Format

Send to:

Choose Destination
    • Showing Current items.

    Dhx57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 [ Mus musculus (house mouse) ]

    Gene ID: 106794, updated on 23-Jun-2021

    Summary

    Official Symbol
    Dhx57provided by MGI
    Official Full Name
    DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57provided by MGI
    Primary source
    MGI:MGI:2147067
    See related
    Ensembl:ENSMUSG00000035051
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AW494914
    Expression
    Broad expression in CNS E18 (RPKM 21.0), CNS E14 (RPKM 17.1) and 27 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Dhx57 in Genome Data Viewer
    Location:
    17; 17 E3
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (80545733..80597905, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (80238304..80290476, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (80637644..80689816, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene serine and arginine-rich splicing factor 7 Neighboring gene gem nuclear organelle associated protein 6 Neighboring gene tetratricopeptide repeat domain 39D Neighboring gene MORN repeat containing 2 Neighboring gene Rho guanine nucleotide exchange factor (GEF) 33 Neighboring gene predicted gene 10190 Neighboring gene SOS Ras/Rac guanine nucleotide exchange factor 1 Neighboring gene ribosomal protein L17 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC77974

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in intracellular anatomical structure IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    putative ATP-dependent RNA helicase DHX57
    Names
    DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 homolog
    DEAH box protein 57
    NP_001157231.1
    NP_945180.2
    XP_006523510.1
    XP_006523511.1
    XP_030105293.1
    XP_030105294.1
    XP_030105295.1
    XP_030105296.1
    XP_030105297.1
    XP_036016147.1
    XP_036016148.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163759.1NP_001157231.1  putative ATP-dependent RNA helicase DHX57 isoform 1

      See identical proteins and their annotated locations for NP_001157231.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AW488262, BC062952, BC065169
      Consensus CDS
      CCDS50188.1
      UniProtKB/Swiss-Prot
      Q6P5D3
      Related
      ENSMUSP00000083742.4, ENSMUST00000086555.11
      Conserved Domains (3) summary
      COG1643
      Location:5011298
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      cd14317
      Location:181218
      UBA_DHX57; UBA domain found in putative ATP-dependent RNA helicase DHX57 and similar proteins
      pfam05773
      Location:246419
      RWD; RWD domain
    2. NM_198942.2NP_945180.2  putative ATP-dependent RNA helicase DHX57 isoform 2

      See identical proteins and their annotated locations for NP_945180.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AW488262, BC062952, BC065169
      Consensus CDS
      CCDS28990.1
      UniProtKB/Swiss-Prot
      Q6P5D3
      Related
      ENSMUSP00000041069.8, ENSMUST00000038166.9
      Conserved Domains (3) summary
      COG1643
      Location:4481245
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      cd14317
      Location:128165
      UBA_DHX57; UBA domain found in putative ATP-dependent RNA helicase DHX57 and similar proteins
      pfam05773
      Location:193366
      RWD; RWD domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      80545733..80597905 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523447.3XP_006523510.1  putative ATP-dependent RNA helicase DHX57 isoform X1

      See identical proteins and their annotated locations for XP_006523510.1

      UniProtKB/Swiss-Prot
      Q6P5D3
      Conserved Domains (3) summary
      COG1643
      Location:5011298
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      cd14317
      Location:181218
      UBA_DHX57; UBA domain found in putative ATP-dependent RNA helicase DHX57 and similar proteins
      pfam05773
      Location:246419
      RWD; RWD domain
    2. XM_036160255.1XP_036016148.1  putative ATP-dependent RNA helicase DHX57 isoform X7

      Conserved Domains (1) summary
      COG1643
      Location:82548
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    3. XM_030249437.2XP_030105297.1  putative ATP-dependent RNA helicase DHX57 isoform X6

      Conserved Domains (1) summary
      COG1643
      Location:11771
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    4. XM_030249433.2XP_030105293.1  putative ATP-dependent RNA helicase DHX57 isoform X3

      Conserved Domains (3) summary
      COG1643
      Location:4321229
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      cd14317
      Location:112149
      UBA_DHX57; UBA domain found in putative ATP-dependent RNA helicase DHX57 and similar proteins
      pfam05773
      Location:177350
      RWD; RWD domain
    5. XM_006523448.3XP_006523511.1  putative ATP-dependent RNA helicase DHX57 isoform X2

      See identical proteins and their annotated locations for XP_006523511.1

      UniProtKB/Swiss-Prot
      Q6P5D3
      Conserved Domains (3) summary
      COG1643
      Location:4481245
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      cd14317
      Location:128165
      UBA_DHX57; UBA domain found in putative ATP-dependent RNA helicase DHX57 and similar proteins
      pfam05773
      Location:193366
      RWD; RWD domain
    6. XM_030249436.1XP_030105296.1  putative ATP-dependent RNA helicase DHX57 isoform X4

      Conserved Domains (2) summary
      COG1643
      Location:2721069
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      pfam05773
      Location:17190
      RWD; RWD domain
    7. XM_030249435.2XP_030105295.1  putative ATP-dependent RNA helicase DHX57 isoform X4

      Conserved Domains (2) summary
      COG1643
      Location:2721069
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      pfam05773
      Location:17190
      RWD; RWD domain
    8. XM_030249434.2XP_030105294.1  putative ATP-dependent RNA helicase DHX57 isoform X3

      Conserved Domains (3) summary
      COG1643
      Location:4321229
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      cd14317
      Location:112149
      UBA_DHX57; UBA domain found in putative ATP-dependent RNA helicase DHX57 and similar proteins
      pfam05773
      Location:177350
      RWD; RWD domain
    9. XM_036160254.1XP_036016147.1  putative ATP-dependent RNA helicase DHX57 isoform X5

      Related
      ENSMUST00000234733.2
      Conserved Domains (4) summary
      COG1643
      Location:5011008
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      cd14317
      Location:181218
      UBA_DHX57; UBA domain found in putative ATP-dependent RNA helicase DHX57 and similar proteins
      pfam05773
      Location:246419
      RWD; RWD domain
      pfam18345
      Location:305323
      zf_CCCH_4; Zinc finger domain

    RNA

    1. XR_003952074.2 RNA Sequence

    Support Center