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    Dhx57 DExH-box helicase 57 [ Mus musculus (house mouse) ]

    Gene ID: 106794, updated on 8-Feb-2024

    Summary

    Official Symbol
    Dhx57provided by MGI
    Official Full Name
    DExH-box helicase 57provided by MGI
    Primary source
    MGI:MGI:2147067
    See related
    Ensembl:ENSMUSG00000035051 AllianceGenome:MGI:2147067
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable RNA binding activity. Is expressed in central nervous system and retina. Orthologous to human DHX57 (DExH-box helicase 57). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E18 (RPKM 21.0), CNS E14 (RPKM 17.1) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Dhx57 in Genome Data Viewer
    Location:
    17 E3; 17 50.63 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (80545733..80597620, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (80238304..80290476, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3216 Neighboring gene STARR-positive B cell enhancer ABC_E7559 Neighboring gene serine and arginine-rich splicing factor 7 Neighboring gene STARR-positive B cell enhancer ABC_E5631 Neighboring gene gem nuclear organelle associated protein 6 Neighboring gene tetratricopeptide repeat domain 39D Neighboring gene STARR-positive B cell enhancer ABC_E3217 Neighboring gene STARR-positive B cell enhancer ABC_E5632 Neighboring gene STARR-seq mESC enhancer starr_43307 Neighboring gene STARR-seq mESC enhancer starr_43308 Neighboring gene STARR-positive B cell enhancer ABC_E7560 Neighboring gene MORN repeat containing 2 Neighboring gene Rho guanine nucleotide exchange factor 33 Neighboring gene STARR-seq mESC enhancer starr_43309 Neighboring gene STARR-seq mESC enhancer starr_43310 Neighboring gene predicted gene 10190

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC77974

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in intracellular anatomical structure IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    putative ATP-dependent RNA helicase DHX57
    Names
    DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 homolog
    DEAH box protein 57
    NP_001157231.1
    NP_001397255.1
    NP_001397256.1
    NP_001397257.1
    NP_945180.2
    XP_030105293.1
    XP_030105294.1
    XP_030105295.1
    XP_030105296.1
    XP_030105297.1
    XP_036016147.1
    XP_036016148.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163759.2NP_001157231.1  putative ATP-dependent RNA helicase DHX57 isoform 1

      See identical proteins and their annotated locations for NP_001157231.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC132910
      Consensus CDS
      CCDS50188.1
      UniProtKB/Swiss-Prot
      Q3TS93, Q6NZK4, Q6P1B4, Q6P5D3, Q8BI63, Q8BIA2, Q8R360
      Related
      ENSMUSP00000083742.4, ENSMUST00000086555.11
      Conserved Domains (3) summary
      COG1643
      Location:5011298
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      cd14317
      Location:181218
      UBA_DHX57; UBA domain found in putative ATP-dependent RNA helicase DHX57 and similar proteins
      pfam05773
      Location:246419
      RWD; RWD domain
    2. NM_001410326.1NP_001397255.1  putative ATP-dependent RNA helicase DHX57 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC132910
      UniProtKB/Swiss-Prot
      Q3TS93, Q6NZK4, Q6P1B4, Q6P5D3, Q8BI63, Q8BIA2, Q8R360
    3. NM_001410327.1NP_001397256.1  putative ATP-dependent RNA helicase DHX57 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC132910
    4. NM_001410328.1NP_001397257.1  putative ATP-dependent RNA helicase DHX57 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC132910
    5. NM_198942.3NP_945180.2  putative ATP-dependent RNA helicase DHX57 isoform 2

      See identical proteins and their annotated locations for NP_945180.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC132910
      Consensus CDS
      CCDS28990.1
      UniProtKB/Swiss-Prot
      Q6P5D3
      Related
      ENSMUSP00000041069.8, ENSMUST00000038166.9
      Conserved Domains (3) summary
      COG1643
      Location:4481245
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      cd14317
      Location:128165
      UBA_DHX57; UBA domain found in putative ATP-dependent RNA helicase DHX57 and similar proteins
      pfam05773
      Location:193366
      RWD; RWD domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      80545733..80597620 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160255.1XP_036016148.1  putative ATP-dependent RNA helicase DHX57 isoform X7

      Conserved Domains (1) summary
      COG1643
      Location:82548
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    2. XM_030249437.2XP_030105297.1  putative ATP-dependent RNA helicase DHX57 isoform X6

      Conserved Domains (1) summary
      COG1643
      Location:11771
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    3. XM_030249433.2XP_030105293.1  putative ATP-dependent RNA helicase DHX57 isoform X3

      Conserved Domains (3) summary
      COG1643
      Location:4321229
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      cd14317
      Location:112149
      UBA_DHX57; UBA domain found in putative ATP-dependent RNA helicase DHX57 and similar proteins
      pfam05773
      Location:177350
      RWD; RWD domain
    4. XM_030249436.1XP_030105296.1  putative ATP-dependent RNA helicase DHX57 isoform X4

      Conserved Domains (2) summary
      COG1643
      Location:2721069
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      pfam05773
      Location:17190
      RWD; RWD domain
    5. XM_030249435.2XP_030105295.1  putative ATP-dependent RNA helicase DHX57 isoform X4

      Conserved Domains (2) summary
      COG1643
      Location:2721069
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      pfam05773
      Location:17190
      RWD; RWD domain
    6. XM_030249434.2XP_030105294.1  putative ATP-dependent RNA helicase DHX57 isoform X3

      Conserved Domains (3) summary
      COG1643
      Location:4321229
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      cd14317
      Location:112149
      UBA_DHX57; UBA domain found in putative ATP-dependent RNA helicase DHX57 and similar proteins
      pfam05773
      Location:177350
      RWD; RWD domain
    7. XM_036160254.1XP_036016147.1  putative ATP-dependent RNA helicase DHX57 isoform X5

      Related
      ENSMUST00000234733.2
      Conserved Domains (4) summary
      COG1643
      Location:5011008
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      cd14317
      Location:181218
      UBA_DHX57; UBA domain found in putative ATP-dependent RNA helicase DHX57 and similar proteins
      pfam05773
      Location:246419
      RWD; RWD domain
      pfam18345
      Location:305323
      zf_CCCH_4; Zinc finger domain

    RNA

    1. XR_003952074.2 RNA Sequence