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    Pdzd8 PDZ domain containing 8 [ Mus musculus (house mouse) ]

    Gene ID: 107368, updated on 8-Feb-2024


    Official Symbol
    Pdzd8provided by MGI
    Official Full Name
    PDZ domain containing 8provided by MGI
    Primary source
    See related
    Ensembl:ENSMUSG00000074746 AllianceGenome:MGI:2677270
    Gene type
    protein coding
    RefSeq status
    Mus musculus
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pdzk8; A630041P07Rik
    Predicted to enable lipid binding activity and metal ion binding activity. Involved in mitochondrial calcium ion homeostasis and mitochondrion-endoplasmic reticulum membrane tethering. Located in endoplasmic reticulum membrane and mitochondria-associated endoplasmic reticulum membrane. Is expressed in several structures, including cardiovascular system; central nervous system; genitourinary system; gut; and retina nuclear layer. Orthologous to human PDZD8 (PDZ domain containing 8). [provided by Alliance of Genome Resources, Apr 2022]
    Ubiquitous expression in testis adult (RPKM 15.4), ovary adult (RPKM 6.8) and 28 other tissues See more
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    Genomic context

    See Pdzd8 in Genome Data Viewer
    19 D3; 19 54.65 cM
    Exon count:
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (59284516..59334212, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (59296084..59345780, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene potassium channel, subfamily K, member 18 Neighboring gene VISTA enhancer mm447 Neighboring gene solute carrier family 18 (vesicular monoamine), member 2 Neighboring gene ribosomal protein S12, pseudogene 3 Neighboring gene predicted gene, 50440 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:59463713-59463963 Neighboring gene predicted gene, 33756 Neighboring gene VISTA enhancer mm448 Neighboring gene Emx2 opposite strand/antisense transcript, non-protein coding

    Genomic regions, transcripts, and products


    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a


    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?



    Alleles of this type are documented at Mouse Genome Informatics  (MGI)


    Products Interactant Other Gene Complex Source Pubs Description

    General gene information


    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    enables molecular_function ND
    No biological Data available
    more info
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    is_active_in mitochondria-associated endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    located_in mitochondria-associated endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    located_in mitochondria-associated endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info

    General protein information

    Preferred Names
    PDZ domain-containing protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033222.3NP_001028394.2  PDZ domain-containing protein 8

      See identical proteins and their annotated locations for NP_001028394.2

      Status: VALIDATED

      Source sequence(s)
      AC139040, AK145020
      Consensus CDS
      B9EJ80, Q3UMB1
      ENSMUSP00000096880.3, ENSMUST00000099274.4
      Conserved Domains (4) summary
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      DUF4045; Domain of unknown function (DUF4045)
      Atrophin-1; Atrophin-1 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J


    1. NC_000085.7 Reference GRCm39 C57BL/6J

      59284516..59334212 complement
      GenBank, FASTA, Sequence Viewer (Graphics)