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    CGA glycoprotein hormones, alpha polypeptide [ Homo sapiens (human) ]

    Gene ID: 1081, updated on 5-Mar-2024

    Summary

    Official Symbol
    CGAprovided by HGNC
    Official Full Name
    glycoprotein hormones, alpha polypeptideprovided by HGNC
    Primary source
    HGNC:HGNC:1885
    See related
    Ensembl:ENSG00000135346 MIM:118850; AllianceGenome:HGNC:1885
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HCG; LHA; FSHA; GPA1; GPHa; TSHA; GPHA1; CG-ALPHA
    Summary
    The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
    Expression
    Restricted expression toward placenta (RPKM 388.3) See more
    Orthologs
    NEW
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    Genomic context

    See CGA in Genome Data Viewer
    Location:
    6q14.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (87085498..87095106, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (88294252..88303837, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (87795216..87804824, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene small integral membrane protein 30-like Neighboring gene RN7SK pseudogene 209 Neighboring gene reticulocalbin 1 pseudogene 1 Neighboring gene translation initiation factor IF-2-like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24792 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:87861807-87862307 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24793

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables follicle-stimulating hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables follicle-stimulating hormone activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables hormone activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in follicle-stimulating hormone secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in follicle-stimulating hormone signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in hormone-mediated signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in luteinizing hormone secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of organ growth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in organ growth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell migration NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of steroid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of steroid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in thyroid gland development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in thyroid hormone generation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in Golgi lumen TAS
    Traceable Author Statement
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of follicle-stimulating hormone complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of follicle-stimulating hormone complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of follicle-stimulating hormone complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of pituitary gonadotropin complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of pituitary gonadotropin complex NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    glycoprotein hormones alpha chain
    Names
    FSH-alpha
    LSH-alpha
    TSH-alpha
    anterior pituitary glycoprotein hormones common subunit alpha
    choriogonadotropin alpha chain
    chorionic gonadotrophin subunit alpha
    chorionic gonadotropin, alpha polypeptide
    follicle-stimulating hormone alpha chain
    follicle-stimulating hormone alpha subunit
    follitropin alpha chain
    luteinizing hormone alpha chain
    lutropin alpha chain
    thyroid-stimulating hormone alpha chain
    thyrotropin alpha chain

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000735.4NP_000726.1  glycoprotein hormones alpha chain isoform 2 precursor

      See identical proteins and their annotated locations for NP_000726.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AI200485, BC055080, BG619154
      Consensus CDS
      CCDS5007.1
      UniProtKB/Swiss-Prot
      P01215
      UniProtKB/TrEMBL
      Q6I9S8, Q96QJ4
      Related
      ENSP00000486024.1, ENST00000627148.3
      Conserved Domains (1) summary
      pfam00236
      Location:28116
      Hormone_6; Glycoprotein hormone
    2. NM_001252383.2NP_001239312.1  glycoprotein hormones alpha chain isoform 1 precursor

      See identical proteins and their annotated locations for NP_001239312.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AI200485, BC055080, BG571584, BG619154
      Consensus CDS
      CCDS75492.1
      UniProtKB/TrEMBL
      A0A087WYZ4
      Related
      ENSP00000482232.1, ENST00000610310.3
      Conserved Domains (1) summary
      pfam00236
      Location:60140
      Hormone_6; Glycoprotein hormone

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      87085498..87095106 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      88294252..88303837 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)