UniProtKB/TrEMBL

Q3V3W9

Related

ENSMUSP00000088174.7, ENSMUST00000090678.11

Conserved Domains (1) summary

cd04175
Location:3 → 167

Rap1; Rap1 family GTPase consists of Rap1a and Rap1b isoforms

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

105634576..105708740 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006500907.5 → XP_006500970.1 ras-related protein Rap-1A isoform X1

See identical proteins and their annotated locations for XP_006500970.1

UniProtKB/Swiss-Prot

P62835

UniProtKB/TrEMBL

Q3V3W9

Conserved Domains (1) summary

cd04175
Location:3 → 167

Rap1; Rap1 family GTPase consists of Rap1a and Rap1b isoforms
XM_036162856.1 → XP_036018749.1 ras-related protein Rap-1A isoform X1

UniProtKB/Swiss-Prot

P62835

UniProtKB/TrEMBL

Q3V3W9

Conserved Domains (1) summary

cd04175
Location:3 → 167

Rap1; Rap1 family GTPase consists of Rap1a and Rap1b isoforms
XM_036162858.1 → XP_036018751.1 ras-related protein Rap-1A isoform X1

UniProtKB/Swiss-Prot

P62835

UniProtKB/TrEMBL

Q3V3W9

Conserved Domains (1) summary

cd04175
Location:3 → 167

Rap1; Rap1 family GTPase consists of Rap1a and Rap1b isoforms
XM_030252384.2 → XP_030108244.1 ras-related protein Rap-1A isoform X1

UniProtKB/Swiss-Prot

P62835

UniProtKB/TrEMBL

Q3V3W9

Conserved Domains (1) summary

cd04175
Location:3 → 167

Rap1; Rap1 family GTPase consists of Rap1a and Rap1b isoforms
XM_030252385.2 → XP_030108245.1 ras-related protein Rap-1A isoform X1

UniProtKB/Swiss-Prot

P62835

UniProtKB/TrEMBL

Q3V3W9

Related

ENSMUSP00000142634.2, ENSMUST00000199969.5

Conserved Domains (1) summary

cd04175
Location:3 → 167

Rap1; Rap1 family GTPase consists of Rap1a and Rap1b isoforms
XM_036162857.1 → XP_036018750.1 ras-related protein Rap-1A isoform X1

UniProtKB/Swiss-Prot

P62835

UniProtKB/TrEMBL

Q3V3W9

Conserved Domains (1) summary

cd04175
Location:3 → 167

Rap1; Rap1 family GTPase consists of Rap1a and Rap1b isoforms
XM_030252386.2 → XP_030108246.1 ras-related protein Rap-1A isoform X1

UniProtKB/Swiss-Prot

P62835

UniProtKB/TrEMBL

Q3V3W9

Conserved Domains (1) summary

cd04175
Location:3 → 167

Rap1; Rap1 family GTPase consists of Rap1a and Rap1b isoforms