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    Pdzd8 PDZ domain containing 8 [ Mus musculus (house mouse) ]

    Gene ID: 107368, updated on 12-Aug-2018

    Summary

    Official Symbol
    Pdzd8provided by MGI
    Official Full Name
    PDZ domain containing 8provided by MGI
    Primary source
    MGI:MGI:2677270
    See related
    Ensembl:ENSMUSG00000074746
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pdzk8; AV329468; AW228944; A630041P07Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 15.4), ovary adult (RPKM 6.8) and 28 other tissues See more
    Orthologs

    Genomic context

    See Pdzd8 in Genome Data Viewer
    Location:
    19; 19 D3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (59296084..59345780, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (59370574..59420270, complement)

    Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene potassium channel, subfamily K, member 18 Neighboring gene solute carrier family 18 (vesicular monoamine), member 2 Neighboring gene ribosomal protein S12, pseudogene 3 Neighboring gene predicted gene, 33756 Neighboring gene Emx2 opposite strand/antisense transcript (non-protein coding)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    lipid transport IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial calcium ion homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion-endoplasmic reticulum membrane tethering IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion-endoplasmic reticulum membrane tethering ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Mitochondria-associated ER Membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Mitochondria-associated ER Membrane ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    PDZ domain-containing protein 8

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033222.3NP_001028394.2  PDZ domain-containing protein 8

      See identical proteins and their annotated locations for NP_001028394.2

      Status: VALIDATED

      Source sequence(s)
      AC139040, AK145020
      Consensus CDS
      CCDS29936.1
      UniProtKB/Swiss-Prot
      B9EJ80
      Related
      ENSMUSP00000096880.2, ENSMUST00000099274.2
      Conserved Domains (4) summary
      cd00029
      Location:834876
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00992
      Location:363440
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl25751
      Location:552696
      DUF4045; Domain of unknown function (DUF4045)
      cl26464
      Location:445631
      Atrophin-1; Atrophin-1 family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

      Range
      59296084..59345780 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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