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    Prr5 proline rich 5 (renal) [ Mus musculus (house mouse) ]

    Gene ID: 109270, updated on 23-May-2018

    Summary

    Official Symbol
    Prr5provided by MGI
    Official Full Name
    proline rich 5 (renal)provided by MGI
    Primary source
    MGI:MGI:1924714
    See related
    Ensembl:ENSMUSG00000036106 Vega:OTTMUSG00000035390
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C78947; Arhgap8; Protor1; AU043908; Protor-1; C030017C09Rik
    Expression
    Broad expression in genital fat pad adult (RPKM 17.2), duodenum adult (RPKM 16.7) and 28 other tissues See more
    Orthologs

    Genomic context

    See Prr5 in Genome Data Viewer
    Location:
    15; 15 E2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (84663171..84706409)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (84511428..84534103)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 34095 Neighboring gene predicted gene, 34201 Neighboring gene predicted gene, 41374 Neighboring gene predicted gene, 20556 Neighboring gene Rho GTPase activating protein 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Clone Names

    • MGC32512

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    TORC2 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of phosphatidylinositol 3-kinase signaling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of phosphatidylinositol 3-kinase signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    TORC2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    TORC2 complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    proline-rich protein 5
    Names
    protein observed with Rictor-1
    prr5

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001346662.1NP_001333591.1  proline-rich protein 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK046057, AL611986, AL611987
      Consensus CDS
      CCDS84185.1
      UniProtKB/Swiss-Prot
      Q812A5
    2. NM_146061.4NP_666173.4  proline-rich protein 5 isoform 1

      See identical proteins and their annotated locations for NP_666173.4

      Status: VALIDATED

      Source sequence(s)
      AK028831, AK081231, AV002324, BE653785, BF458163, BG079574, BY059925, W99003
      Consensus CDS
      CCDS27711.1
      UniProtKB/Swiss-Prot
      Q812A5
      Related
      ENSMUSP00000066396.4, OTTMUSP00000049667, ENSMUST00000065499.4, OTTMUST00000090495
      Conserved Domains (1) summary
      pfam08539
      Location:40159
      HbrB; HbrB-like

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      84663171..84706409
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520278.2XP_006520341.2  proline-rich protein 5 isoform X1

      Conserved Domains (1) summary
      pfam08539
      Location:31150
      HbrB; HbrB-like
    2. XM_006520279.2XP_006520342.2  proline-rich protein 5 isoform X2

      Conserved Domains (1) summary
      pfam08539
      Location:163
      HbrB; HbrB-like
    3. XM_006520281.3XP_006520344.1  proline-rich protein 5 isoform X1

      See identical proteins and their annotated locations for XP_006520344.1

      UniProtKB/Swiss-Prot
      Q812A5
      Related
      ENSMUSP00000127890.1, OTTMUSP00000049666, ENSMUST00000171460.7, OTTMUST00000090494
      Conserved Domains (1) summary
      pfam08539
      Location:31150
      HbrB; HbrB-like
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